Screening of Zulu medicinal plants for angiotensin converting enzyme (ACE) inhibitors
Twenty plants used by traditional healers in South Africa for the treatment of high blood pressure were investigated for their anti-hypertensive properties, utilizing the angiotensin converting enzyme assay. A hit rate of 65% was achieved, with the highest inhibition (97%) obtained by Adenopodia spi...
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| Veröffentlicht in: | Journal of ethnopharmacology 1999-12, Vol.68 (1), p.63-70 |
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| creator | Duncan, Andrew C Jäger, Anna K van Staden, Johannes |
| description | Twenty plants used by traditional healers in South Africa for the treatment of high blood pressure were investigated for their anti-hypertensive properties, utilizing the angiotensin converting enzyme assay. A hit rate of 65% was achieved, with the highest inhibition (97%) obtained by
Adenopodia spicata leaves. A further seven plants exhibited an inhibition greater than 70% and five more over 50%. The leaves of the plants showed the greatest levels of inhibition. There was little difference in the overall hit rate between ethanolic and aqueous extracts, although in most cases there was a marked difference in activity between aqueous and ethanolic extracts from the same species. Plants exhibiting inhibition levels greater than 50% were further tested for the presence of tannins in order to eliminate possible false positives. Active plants that did not contain tannins were
Agapanthus africanus, Agave americana, Clausena anisata, Dietes iridioides, Mesembruanthemum spp.,
Stangeria eriopus and
Tulbaghia
violacea. |
| doi_str_mv | 10.1016/S0378-8741(99)00097-5 |
| format | Article |
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Adenopodia spicata leaves. A further seven plants exhibited an inhibition greater than 70% and five more over 50%. The leaves of the plants showed the greatest levels of inhibition. There was little difference in the overall hit rate between ethanolic and aqueous extracts, although in most cases there was a marked difference in activity between aqueous and ethanolic extracts from the same species. Plants exhibiting inhibition levels greater than 50% were further tested for the presence of tannins in order to eliminate possible false positives. Active plants that did not contain tannins were
Agapanthus africanus, Agave americana, Clausena anisata, Dietes iridioides, Mesembruanthemum spp.,
Stangeria eriopus and
Tulbaghia
violacea.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/S0378-8741(99)00097-5</identifier><identifier>PMID: 10624863</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Angiotensin converting enzyme ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Antihypertensive Agents - analysis ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical - methods ; False Positive Reactions ; General pharmacology ; Hypertension ; Medical sciences ; Medicinal plants ; Medicine, Traditional ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Leaves - chemistry ; Plants, Medicinal - chemistry ; Solubility ; South Africa ; Tannins - analysis ; Time Factors ; Traditional healers ; traditional medicine</subject><ispartof>Journal of ethnopharmacology, 1999-12, Vol.68 (1), p.63-70</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-4765f4bb23a9a73b83ff9b559b5a9f77310d2b433104c8c4d4971fabf2a60db53</citedby><cites>FETCH-LOGICAL-c480t-4765f4bb23a9a73b83ff9b559b5a9f77310d2b433104c8c4d4971fabf2a60db53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874199000975$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1186610$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10624863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duncan, Andrew C</creatorcontrib><creatorcontrib>Jäger, Anna K</creatorcontrib><creatorcontrib>van Staden, Johannes</creatorcontrib><title>Screening of Zulu medicinal plants for angiotensin converting enzyme (ACE) inhibitors</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Twenty plants used by traditional healers in South Africa for the treatment of high blood pressure were investigated for their anti-hypertensive properties, utilizing the angiotensin converting enzyme assay. A hit rate of 65% was achieved, with the highest inhibition (97%) obtained by
Adenopodia spicata leaves. A further seven plants exhibited an inhibition greater than 70% and five more over 50%. The leaves of the plants showed the greatest levels of inhibition. There was little difference in the overall hit rate between ethanolic and aqueous extracts, although in most cases there was a marked difference in activity between aqueous and ethanolic extracts from the same species. Plants exhibiting inhibition levels greater than 50% were further tested for the presence of tannins in order to eliminate possible false positives. Active plants that did not contain tannins were
Agapanthus africanus, Agave americana, Clausena anisata, Dietes iridioides, Mesembruanthemum spp.,
Stangeria eriopus and
Tulbaghia
violacea.</description><subject>Angiotensin converting enzyme</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Antihypertensive Agents - analysis</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>False Positive Reactions</subject><subject>General pharmacology</subject><subject>Hypertension</subject><subject>Medical sciences</subject><subject>Medicinal plants</subject><subject>Medicine, Traditional</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Leaves - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Solubility</subject><subject>South Africa</subject><subject>Tannins - analysis</subject><subject>Time Factors</subject><subject>Traditional healers</subject><subject>traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9vFCEUB3Biauy2-ieoHEzTHkZhYPhxajabtpo08bDuxQsBBlbMLGxhpkn962U7G_VmCHmXz-O9fAHgLUYfMcLs0xoRLhrBKb6U8gohJHnTvQALLHjb8I6TE7D4Q07BWSk_K-KYolfgFCPWUsHIAmzWNjsXQ9zC5OH3aZjgzvXBhqgHuB90HAv0KUMdtyGNLpYQoU3x0eXx0OPir6edg5fL1c0VDPFHMGFMubwGL70eintzrOdgc3vzbfW5uf9692W1vG8sFWhsKGedp8a0REvNiRHEe2m6rl4tPecEo741lNRKrbC0p5Jjr41vNUO96cg5uJjf3ef0MLkyql0o1g11b5emopgk9WBRYTdDm1Mp2Xm1z2Gn85PCSB3yVM95qkNYSkr1nKc6DHh3HDCZmss_XXOAFXw4Al2sHnzW0Yby12HBGEaVvZ-Z10npba5ks24RJqiVhDIkq7iehat5PQaXVbHBRVs_Izs7qj6F_-z6G8QImuY</recordid><startdate>19991215</startdate><enddate>19991215</enddate><creator>Duncan, Andrew C</creator><creator>Jäger, Anna K</creator><creator>van Staden, Johannes</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991215</creationdate><title>Screening of Zulu medicinal plants for angiotensin converting enzyme (ACE) inhibitors</title><author>Duncan, Andrew C ; Jäger, Anna K ; van Staden, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-4765f4bb23a9a73b83ff9b559b5a9f77310d2b433104c8c4d4971fabf2a60db53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Angiotensin converting enzyme</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Antihypertensive Agents - analysis</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>False Positive Reactions</topic><topic>General pharmacology</topic><topic>Hypertension</topic><topic>Medical sciences</topic><topic>Medicinal plants</topic><topic>Medicine, Traditional</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Leaves - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Solubility</topic><topic>South Africa</topic><topic>Tannins - analysis</topic><topic>Time Factors</topic><topic>Traditional healers</topic><topic>traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duncan, Andrew C</creatorcontrib><creatorcontrib>Jäger, Anna K</creatorcontrib><creatorcontrib>van Staden, Johannes</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duncan, Andrew C</au><au>Jäger, Anna K</au><au>van Staden, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening of Zulu medicinal plants for angiotensin converting enzyme (ACE) inhibitors</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>1999-12-15</date><risdate>1999</risdate><volume>68</volume><issue>1</issue><spage>63</spage><epage>70</epage><pages>63-70</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Twenty plants used by traditional healers in South Africa for the treatment of high blood pressure were investigated for their anti-hypertensive properties, utilizing the angiotensin converting enzyme assay. A hit rate of 65% was achieved, with the highest inhibition (97%) obtained by
Adenopodia spicata leaves. A further seven plants exhibited an inhibition greater than 70% and five more over 50%. The leaves of the plants showed the greatest levels of inhibition. There was little difference in the overall hit rate between ethanolic and aqueous extracts, although in most cases there was a marked difference in activity between aqueous and ethanolic extracts from the same species. Plants exhibiting inhibition levels greater than 50% were further tested for the presence of tannins in order to eliminate possible false positives. Active plants that did not contain tannins were
Agapanthus africanus, Agave americana, Clausena anisata, Dietes iridioides, Mesembruanthemum spp.,
Stangeria eriopus and
Tulbaghia
violacea.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10624863</pmid><doi>10.1016/S0378-8741(99)00097-5</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Angiotensin converting enzyme Angiotensin-Converting Enzyme Inhibitors - pharmacology Antihypertensive Agents - analysis Biological and medical sciences Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods False Positive Reactions General pharmacology Hypertension Medical sciences Medicinal plants Medicine, Traditional Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plants, Medicinal - chemistry Solubility South Africa Tannins - analysis Time Factors Traditional healers traditional medicine |
| title | Screening of Zulu medicinal plants for angiotensin converting enzyme (ACE) inhibitors |
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