Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats
Depressed sarcoplasmic reticulum (SR) Ca²⁺-ATPase (SERCA2a) and Ca²⁺-release channels (ryanodine receptor RyR2) are involved in diabetic cardiomyopathy, however, the implication of intracellular calcium handling proteins in SR is undefined. It was hypothesized that the down-regulation of the intrace...
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| Veröffentlicht in: | Phytotherapy research 2008-08, Vol.22 (8), p.1107-1114 |
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| creator | He, Haibo Liu, Qiuju Shi, Mengqiong Zeng, Xiaowei Yang, Jun Wu, Limao Li, Lianda |
| description | Depressed sarcoplasmic reticulum (SR) Ca²⁺-ATPase (SERCA2a) and Ca²⁺-release channels (ryanodine receptor RyR2) are involved in diabetic cardiomyopathy, however, the implication of intracellular calcium handling proteins in SR is undefined. It was hypothesized that the down-regulation of the intracellular calcium handling proteins of SR is closely related to an up-regulated endothelin (ET) system. Hydroxysafflor yellow A (HSYA) is expected to ameliorate cardiac insufficiency which is mediated by the depressed intracellular calcium handling system in diabetic rat heart. Diabetes was produced in male rats 8 weeks after an injection of streptozotocin (60 mg/kg i.p.) and HSYA was administered (100 mg/kg) by gavage in the last 4 weeks. Hemodynamic and echocardiographic changes, cardiac calcium handling proteins, serum biochemistry, ET system and redox were measured. The compromised cardiac function in diabetic rats was accompanied by a significant down-regulation of the expression of RyR2, FKBP12.6 as well as SERCA2a and PLB. These were closely linked with oxidative stress, an increased ET-1 and up-regulation of ECE, PropreET-1 and iNOS mRNA in diabetic cardiomyopathy. After a 4 week treatment with HSYA, all abnormalities were reversed significantly. In conclusion, diabetic cardiomyopathy was correlated with an abnormal expression of calcium handing proteins in SR and an activated ET-ROS (reactive oxygen species) system in the diabetic affected myocardium. HSYA significantly improved the cardiac function and down-regulated the ET system and ROS pathway, resulting in a reversal of the abnormalities of expression of calcium handing proteins and the cardiac performance in diabetic cardiomyopathy. Copyright © 2008 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.2468 |
| format | Article |
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It was hypothesized that the down-regulation of the intracellular calcium handling proteins of SR is closely related to an up-regulated endothelin (ET) system. Hydroxysafflor yellow A (HSYA) is expected to ameliorate cardiac insufficiency which is mediated by the depressed intracellular calcium handling system in diabetic rat heart. Diabetes was produced in male rats 8 weeks after an injection of streptozotocin (60 mg/kg i.p.) and HSYA was administered (100 mg/kg) by gavage in the last 4 weeks. Hemodynamic and echocardiographic changes, cardiac calcium handling proteins, serum biochemistry, ET system and redox were measured. The compromised cardiac function in diabetic rats was accompanied by a significant down-regulation of the expression of RyR2, FKBP12.6 as well as SERCA2a and PLB. These were closely linked with oxidative stress, an increased ET-1 and up-regulation of ECE, PropreET-1 and iNOS mRNA in diabetic cardiomyopathy. After a 4 week treatment with HSYA, all abnormalities were reversed significantly. In conclusion, diabetic cardiomyopathy was correlated with an abnormal expression of calcium handing proteins in SR and an activated ET-ROS (reactive oxygen species) system in the diabetic affected myocardium. HSYA significantly improved the cardiac function and down-regulated the ET system and ROS pathway, resulting in a reversal of the abnormalities of expression of calcium handing proteins and the cardiac performance in diabetic cardiomyopathy. Copyright © 2008 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2468</identifier><identifier>PMID: 18570267</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Calcium Signaling - drug effects ; Calcium-Binding Proteins - metabolism ; Cardiomyopathies - drug therapy ; Cardiomyopathies - metabolism ; Cardiomyopathies - physiopathology ; Cardiotonic Agents - therapeutic use ; Chalcone - analogs & derivatives ; Chalcone - therapeutic use ; Diabetes Complications - drug therapy ; Diabetes Complications - metabolism ; Diabetes Complications - physiopathology ; Diabetes Mellitus, Experimental ; Disease Models, Animal ; Electrocardiography ; Gene Expression Regulation - drug effects ; General pharmacology ; Hemodynamics - drug effects ; Male ; Medical sciences ; Pharmacognosy. 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Drug treatments ; Pigments, Biological - therapeutic use ; Quinones - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species - metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism</subject><ispartof>Phytotherapy research, 2008-08, Vol.22 (8), p.1107-1114</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20557566$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18570267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Haibo</creatorcontrib><creatorcontrib>Liu, Qiuju</creatorcontrib><creatorcontrib>Shi, Mengqiong</creatorcontrib><creatorcontrib>Zeng, Xiaowei</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Wu, Limao</creatorcontrib><creatorcontrib>Li, Lianda</creatorcontrib><title>Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>Depressed sarcoplasmic reticulum (SR) Ca²⁺-ATPase (SERCA2a) and Ca²⁺-release channels (ryanodine receptor RyR2) are involved in diabetic cardiomyopathy, however, the implication of intracellular calcium handling proteins in SR is undefined. It was hypothesized that the down-regulation of the intracellular calcium handling proteins of SR is closely related to an up-regulated endothelin (ET) system. Hydroxysafflor yellow A (HSYA) is expected to ameliorate cardiac insufficiency which is mediated by the depressed intracellular calcium handling system in diabetic rat heart. Diabetes was produced in male rats 8 weeks after an injection of streptozotocin (60 mg/kg i.p.) and HSYA was administered (100 mg/kg) by gavage in the last 4 weeks. Hemodynamic and echocardiographic changes, cardiac calcium handling proteins, serum biochemistry, ET system and redox were measured. The compromised cardiac function in diabetic rats was accompanied by a significant down-regulation of the expression of RyR2, FKBP12.6 as well as SERCA2a and PLB. These were closely linked with oxidative stress, an increased ET-1 and up-regulation of ECE, PropreET-1 and iNOS mRNA in diabetic cardiomyopathy. After a 4 week treatment with HSYA, all abnormalities were reversed significantly. In conclusion, diabetic cardiomyopathy was correlated with an abnormal expression of calcium handing proteins in SR and an activated ET-ROS (reactive oxygen species) system in the diabetic affected myocardium. HSYA significantly improved the cardiac function and down-regulated the ET system and ROS pathway, resulting in a reversal of the abnormalities of expression of calcium handing proteins and the cardiac performance in diabetic cardiomyopathy. Copyright © 2008 John Wiley & Sons, Ltd.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium Signaling - drug effects</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>Cardiomyopathies - drug therapy</subject><subject>Cardiomyopathies - metabolism</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Cardiotonic Agents - therapeutic use</subject><subject>Chalcone - analogs & derivatives</subject><subject>Chalcone - therapeutic use</subject><subject>Diabetes Complications - drug therapy</subject><subject>Diabetes Complications - metabolism</subject><subject>Diabetes Complications - physiopathology</subject><subject>Diabetes Mellitus, Experimental</subject><subject>Disease Models, Animal</subject><subject>Electrocardiography</subject><subject>Gene Expression Regulation - drug effects</subject><subject>General pharmacology</subject><subject>Hemodynamics - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Pigments, Biological - therapeutic use</subject><subject>Quinones - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kctu1TAQhi1ERQ8FiScAb2CX1pfEiZfVETepEgtaiV008eUcIycOtlOat-wj4dADkiVbo2_-_x8PQm8ouaSEsKs5x0tWi-4Z2lEiZUWblj9HOyIbWtW0-3GOXqb0kxAiGalfoHPaNS1hot2hxz1E7cIcQzYqu3uDjbXllXCw-LjqGB7WBNb6EPFqvA-_8TUOE9YOBpOdwmrrB4XdlBZrnXJmUiuGnKMblmw0zgEvcxXNYfGQXWktwvlYfB7maFI6VdyUI6hiUKhYRL1yy4iPMGnvpgP-m69YbGiCqMLsIY3FPm4hFl9YN-EIOb1CZxZ8Mq9P9wW6-_Txdv-luvn2-ev--qayTPBcaSYEUDuIjhFrakJ4C-VvRDlKD8w03GjDQGhey06woWaybTutrLAUJFf8An140i3Rfi0m5X50aRsAJhOW1AvJJWnauoBvT-AyjEb3c3QjxLX_t4MCvD8BkMrgNsKkXPrPMdI0bSNE4d49cRZCD4dYmLvvjFC-rZWzmvM_32Wk_A</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>He, Haibo</creator><creator>Liu, Qiuju</creator><creator>Shi, Mengqiong</creator><creator>Zeng, Xiaowei</creator><creator>Yang, Jun</creator><creator>Wu, Limao</creator><creator>Li, Lianda</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats</title><author>He, Haibo ; Liu, Qiuju ; Shi, Mengqiong ; Zeng, Xiaowei ; Yang, Jun ; Wu, Limao ; Li, Lianda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f263t-d266a1fb6820fe40037a2046046cdb2e53ede2a6d349862b429778dcf6f1a93c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium Signaling - drug effects</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>Cardiomyopathies - drug therapy</topic><topic>Cardiomyopathies - metabolism</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Cardiotonic Agents - therapeutic use</topic><topic>Chalcone - analogs & derivatives</topic><topic>Chalcone - therapeutic use</topic><topic>Diabetes Complications - drug therapy</topic><topic>Diabetes Complications - metabolism</topic><topic>Diabetes Complications - physiopathology</topic><topic>Diabetes Mellitus, Experimental</topic><topic>Disease Models, Animal</topic><topic>Electrocardiography</topic><topic>Gene Expression Regulation - drug effects</topic><topic>General pharmacology</topic><topic>Hemodynamics - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Pigments, Biological - therapeutic use</topic><topic>Quinones - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Haibo</creatorcontrib><creatorcontrib>Liu, Qiuju</creatorcontrib><creatorcontrib>Shi, Mengqiong</creatorcontrib><creatorcontrib>Zeng, Xiaowei</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Wu, Limao</creatorcontrib><creatorcontrib>Li, Lianda</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Haibo</au><au>Liu, Qiuju</au><au>Shi, Mengqiong</au><au>Zeng, Xiaowei</au><au>Yang, Jun</au><au>Wu, Limao</au><au>Li, Lianda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>22</volume><issue>8</issue><spage>1107</spage><epage>1114</epage><pages>1107-1114</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Depressed sarcoplasmic reticulum (SR) Ca²⁺-ATPase (SERCA2a) and Ca²⁺-release channels (ryanodine receptor RyR2) are involved in diabetic cardiomyopathy, however, the implication of intracellular calcium handling proteins in SR is undefined. It was hypothesized that the down-regulation of the intracellular calcium handling proteins of SR is closely related to an up-regulated endothelin (ET) system. Hydroxysafflor yellow A (HSYA) is expected to ameliorate cardiac insufficiency which is mediated by the depressed intracellular calcium handling system in diabetic rat heart. Diabetes was produced in male rats 8 weeks after an injection of streptozotocin (60 mg/kg i.p.) and HSYA was administered (100 mg/kg) by gavage in the last 4 weeks. Hemodynamic and echocardiographic changes, cardiac calcium handling proteins, serum biochemistry, ET system and redox were measured. The compromised cardiac function in diabetic rats was accompanied by a significant down-regulation of the expression of RyR2, FKBP12.6 as well as SERCA2a and PLB. These were closely linked with oxidative stress, an increased ET-1 and up-regulation of ECE, PropreET-1 and iNOS mRNA in diabetic cardiomyopathy. After a 4 week treatment with HSYA, all abnormalities were reversed significantly. In conclusion, diabetic cardiomyopathy was correlated with an abnormal expression of calcium handing proteins in SR and an activated ET-ROS (reactive oxygen species) system in the diabetic affected myocardium. HSYA significantly improved the cardiac function and down-regulated the ET system and ROS pathway, resulting in a reversal of the abnormalities of expression of calcium handing proteins and the cardiac performance in diabetic cardiomyopathy. Copyright © 2008 John Wiley & Sons, Ltd.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>18570267</pmid><doi>10.1002/ptr.2468</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Oral Animals Biological and medical sciences Calcium Signaling - drug effects Calcium-Binding Proteins - metabolism Cardiomyopathies - drug therapy Cardiomyopathies - metabolism Cardiomyopathies - physiopathology Cardiotonic Agents - therapeutic use Chalcone - analogs & derivatives Chalcone - therapeutic use Diabetes Complications - drug therapy Diabetes Complications - metabolism Diabetes Complications - physiopathology Diabetes Mellitus, Experimental Disease Models, Animal Electrocardiography Gene Expression Regulation - drug effects General pharmacology Hemodynamics - drug effects Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Pigments, Biological - therapeutic use Quinones - therapeutic use Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism |
| title | Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats |
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