Structural changes in the promoter region mediate transvection at the sn-glycerol-3-phosphate dehydrogenase gene of Drosophila melanogaster. [Errata: Apr 2000, v. 38 (3/4), p. 109-110 and June 2000, v. 38 (5/6), p. 201-202.]
Trans effects at the sn-glycerol-3-phosphate dehydrogenase locus (Gpdh) of Drosophila melanogaster give rise to an increase in GPDH activity and mRNA from the wild-type allele in heterozygotes with some low-activity alleles. Either the low-activity alleles that induce the effect have a defective P-e...
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| Veröffentlicht in: | Biochemical genetics 1999-10, Vol.37 (9/10), p.301-315 |
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| creator | Gibson, J.B Reed, D.S Bartoszewski, S Wilks, A.V |
| description | Trans effects at the sn-glycerol-3-phosphate dehydrogenase locus (Gpdh) of Drosophila melanogaster give rise to an increase in GPDH activity and mRNA from the wild-type allele in heterozygotes with some low-activity alleles. Either the low-activity alleles that induce the effect have a defective P-element inserted between the promoter and a downstream intronic enhancer element or the promoter region is deleted. The trans effect is pairing dependent, characteristic of transvection at some other loci. The defective P-elements that mediate transvection are located between the promoter and at least up to 6 bp downstream of the transcription start site. Transvection at Gpdh appears similar to the "enhancer action in trans" mode at the yellow locus. |
| doi_str_mv | 10.1023/A:1018707226595 |
| format | Article |
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[Errata: Apr 2000, v. 38 (3/4), p. 109-110 and June 2000, v. 38 (5/6), p. 201-202.]</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Gibson, J.B ; Reed, D.S ; Bartoszewski, S ; Wilks, A.V</creator><creatorcontrib>Gibson, J.B ; Reed, D.S ; Bartoszewski, S ; Wilks, A.V</creatorcontrib><description>Trans effects at the sn-glycerol-3-phosphate dehydrogenase locus (Gpdh) of Drosophila melanogaster give rise to an increase in GPDH activity and mRNA from the wild-type allele in heterozygotes with some low-activity alleles. Either the low-activity alleles that induce the effect have a defective P-element inserted between the promoter and a downstream intronic enhancer element or the promoter region is deleted. The trans effect is pairing dependent, characteristic of transvection at some other loci. The defective P-elements that mediate transvection are located between the promoter and at least up to 6 bp downstream of the transcription start site. Transvection at Gpdh appears similar to the "enhancer action in trans" mode at the yellow locus.</description><identifier>ISSN: 0006-2928</identifier><identifier>EISSN: 1573-4927</identifier><identifier>DOI: 10.1023/A:1018707226595</identifier><identifier>PMID: 10626038</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Base Sequence ; Blotting, Northern ; dehydrogenase ; DNA Transposable Elements ; DNA-Binding Proteins - genetics ; Drosophila melanogaster ; Drosophila melanogaster - genetics ; Drosophila Proteins ; Enhancers ; Female ; Gdph gene ; genes ; Glycerolphosphate Dehydrogenase - genetics ; Glycerolphosphate Dehydrogenase - metabolism ; Heterozygote ; Insect Proteins - genetics ; Insect Proteins - metabolism ; Male ; Molecular Sequence Data ; P elements ; promoter regions ; Promoter Regions, Genetic ; Promoters ; RNA, Messenger ; Transcription ; Transcription, Genetic ; transposon P ; yellow gene</subject><ispartof>Biochemical genetics, 1999-10, Vol.37 (9/10), p.301-315</ispartof><rights>Plenum Publishing Corporation 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-1ea641411e12f197b3c2ba7b5cd0a3c571cb97c61ee5780b6f8e94e088cc2b6b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10626038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gibson, J.B</creatorcontrib><creatorcontrib>Reed, D.S</creatorcontrib><creatorcontrib>Bartoszewski, S</creatorcontrib><creatorcontrib>Wilks, A.V</creatorcontrib><title>Structural changes in the promoter region mediate transvection at the sn-glycerol-3-phosphate dehydrogenase gene of Drosophila melanogaster. [Errata: Apr 2000, v. 38 (3/4), p. 109-110 and June 2000, v. 38 (5/6), p. 201-202.]</title><title>Biochemical genetics</title><addtitle>Biochem Genet</addtitle><description>Trans effects at the sn-glycerol-3-phosphate dehydrogenase locus (Gpdh) of Drosophila melanogaster give rise to an increase in GPDH activity and mRNA from the wild-type allele in heterozygotes with some low-activity alleles. Either the low-activity alleles that induce the effect have a defective P-element inserted between the promoter and a downstream intronic enhancer element or the promoter region is deleted. The trans effect is pairing dependent, characteristic of transvection at some other loci. The defective P-elements that mediate transvection are located between the promoter and at least up to 6 bp downstream of the transcription start site. Transvection at Gpdh appears similar to the "enhancer action in trans" mode at the yellow locus.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Blotting, Northern</subject><subject>dehydrogenase</subject><subject>DNA Transposable Elements</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila Proteins</subject><subject>Enhancers</subject><subject>Female</subject><subject>Gdph gene</subject><subject>genes</subject><subject>Glycerolphosphate Dehydrogenase - genetics</subject><subject>Glycerolphosphate Dehydrogenase - metabolism</subject><subject>Heterozygote</subject><subject>Insect Proteins - genetics</subject><subject>Insect Proteins - metabolism</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>P elements</subject><subject>promoter regions</subject><subject>Promoter Regions, Genetic</subject><subject>Promoters</subject><subject>RNA, Messenger</subject><subject>Transcription</subject><subject>Transcription, Genetic</subject><subject>transposon P</subject><subject>yellow gene</subject><issn>0006-2928</issn><issn>1573-4927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0k1v1DAQBuAIgWgpnLmBxQEVqdkd2_FXb6tSvlSJQ-kJocjxziapsnGwnUr7b_kpeNlygAOcRrYevfaMXRTPKSwoML5cnVOgWoFiTAojHhTHVCheVoaph8UxAMiSGaaPiicx3ualgap6XBxRkEwC18fFj-sUZpfmYAfiOju2GEk_ktQhmYLf-oSBBGx7P5ItrnubkKRgx3iHLu03bfpl41i2w85h8EPJy6nzcer2do3dbh18i6ONSHJB4jfkbfDRT10_2Bw62NG3NuaDFuTrZQg22XOymgJh-b5n5G5BuCanfFm9OSPTglAwJaVA7Lgmn-ac9wcTS3lgDGjJgC2-PS0ebewQ8dl9PSlu3l1-ufhQXn1-__FidVU6LnUqKVpZ0YpSpGxDjWq4Y41VjXBrsNwJRV1jlJMUUSgNjdxoNBWC1i5D2fCT4vUhN4_t-4wx1ds-Ohxye-jnWEvDDaso-y-kquIKpMrw9N8QeKVZJdU-89Vf9NbPYcz91koYACHNPu_FPZqb_Jb1FPqtDbv692fI4OUBbKyvbRv6WN9c50FyYEYILQT_CRo8uPw</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Gibson, J.B</creator><creator>Reed, D.S</creator><creator>Bartoszewski, S</creator><creator>Wilks, A.V</creator><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Structural changes in the promoter region mediate transvection at the sn-glycerol-3-phosphate dehydrogenase gene of Drosophila melanogaster. [Errata: Apr 2000, v. 38 (3/4), p. 109-110 and June 2000, v. 38 (5/6), p. 201-202.]</title><author>Gibson, J.B ; Reed, D.S ; Bartoszewski, S ; Wilks, A.V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-1ea641411e12f197b3c2ba7b5cd0a3c571cb97c61ee5780b6f8e94e088cc2b6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Blotting, Northern</topic><topic>dehydrogenase</topic><topic>DNA Transposable Elements</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila Proteins</topic><topic>Enhancers</topic><topic>Female</topic><topic>Gdph gene</topic><topic>genes</topic><topic>Glycerolphosphate Dehydrogenase - genetics</topic><topic>Glycerolphosphate Dehydrogenase - metabolism</topic><topic>Heterozygote</topic><topic>Insect Proteins - genetics</topic><topic>Insect Proteins - metabolism</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>P elements</topic><topic>promoter regions</topic><topic>Promoter Regions, Genetic</topic><topic>Promoters</topic><topic>RNA, Messenger</topic><topic>Transcription</topic><topic>Transcription, Genetic</topic><topic>transposon P</topic><topic>yellow gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibson, J.B</creatorcontrib><creatorcontrib>Reed, D.S</creatorcontrib><creatorcontrib>Bartoszewski, S</creatorcontrib><creatorcontrib>Wilks, A.V</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibson, J.B</au><au>Reed, D.S</au><au>Bartoszewski, S</au><au>Wilks, A.V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural changes in the promoter region mediate transvection at the sn-glycerol-3-phosphate dehydrogenase gene of Drosophila melanogaster. [Errata: Apr 2000, v. 38 (3/4), p. 109-110 and June 2000, v. 38 (5/6), p. 201-202.]</atitle><jtitle>Biochemical genetics</jtitle><addtitle>Biochem Genet</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>37</volume><issue>9/10</issue><spage>301</spage><epage>315</epage><pages>301-315</pages><issn>0006-2928</issn><eissn>1573-4927</eissn><abstract>Trans effects at the sn-glycerol-3-phosphate dehydrogenase locus (Gpdh) of Drosophila melanogaster give rise to an increase in GPDH activity and mRNA from the wild-type allele in heterozygotes with some low-activity alleles. Either the low-activity alleles that induce the effect have a defective P-element inserted between the promoter and a downstream intronic enhancer element or the promoter region is deleted. The trans effect is pairing dependent, characteristic of transvection at some other loci. 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| issn | 0006-2928 1573-4927 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Base Sequence Blotting, Northern dehydrogenase DNA Transposable Elements DNA-Binding Proteins - genetics Drosophila melanogaster Drosophila melanogaster - genetics Drosophila Proteins Enhancers Female Gdph gene genes Glycerolphosphate Dehydrogenase - genetics Glycerolphosphate Dehydrogenase - metabolism Heterozygote Insect Proteins - genetics Insect Proteins - metabolism Male Molecular Sequence Data P elements promoter regions Promoter Regions, Genetic Promoters RNA, Messenger Transcription Transcription, Genetic transposon P yellow gene |
| title | Structural changes in the promoter region mediate transvection at the sn-glycerol-3-phosphate dehydrogenase gene of Drosophila melanogaster. [Errata: Apr 2000, v. 38 (3/4), p. 109-110 and June 2000, v. 38 (5/6), p. 201-202.] |
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