Schizophrenia and temporal lobe asymmetry. A post-mortem stereological study of tissue volume
A previous report by Crow of a left-sided increase in temporal horn volume in schizophrenia implies a left-sided loss of tissue. To elucidate the structural nature of schizophrenia. The volume of grey matter in the temporal pole and inferior, middle and superior temporal gyri was measured, in additi...
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| Veröffentlicht in: | British journal of psychiatry 1999-08, Vol.175 (2), p.127-134 |
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| creator | Highley, JR McDonald, B Walker, MA Esiri, MM Crow, TJ |
| description | A previous report by Crow of a left-sided increase in temporal horn volume in schizophrenia implies a left-sided loss of tissue.
To elucidate the structural nature of schizophrenia.
The volume of grey matter in the temporal pole and inferior, middle and superior temporal gyri was measured, in addition to the total volume of grey and white matter, in the temporal lobes of the brains of 29 patients with schizophrenia and 27 controls.
We found a significant left-sided reduction in the superior temporal gyrus in both males and females with schizophrenia, which was related to increasing age of onset in the males. The total volume of temporal lobe grey and white matter was also significantly reduced. Although being more marked on the left than the right, the lateralisation for these total grey and white measures (by contrast with the superior temporal gyrus alone) did not attain formal statistical significance.
Confirmation of a lateralised reduction in the superior temporal gyrus, which is differentially related to age of onset according to gender, adds to evidence that the changes in schizophrenia are in systems that are lateralised. The findings implicate language as the relevant function. |
| doi_str_mv | 10.1192/bjp.175.2.127 |
| format | Article |
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To elucidate the structural nature of schizophrenia.
The volume of grey matter in the temporal pole and inferior, middle and superior temporal gyri was measured, in addition to the total volume of grey and white matter, in the temporal lobes of the brains of 29 patients with schizophrenia and 27 controls.
We found a significant left-sided reduction in the superior temporal gyrus in both males and females with schizophrenia, which was related to increasing age of onset in the males. The total volume of temporal lobe grey and white matter was also significantly reduced. Although being more marked on the left than the right, the lateralisation for these total grey and white measures (by contrast with the superior temporal gyrus alone) did not attain formal statistical significance.
Confirmation of a lateralised reduction in the superior temporal gyrus, which is differentially related to age of onset according to gender, adds to evidence that the changes in schizophrenia are in systems that are lateralised. The findings implicate language as the relevant function.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.175.2.127</identifier><identifier>PMID: 10627794</identifier><language>eng</language><publisher>England: RCP</publisher><subject>Adult ; Age differences ; Age of Onset ; Aged ; Autopsy ; Brain Diseases - pathology ; Female ; Gender ; Hemispheric laterality ; Humans ; Male ; Mental disorders ; Middle Aged ; Parahippocampal Gyrus - pathology ; Schizophrenia ; Schizophrenia - pathology ; Sensitivity and Specificity ; Sex Distribution ; Substantia alba ; Substantia grisea ; Superior temporal gyrus ; Temporal gyrus ; Temporal lobe ; Temporal Lobe - pathology ; Temporal lobes</subject><ispartof>British journal of psychiatry, 1999-08, Vol.175 (2), p.127-134</ispartof><rights>Copyright © 1999 The Royal College of Psychiatrists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c299t-a4b9d8e896ae4f5b49fcf2ede65693dd4047538587eaa4ac24647ca2a01b8e8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,12846,27924,27925,30999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10627794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Highley, JR</creatorcontrib><creatorcontrib>McDonald, B</creatorcontrib><creatorcontrib>Walker, MA</creatorcontrib><creatorcontrib>Esiri, MM</creatorcontrib><creatorcontrib>Crow, TJ</creatorcontrib><title>Schizophrenia and temporal lobe asymmetry. A post-mortem stereological study of tissue volume</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>A previous report by Crow of a left-sided increase in temporal horn volume in schizophrenia implies a left-sided loss of tissue.
To elucidate the structural nature of schizophrenia.
The volume of grey matter in the temporal pole and inferior, middle and superior temporal gyri was measured, in addition to the total volume of grey and white matter, in the temporal lobes of the brains of 29 patients with schizophrenia and 27 controls.
We found a significant left-sided reduction in the superior temporal gyrus in both males and females with schizophrenia, which was related to increasing age of onset in the males. The total volume of temporal lobe grey and white matter was also significantly reduced. Although being more marked on the left than the right, the lateralisation for these total grey and white measures (by contrast with the superior temporal gyrus alone) did not attain formal statistical significance.
Confirmation of a lateralised reduction in the superior temporal gyrus, which is differentially related to age of onset according to gender, adds to evidence that the changes in schizophrenia are in systems that are lateralised. The findings implicate language as the relevant function.</description><subject>Adult</subject><subject>Age differences</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Autopsy</subject><subject>Brain Diseases - pathology</subject><subject>Female</subject><subject>Gender</subject><subject>Hemispheric laterality</subject><subject>Humans</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Parahippocampal Gyrus - pathology</subject><subject>Schizophrenia</subject><subject>Schizophrenia - pathology</subject><subject>Sensitivity and Specificity</subject><subject>Sex Distribution</subject><subject>Substantia alba</subject><subject>Substantia grisea</subject><subject>Superior temporal gyrus</subject><subject>Temporal gyrus</subject><subject>Temporal lobe</subject><subject>Temporal Lobe - pathology</subject><subject>Temporal lobes</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0EtLxDAYheEgijNelm4lIrhrza1NsxTxBoILdSkhTb9OO7STmrRK_fVGxoW4CoEnh_AidEJJSqlil-V6SKnMUpZSJnfQkgrJEirybBctCSEyoSwjC3QQwjpeuWByHy0oyZmUSizR27Nt2i83NB42rcFmU-ER-sF50-HOlYBNmPseRj-n-AoPLoxJ73wkOIzgwXVu1dpowzhVM3Y1HtsQJsAfrpt6OEJ7tekCHP-eh-j19ubl-j55fLp7uL56TCxTakyMKFVVQKFyA6LOSqFqWzOoIM9yxatKECEzXmSFBGOEsUzkQlrDDKFlfAb8EF1sdwfv3icIo-7bYKHrzAbcFHRcUZQoEuH5P7h2k9_Ev2nGC8UlV5xHlWyV9S4ED7UefNsbP2tK9E91HavrWF0zHatHf_q7OpU9VH_0NnMEZ1vQtKvms_WgvR3CbJs_I9-etooW</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>Highley, JR</creator><creator>McDonald, B</creator><creator>Walker, MA</creator><creator>Esiri, MM</creator><creator>Crow, TJ</creator><general>RCP</general><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19990801</creationdate><title>Schizophrenia and temporal lobe asymmetry. A post-mortem stereological study of tissue volume</title><author>Highley, JR ; McDonald, B ; Walker, MA ; Esiri, MM ; Crow, TJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-a4b9d8e896ae4f5b49fcf2ede65693dd4047538587eaa4ac24647ca2a01b8e8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Age differences</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Autopsy</topic><topic>Brain Diseases - pathology</topic><topic>Female</topic><topic>Gender</topic><topic>Hemispheric laterality</topic><topic>Humans</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Parahippocampal Gyrus - pathology</topic><topic>Schizophrenia</topic><topic>Schizophrenia - pathology</topic><topic>Sensitivity and Specificity</topic><topic>Sex Distribution</topic><topic>Substantia alba</topic><topic>Substantia grisea</topic><topic>Superior temporal gyrus</topic><topic>Temporal gyrus</topic><topic>Temporal lobe</topic><topic>Temporal Lobe - pathology</topic><topic>Temporal lobes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Highley, JR</creatorcontrib><creatorcontrib>McDonald, B</creatorcontrib><creatorcontrib>Walker, MA</creatorcontrib><creatorcontrib>Esiri, MM</creatorcontrib><creatorcontrib>Crow, TJ</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Psychology Journals</collection><collection>ProQuest Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Highley, JR</au><au>McDonald, B</au><au>Walker, MA</au><au>Esiri, MM</au><au>Crow, TJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Schizophrenia and temporal lobe asymmetry. A post-mortem stereological study of tissue volume</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>175</volume><issue>2</issue><spage>127</spage><epage>134</epage><pages>127-134</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>A previous report by Crow of a left-sided increase in temporal horn volume in schizophrenia implies a left-sided loss of tissue.
To elucidate the structural nature of schizophrenia.
The volume of grey matter in the temporal pole and inferior, middle and superior temporal gyri was measured, in addition to the total volume of grey and white matter, in the temporal lobes of the brains of 29 patients with schizophrenia and 27 controls.
We found a significant left-sided reduction in the superior temporal gyrus in both males and females with schizophrenia, which was related to increasing age of onset in the males. The total volume of temporal lobe grey and white matter was also significantly reduced. Although being more marked on the left than the right, the lateralisation for these total grey and white measures (by contrast with the superior temporal gyrus alone) did not attain formal statistical significance.
Confirmation of a lateralised reduction in the superior temporal gyrus, which is differentially related to age of onset according to gender, adds to evidence that the changes in schizophrenia are in systems that are lateralised. The findings implicate language as the relevant function.</abstract><cop>England</cop><pub>RCP</pub><pmid>10627794</pmid><doi>10.1192/bjp.175.2.127</doi><tpages>8</tpages></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Cambridge University Press Journals Complete |
| subjects | Adult Age differences Age of Onset Aged Autopsy Brain Diseases - pathology Female Gender Hemispheric laterality Humans Male Mental disorders Middle Aged Parahippocampal Gyrus - pathology Schizophrenia Schizophrenia - pathology Sensitivity and Specificity Sex Distribution Substantia alba Substantia grisea Superior temporal gyrus Temporal gyrus Temporal lobe Temporal Lobe - pathology Temporal lobes |
| title | Schizophrenia and temporal lobe asymmetry. A post-mortem stereological study of tissue volume |
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