The Co‐Crystal Approach to Improve the Exposure of a Water‐Insoluble Compound: AMG 517 Sorbic Acid Co‐Crystal Characterization and Pharmacokinetics

Co‐crystals are relatively novel in the pharmaceutical field and are not reported extensively. AMG 517 is an insoluble small molecule VR1 (vanilloid receptor 1) antagonist. In animal studies, good exposure of AMG 517 is seen from a 10% (w/v) Pluronic® F108 in OraPlus® suspension. Investigation of th...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2008-09, Vol.97 (9), p.3942-3956
Hauptverfasser:	Bak, Annette, Gore, Anu, Yanez, Evelyn, Stanton, Mary, Tufekcic, Sunita, Syed, Rashid, Akrami, Anna, Rose, Mark, Surapaneni, Sekhar, Bostick, Tracy, King, Anthony, Neervannan, Sesha, Ostovic, Drazen, Koparkar, Arun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzothiazoles - blood Benzothiazoles - chemistry Benzothiazoles - pharmacokinetics bioavailability Biological and medical sciences Chromatography, High Pressure Liquid co-crystals Crystallization Crystallography, X-Ray General pharmacology Magnetic Resonance Spectroscopy Medical sciences Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments physical characterization physical stability physicochemical properties Pyrimidines - blood Pyrimidines - chemistry Pyrimidines - pharmacokinetics Rats Rats, Sprague-Dawley Solubility TRPV Cation Channels - antagonists & inhibitors Water - chemistry
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