Differential properties of the optical-isomers of pranidipine, a 1,4-dihydropyridine calcium channel modulator

— Pranidipine is an optically‐active 1,4‐dihydropyridine (DHP) voltage‐dependent L‐type calcium channel inhibitor. Certain enantiomeric pairs display opposite effects, i.e., inhibition and activation of the calcium channel while others exhibit the same qualitative actions. We investigated pranidipin...

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Veröffentlicht in:	Fundamental & clinical pharmacology 1999-01, Vol.13 (6), p.650-655
Hauptverfasser:	Hirano, Takahiro, Mori, Toyoki, Kido, Masaru, Toide, Kiyotaka, Ohura, Makoto, Fujiki, Hiroyuki, Orito, Kensuke, Yoshida, Kenji, Ikezono, Katsumi, Sumida, Takumi, Nakayama, Natsuki, Yabuuchi, Youichi
Format:	Artikel
Sprache:	eng
Schlagworte:	anaesthetized rat Analysis of Variance Animals Antihypertensive agents Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Aorta Biological and medical sciences Blood Pressure - drug effects Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use calcium channel blocking action Cardiovascular system Dihydropyridines - pharmacology Dihydropyridines - therapeutic use Hypertension - drug therapy isolated aorta Male Medical sciences Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects optical-isomers Pharmacology. Drug treatments pranidipine Rats Rats, Inbred SHR Rats, Wistar spontaneously hypertensive rats Stereoisomerism Structure-Activity Relationship
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