Spontaneous and induced release of prostaglandins, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha by placental tissue from normal and preeclamptic pregnancies
The objective of this study was to clarify the role of the main proinflammatory cytokines (interleukin [IL]-1, IL-6, tumor necrosis factor [TNF]-alpha) in the pathogenesis of preeclampsia and how these cytokines affect one another and the production of prostaglandins (PGs). The concentrations of cyt...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 1999-12, Vol.42 (6), p.369-374 |
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| container_title | American journal of reproductive immunology (1989) |
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| creator | Munno, I Chiechi, L M Lacedra, G Putignano, G Patimo, C Lobascio, A Loizzi, P |
| description | The objective of this study was to clarify the role of the main proinflammatory cytokines (interleukin [IL]-1, IL-6, tumor necrosis factor [TNF]-alpha) in the pathogenesis of preeclampsia and how these cytokines affect one another and the production of prostaglandins (PGs).
The concentrations of cytokines and PGs in supernatants of placental tissue from preeclamptic and normal women were determined by enzyme-linked immunosorbent assay.
The concentrations of the PGs from unstimulated preeclamptic placental tissue were significantly higher compared to the concentrations of PGs from normal unstimulated placental tissue. Significant levels of IL-1beta were observed only in the supernatants of preeclamptic placental tissue. Of interest, an increase in TNF-alpha production was detected in the supernatants of IL-1-stimulated preeclamptic placental tissue.
The overproduction of TNF-alpha may be related not only to the effect of a stimulant like IL-1beta, but mainly to the lack of mechanisms down-regulating the production of TNF-alpha. |
| format | Article |
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The concentrations of cytokines and PGs in supernatants of placental tissue from preeclamptic and normal women were determined by enzyme-linked immunosorbent assay.
The concentrations of the PGs from unstimulated preeclamptic placental tissue were significantly higher compared to the concentrations of PGs from normal unstimulated placental tissue. Significant levels of IL-1beta were observed only in the supernatants of preeclamptic placental tissue. Of interest, an increase in TNF-alpha production was detected in the supernatants of IL-1-stimulated preeclamptic placental tissue.
The overproduction of TNF-alpha may be related not only to the effect of a stimulant like IL-1beta, but mainly to the lack of mechanisms down-regulating the production of TNF-alpha.</description><identifier>ISSN: 1046-7408</identifier><identifier>PMID: 10622467</identifier><language>eng</language><publisher>Denmark</publisher><subject>Dinoprost - analysis ; Dinoprostone - analysis ; Female ; Humans ; Interleukin-1 - analysis ; Interleukin-6 - analysis ; Placenta - immunology ; Pre-Eclampsia - immunology ; Pregnancy ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>American journal of reproductive immunology (1989), 1999-12, Vol.42 (6), p.369-374</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10622467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Munno, I</creatorcontrib><creatorcontrib>Chiechi, L M</creatorcontrib><creatorcontrib>Lacedra, G</creatorcontrib><creatorcontrib>Putignano, G</creatorcontrib><creatorcontrib>Patimo, C</creatorcontrib><creatorcontrib>Lobascio, A</creatorcontrib><creatorcontrib>Loizzi, P</creatorcontrib><title>Spontaneous and induced release of prostaglandins, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha by placental tissue from normal and preeclamptic pregnancies</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>The objective of this study was to clarify the role of the main proinflammatory cytokines (interleukin [IL]-1, IL-6, tumor necrosis factor [TNF]-alpha) in the pathogenesis of preeclampsia and how these cytokines affect one another and the production of prostaglandins (PGs).
The concentrations of cytokines and PGs in supernatants of placental tissue from preeclamptic and normal women were determined by enzyme-linked immunosorbent assay.
The concentrations of the PGs from unstimulated preeclamptic placental tissue were significantly higher compared to the concentrations of PGs from normal unstimulated placental tissue. Significant levels of IL-1beta were observed only in the supernatants of preeclamptic placental tissue. Of interest, an increase in TNF-alpha production was detected in the supernatants of IL-1-stimulated preeclamptic placental tissue.
The overproduction of TNF-alpha may be related not only to the effect of a stimulant like IL-1beta, but mainly to the lack of mechanisms down-regulating the production of TNF-alpha.</description><subject>Dinoprost - analysis</subject><subject>Dinoprostone - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-1 - analysis</subject><subject>Interleukin-6 - analysis</subject><subject>Placenta - immunology</subject><subject>Pre-Eclampsia - immunology</subject><subject>Pregnancy</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>1046-7408</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UMtOwzAQzAFES-EXkE8IpEayYydOjqjiUSkSB3qPHGddDI4dbOfAR_GPuLScVrM7M6uZs2xJMKtyznC9yC5D-MAY1w3lF9mC4KooWMWX2c_b5GwUFtwckLAD0naYJQzIgwERADmFJu9CFHuTztqGdaJE8AbmT23R3ba9z0kPUazRts2r9Z9JnEfnkQWZlDogJWR0Phdmeheo_0aTERLSV4OiDmEGpLwbkXV-TKuDfvIA0ohxiloewN4KKzWEq-xcCRPg-jRX2e7pcbd5ydvX5-3moc2nkvGc96SkRNSqZCmy7KuyKQqFWS0KqBkeKE9I8boCzHhTUyUUl2UpewbACanoKrs92qbkXzOE2I06SDDm2FNXNbQhmDaJeHMizv0IQzd5PQr_3f33S38B2Sh4Mw</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>Munno, I</creator><creator>Chiechi, L M</creator><creator>Lacedra, G</creator><creator>Putignano, G</creator><creator>Patimo, C</creator><creator>Lobascio, A</creator><creator>Loizzi, P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199912</creationdate><title>Spontaneous and induced release of prostaglandins, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha by placental tissue from normal and preeclamptic pregnancies</title><author>Munno, I ; Chiechi, L M ; Lacedra, G ; Putignano, G ; Patimo, C ; Lobascio, A ; Loizzi, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p547-7b1531a8f54000cb65922f048a2e840d372f0f786e047983faf7c55cb4ee71163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Dinoprost - analysis</topic><topic>Dinoprostone - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-1 - analysis</topic><topic>Interleukin-6 - analysis</topic><topic>Placenta - immunology</topic><topic>Pre-Eclampsia - immunology</topic><topic>Pregnancy</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Munno, I</creatorcontrib><creatorcontrib>Chiechi, L M</creatorcontrib><creatorcontrib>Lacedra, G</creatorcontrib><creatorcontrib>Putignano, G</creatorcontrib><creatorcontrib>Patimo, C</creatorcontrib><creatorcontrib>Lobascio, A</creatorcontrib><creatorcontrib>Loizzi, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munno, I</au><au>Chiechi, L M</au><au>Lacedra, G</au><au>Putignano, G</au><au>Patimo, C</au><au>Lobascio, A</au><au>Loizzi, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous and induced release of prostaglandins, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha by placental tissue from normal and preeclamptic pregnancies</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>1999-12</date><risdate>1999</risdate><volume>42</volume><issue>6</issue><spage>369</spage><epage>374</epage><pages>369-374</pages><issn>1046-7408</issn><abstract>The objective of this study was to clarify the role of the main proinflammatory cytokines (interleukin [IL]-1, IL-6, tumor necrosis factor [TNF]-alpha) in the pathogenesis of preeclampsia and how these cytokines affect one another and the production of prostaglandins (PGs).
The concentrations of cytokines and PGs in supernatants of placental tissue from preeclamptic and normal women were determined by enzyme-linked immunosorbent assay.
The concentrations of the PGs from unstimulated preeclamptic placental tissue were significantly higher compared to the concentrations of PGs from normal unstimulated placental tissue. Significant levels of IL-1beta were observed only in the supernatants of preeclamptic placental tissue. Of interest, an increase in TNF-alpha production was detected in the supernatants of IL-1-stimulated preeclamptic placental tissue.
The overproduction of TNF-alpha may be related not only to the effect of a stimulant like IL-1beta, but mainly to the lack of mechanisms down-regulating the production of TNF-alpha.</abstract><cop>Denmark</cop><pmid>10622467</pmid><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 1999-12, Vol.42 (6), p.369-374 |
| issn | 1046-7408 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69391039 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Dinoprost - analysis Dinoprostone - analysis Female Humans Interleukin-1 - analysis Interleukin-6 - analysis Placenta - immunology Pre-Eclampsia - immunology Pregnancy Tumor Necrosis Factor-alpha - analysis |
| title | Spontaneous and induced release of prostaglandins, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha by placental tissue from normal and preeclamptic pregnancies |
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