Secondary ischaemia in experimental free flaps – treatment by long acting prostacyclin analogues

Secondary postoperative ischaemia due to venous occlusion is the most detrimental insult to free microvascular flaps. In an experimental rat free flap model the efficacy of long acting prostacyclin analogues iloprost (Ilomedin™) and cicaprost in venous occlusion induced postoperative ischaemia was s...

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Veröffentlicht in:	British journal of plastic surgery 1999-07, Vol.52 (5), p.392-398
Hauptverfasser:	Frick, A., Baumeister, R.G.H., Menger, M.D., Vollmar, B., Wohllaib, U., Wiebecke, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Epoprostenol - analogs & derivatives Epoprostenol - therapeutic use Graft Rejection - prevention & control Iloprost - therapeutic use Ischemia - drug therapy Male Medical sciences microvascular free flap, secondary ischaemia, venous occlusion, prostacyclin analogues, experimental rat groin flaps, iloprost, cisaprost Miscellaneous Oxygen - blood Partial Pressure Postoperative Complications - drug therapy Prostaglandins, Synthetic - therapeutic use Rats Rats, Sprague-Dawley Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Flaps - blood supply Vasodilator Agents - therapeutic use
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