Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line
Apoptosis is a new therapeutic target of cancer research. Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE , a traditional oriental medical herb, was observed to induce apoptosis in HL60 human premyelocytic leukemia cell line. Tanshinone IIA induced DNA fragmentation into the multiples of 180...
Gespeichert in:
| Veröffentlicht in: | Journal of ethnopharmacology 1999-12, Vol.68 (1), p.121-127 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 127 |
|---|---|
| container_issue | 1 |
| container_start_page | 121 |
| container_title | Journal of ethnopharmacology |
| container_volume | 68 |
| creator | Yoon, Yoosik Kim, Yeon-Ok Jeon, Won-Kyung Park, Hee-Juhn Sung, Hyun Jea |
| description | Apoptosis is a new therapeutic target of cancer research. Tanshinone IIA isolated from
Salvia miltiorrhiza BUNGE
, a traditional oriental medical herb, was observed to induce apoptosis in HL60 human premyelocytic leukemia cell line. Tanshinone IIA induced DNA fragmentation into the multiples of 180 bp and increased the percentage of hypodiploid cells in flow cytometry after propidium iodide (PI) staining. Tanshinone IIA-induced apoptosis is accompanied by the specific proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and the activation of caspase-3, a major component in apoptotic cell death mechanism. |
| doi_str_mv | 10.1016/S0378-8741(99)00059-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69393359</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874199000598</els_id><sourcerecordid>69393359</sourcerecordid><originalsourceid>FETCH-LOGICAL-c532t-cbc48b3c48fcbab2ac13ecf174b864155c13f1297354f8deb4a56ef6c7d744333</originalsourceid><addsrcrecordid>eNqF0UGP1CAUB3BiNO64-hFUDsbooQqFlnIy62bdnWSih9k5E0ofDkpLhXbN-OllthP15gUC-b3Hyx-EnlPyjhJav98SJpqiEZy-kfItIaSSRfMArWgjykJUgj1Eqz_kDD1J6VtGgnLyGJ1RUpe8EXSFft7qIe3dEAbA6_UFdil4PUGHbQw93mp_5zTunZ9ciHHvfmn8cff5-gq7oZtNZnoM4xSSS_kG32xqgvdzrwc8RugP4IM5TM5gD_N36HMnA95j7wZ4ih5Z7RM8O-3naPfp6vbypth8uV5fXmwKU7FyKkxreNOyvFjT6rbUhjIwlgreNjWnVZXPlpZSsIrbpoOW66oGWxvRCc4ZY-fo9dJ3jOHHDGlSvUvHKfQAYU6qlkwyVskMqwWaGFKKYNUYXa_jQVGijomr-8TVMU4lpbpPXDW57sXpgbntofunaok4g1cnoJPR3kY9GJf-OtrUgvDMXi7M6qD015jJblsSykgpGRfiOOGHRUDO685BVMk4GPIvuAhmUl1w_5n1N88gp3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69393359</pqid></control><display><type>article</type><title>Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Yoon, Yoosik ; Kim, Yeon-Ok ; Jeon, Won-Kyung ; Park, Hee-Juhn ; Sung, Hyun Jea</creator><creatorcontrib>Yoon, Yoosik ; Kim, Yeon-Ok ; Jeon, Won-Kyung ; Park, Hee-Juhn ; Sung, Hyun Jea</creatorcontrib><description>Apoptosis is a new therapeutic target of cancer research. Tanshinone IIA isolated from
Salvia miltiorrhiza BUNGE
, a traditional oriental medical herb, was observed to induce apoptosis in HL60 human premyelocytic leukemia cell line. Tanshinone IIA induced DNA fragmentation into the multiples of 180 bp and increased the percentage of hypodiploid cells in flow cytometry after propidium iodide (PI) staining. Tanshinone IIA-induced apoptosis is accompanied by the specific proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and the activation of caspase-3, a major component in apoptotic cell death mechanism.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/S0378-8741(99)00059-8</identifier><identifier>PMID: 10624871</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Antineoplastic Agents, Phytogenic - therapeutic use ; Apoptosis ; Apoptosis - drug effects ; Biological and medical sciences ; Caspase ; Caspase 3 ; Caspases - metabolism ; Coloring Agents - chemistry ; Diterpenes, Abietane ; DNA Fragmentation - drug effects ; Drugs, Chinese Herbal - therapeutic use ; Flow Cytometry ; General pharmacology ; Humans ; In Vitro Techniques ; Leukemia, Myeloid - drug therapy ; Leukemia, Myeloid - pathology ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenanthrenes - therapeutic use ; Plant Extracts - therapeutic use ; Poly(ADP-ribose) Polymerases - drug effects ; Propidium - chemistry ; Salvia miltiorrhiza BUNGE ; Tanshinone IIA ; Time Factors ; traditional medicine ; Tumor Cells, Cultured</subject><ispartof>Journal of ethnopharmacology, 1999-12, Vol.68 (1), p.121-127</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-cbc48b3c48fcbab2ac13ecf174b864155c13f1297354f8deb4a56ef6c7d744333</citedby><cites>FETCH-LOGICAL-c532t-cbc48b3c48fcbab2ac13ecf174b864155c13f1297354f8deb4a56ef6c7d744333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-8741(99)00059-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1186704$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10624871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, Yoosik</creatorcontrib><creatorcontrib>Kim, Yeon-Ok</creatorcontrib><creatorcontrib>Jeon, Won-Kyung</creatorcontrib><creatorcontrib>Park, Hee-Juhn</creatorcontrib><creatorcontrib>Sung, Hyun Jea</creatorcontrib><title>Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Apoptosis is a new therapeutic target of cancer research. Tanshinone IIA isolated from
Salvia miltiorrhiza BUNGE
, a traditional oriental medical herb, was observed to induce apoptosis in HL60 human premyelocytic leukemia cell line. Tanshinone IIA induced DNA fragmentation into the multiples of 180 bp and increased the percentage of hypodiploid cells in flow cytometry after propidium iodide (PI) staining. Tanshinone IIA-induced apoptosis is accompanied by the specific proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and the activation of caspase-3, a major component in apoptotic cell death mechanism.</description><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Caspase</subject><subject>Caspase 3</subject><subject>Caspases - metabolism</subject><subject>Coloring Agents - chemistry</subject><subject>Diterpenes, Abietane</subject><subject>DNA Fragmentation - drug effects</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Flow Cytometry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Leukemia, Myeloid - drug therapy</subject><subject>Leukemia, Myeloid - pathology</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenanthrenes - therapeutic use</subject><subject>Plant Extracts - therapeutic use</subject><subject>Poly(ADP-ribose) Polymerases - drug effects</subject><subject>Propidium - chemistry</subject><subject>Salvia miltiorrhiza BUNGE</subject><subject>Tanshinone IIA</subject><subject>Time Factors</subject><subject>traditional medicine</subject><subject>Tumor Cells, Cultured</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UGP1CAUB3BiNO64-hFUDsbooQqFlnIy62bdnWSih9k5E0ofDkpLhXbN-OllthP15gUC-b3Hyx-EnlPyjhJav98SJpqiEZy-kfItIaSSRfMArWgjykJUgj1Eqz_kDD1J6VtGgnLyGJ1RUpe8EXSFft7qIe3dEAbA6_UFdil4PUGHbQw93mp_5zTunZ9ciHHvfmn8cff5-gq7oZtNZnoM4xSSS_kG32xqgvdzrwc8RugP4IM5TM5gD_N36HMnA95j7wZ4ih5Z7RM8O-3naPfp6vbypth8uV5fXmwKU7FyKkxreNOyvFjT6rbUhjIwlgreNjWnVZXPlpZSsIrbpoOW66oGWxvRCc4ZY-fo9dJ3jOHHDGlSvUvHKfQAYU6qlkwyVskMqwWaGFKKYNUYXa_jQVGijomr-8TVMU4lpbpPXDW57sXpgbntofunaok4g1cnoJPR3kY9GJf-OtrUgvDMXi7M6qD015jJblsSykgpGRfiOOGHRUDO685BVMk4GPIvuAhmUl1w_5n1N88gp3w</recordid><startdate>19991215</startdate><enddate>19991215</enddate><creator>Yoon, Yoosik</creator><creator>Kim, Yeon-Ok</creator><creator>Jeon, Won-Kyung</creator><creator>Park, Hee-Juhn</creator><creator>Sung, Hyun Jea</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991215</creationdate><title>Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line</title><author>Yoon, Yoosik ; Kim, Yeon-Ok ; Jeon, Won-Kyung ; Park, Hee-Juhn ; Sung, Hyun Jea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-cbc48b3c48fcbab2ac13ecf174b864155c13f1297354f8deb4a56ef6c7d744333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Caspase</topic><topic>Caspase 3</topic><topic>Caspases - metabolism</topic><topic>Coloring Agents - chemistry</topic><topic>Diterpenes, Abietane</topic><topic>DNA Fragmentation - drug effects</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Flow Cytometry</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Leukemia, Myeloid - drug therapy</topic><topic>Leukemia, Myeloid - pathology</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenanthrenes - therapeutic use</topic><topic>Plant Extracts - therapeutic use</topic><topic>Poly(ADP-ribose) Polymerases - drug effects</topic><topic>Propidium - chemistry</topic><topic>Salvia miltiorrhiza BUNGE</topic><topic>Tanshinone IIA</topic><topic>Time Factors</topic><topic>traditional medicine</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, Yoosik</creatorcontrib><creatorcontrib>Kim, Yeon-Ok</creatorcontrib><creatorcontrib>Jeon, Won-Kyung</creatorcontrib><creatorcontrib>Park, Hee-Juhn</creatorcontrib><creatorcontrib>Sung, Hyun Jea</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, Yoosik</au><au>Kim, Yeon-Ok</au><au>Jeon, Won-Kyung</au><au>Park, Hee-Juhn</au><au>Sung, Hyun Jea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>1999-12-15</date><risdate>1999</risdate><volume>68</volume><issue>1</issue><spage>121</spage><epage>127</epage><pages>121-127</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Apoptosis is a new therapeutic target of cancer research. Tanshinone IIA isolated from
Salvia miltiorrhiza BUNGE
, a traditional oriental medical herb, was observed to induce apoptosis in HL60 human premyelocytic leukemia cell line. Tanshinone IIA induced DNA fragmentation into the multiples of 180 bp and increased the percentage of hypodiploid cells in flow cytometry after propidium iodide (PI) staining. Tanshinone IIA-induced apoptosis is accompanied by the specific proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and the activation of caspase-3, a major component in apoptotic cell death mechanism.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10624871</pmid><doi>10.1016/S0378-8741(99)00059-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 1999-12, Vol.68 (1), p.121-127 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69393359 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis Apoptosis - drug effects Biological and medical sciences Caspase Caspase 3 Caspases - metabolism Coloring Agents - chemistry Diterpenes, Abietane DNA Fragmentation - drug effects Drugs, Chinese Herbal - therapeutic use Flow Cytometry General pharmacology Humans In Vitro Techniques Leukemia, Myeloid - drug therapy Leukemia, Myeloid - pathology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenanthrenes - therapeutic use Plant Extracts - therapeutic use Poly(ADP-ribose) Polymerases - drug effects Propidium - chemistry Salvia miltiorrhiza BUNGE Tanshinone IIA Time Factors traditional medicine Tumor Cells, Cultured |
| title | Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T11%3A17%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tanshinone%20IIA%20isolated%20from%20Salvia%20miltiorrhiza%20BUNGE%20induced%20apoptosis%20in%20HL60%20human%20premyelocytic%20leukemia%20cell%20line&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Yoon,%20Yoosik&rft.date=1999-12-15&rft.volume=68&rft.issue=1&rft.spage=121&rft.epage=127&rft.pages=121-127&rft.issn=0378-8741&rft.eissn=1872-7573&rft.coden=JOETD7&rft_id=info:doi/10.1016/S0378-8741(99)00059-8&rft_dat=%3Cproquest_cross%3E69393359%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69393359&rft_id=info:pmid/10624871&rft_els_id=S0378874199000598&rfr_iscdi=true |