The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients
AIMThe prevalence of occult hepatitis B virus (HBV) infection is relatively frequent among patients with immune suppression. The impairment of the immune system is well demonstrated in diabetics. We aimed to investigate the prevalence of occult HBV infection among hepatitis B core antibody (HbcAb)±...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2008-07, Vol.20 (7), p.668-673 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Demir, Mehmet Serin, Ender Göktürk, Savaş Ozturk, Nevin Akcaer Kulaksizoglu, Sevsen Ylmaz, Uğur |
| description | AIMThe prevalence of occult hepatitis B virus (HBV) infection is relatively frequent among patients with immune suppression. The impairment of the immune system is well demonstrated in diabetics. We aimed to investigate the prevalence of occult HBV infection among hepatitis B core antibody (HbcAb)± hepatitis B surface antibody (anti-HBs) positive type 2 diabetes mellitus patients.
MATERIALS AND METHODSThe study involved 100 HBcAb±anti-HBs type 2 diabetes mellitus patients and 100 age and sex matched, HBcAb±anti-HBs healthy blood donors. Exclusion criteria were positive serology for HBsAg, hepatitis C virus or HIV, diagnosis of malignancy or earlier organ transplantation history, use of immunosuppressive therapy. All patients were questioned about their past medical history and were tested for serum alanine aminotransferase and HBV DNA level.
RESULTSThe diabetic patients did not differ significantly from healthy controls in terms of sex and age. HBV DNA was detected in 11% of the diabetic patients (1×10–5×10 copies/ml) and in 3% of the controls (4×10–1×10 copies/ml). The difference between groups was statistically significant (P0.05). The serum alanine aminotransferase levels in diabetic patients were close to those of controls (26.2±16.4 IU/l vs. 23.9±9.7 IU/l; P>0.05).
CONCLUSIONThese data suggest that the prevalence of occult HBV infection is higher in diabetics compared with healthy controls and this may contribute to the increased prevalence of primary hepatocellular carcinoma in diabetics. |
| doi_str_mv | 10.1097/MEG.0b013e3282f55e1e |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69388941</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69388941</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4463-2610694f2ffeb2a3542c11493ec396e770b9e8ead43c849e7ce87da1867ba1b73</originalsourceid><addsrcrecordid>eNpdkMtuFDEQRS0EIkPgDxDyBnYdyo_2YwlRSJCC2AQJVpbbU9YYerob250of49HGSUSi1LV4txbVZeQtwzOGFj98dvF5RkMwAQKbnjse2T4jGyY1KLrldHPyQZsLztl2c8T8qqU3wBMC6ZfkhNmlLagYUN-3eyQLhlv_YhTQDpHOoewjpXucPE11VToZ3qb8lpomiKGmuapTbTeL0g53SY_YMVC9ziOqTbqoMKpltfkRfRjwTfHfkp-fLm4Ob_qrr9ffj3_dN0FKZXouGKgrIw8Rhy4F73kgTFpBQZhFWoNg0WDfitFMNKiDmj01h8-GDwbtDglHx58lzz_XbFUt08ltGv8hPNanLLCGCtZA-UDGPJcSsbolpz2Pt87Bu4QqWuRuv8jbbJ3R_912OP2SXTMsAHvj4AvwY8x-ymk8shxkNxaZZ72381jxVz-jOsdZrdDP9adA2icFrrjAKbZAnStmBD_AH0FkEo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69388941</pqid></control><display><type>article</type><title>The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Demir, Mehmet ; Serin, Ender ; Göktürk, Savaş ; Ozturk, Nevin Akcaer ; Kulaksizoglu, Sevsen ; Ylmaz, Uğur</creator><creatorcontrib>Demir, Mehmet ; Serin, Ender ; Göktürk, Savaş ; Ozturk, Nevin Akcaer ; Kulaksizoglu, Sevsen ; Ylmaz, Uğur</creatorcontrib><description>AIMThe prevalence of occult hepatitis B virus (HBV) infection is relatively frequent among patients with immune suppression. The impairment of the immune system is well demonstrated in diabetics. We aimed to investigate the prevalence of occult HBV infection among hepatitis B core antibody (HbcAb)± hepatitis B surface antibody (anti-HBs) positive type 2 diabetes mellitus patients.
MATERIALS AND METHODSThe study involved 100 HBcAb±anti-HBs type 2 diabetes mellitus patients and 100 age and sex matched, HBcAb±anti-HBs healthy blood donors. Exclusion criteria were positive serology for HBsAg, hepatitis C virus or HIV, diagnosis of malignancy or earlier organ transplantation history, use of immunosuppressive therapy. All patients were questioned about their past medical history and were tested for serum alanine aminotransferase and HBV DNA level.
RESULTSThe diabetic patients did not differ significantly from healthy controls in terms of sex and age. HBV DNA was detected in 11% of the diabetic patients (1×10–5×10 copies/ml) and in 3% of the controls (4×10–1×10 copies/ml). The difference between groups was statistically significant (P<0.05). The history of blood transfusion, surgery, and vaccination for HBV and alcohol use were similar in both groups (P>0.05). The serum alanine aminotransferase levels in diabetic patients were close to those of controls (26.2±16.4 IU/l vs. 23.9±9.7 IU/l; P>0.05).
CONCLUSIONThese data suggest that the prevalence of occult HBV infection is higher in diabetics compared with healthy controls and this may contribute to the increased prevalence of primary hepatocellular carcinoma in diabetics.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/MEG.0b013e3282f55e1e</identifier><identifier>PMID: 18679070</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Alanine Transaminase - blood ; Biological and medical sciences ; Blood Donors ; Carrier State - virology ; Case-Control Studies ; Diabetes Mellitus, Type 2 - complications ; Diabetes. Impaired glucose tolerance ; DNA, Viral - blood ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis B - complications ; Hepatitis B Antibodies - blood ; Hepatitis B Core Antigens - immunology ; Hepatitis B Surface Antigens - immunology ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Opportunistic Infections - complications ; Viral diseases ; Viral hepatitis</subject><ispartof>European journal of gastroenterology & hepatology, 2008-07, Vol.20 (7), p.668-673</ispartof><rights>2008 Lippincott Williams & Wilkins, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4463-2610694f2ffeb2a3542c11493ec396e770b9e8ead43c849e7ce87da1867ba1b73</citedby><cites>FETCH-LOGICAL-c4463-2610694f2ffeb2a3542c11493ec396e770b9e8ead43c849e7ce87da1867ba1b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20429968$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18679070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demir, Mehmet</creatorcontrib><creatorcontrib>Serin, Ender</creatorcontrib><creatorcontrib>Göktürk, Savaş</creatorcontrib><creatorcontrib>Ozturk, Nevin Akcaer</creatorcontrib><creatorcontrib>Kulaksizoglu, Sevsen</creatorcontrib><creatorcontrib>Ylmaz, Uğur</creatorcontrib><title>The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>AIMThe prevalence of occult hepatitis B virus (HBV) infection is relatively frequent among patients with immune suppression. The impairment of the immune system is well demonstrated in diabetics. We aimed to investigate the prevalence of occult HBV infection among hepatitis B core antibody (HbcAb)± hepatitis B surface antibody (anti-HBs) positive type 2 diabetes mellitus patients.
MATERIALS AND METHODSThe study involved 100 HBcAb±anti-HBs type 2 diabetes mellitus patients and 100 age and sex matched, HBcAb±anti-HBs healthy blood donors. Exclusion criteria were positive serology for HBsAg, hepatitis C virus or HIV, diagnosis of malignancy or earlier organ transplantation history, use of immunosuppressive therapy. All patients were questioned about their past medical history and were tested for serum alanine aminotransferase and HBV DNA level.
RESULTSThe diabetic patients did not differ significantly from healthy controls in terms of sex and age. HBV DNA was detected in 11% of the diabetic patients (1×10–5×10 copies/ml) and in 3% of the controls (4×10–1×10 copies/ml). The difference between groups was statistically significant (P<0.05). The history of blood transfusion, surgery, and vaccination for HBV and alcohol use were similar in both groups (P>0.05). The serum alanine aminotransferase levels in diabetic patients were close to those of controls (26.2±16.4 IU/l vs. 23.9±9.7 IU/l; P>0.05).
CONCLUSIONThese data suggest that the prevalence of occult HBV infection is higher in diabetics compared with healthy controls and this may contribute to the increased prevalence of primary hepatocellular carcinoma in diabetics.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Donors</subject><subject>Carrier State - virology</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>DNA, Viral - blood</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B Antibodies - blood</subject><subject>Hepatitis B Core Antigens - immunology</subject><subject>Hepatitis B Surface Antigens - immunology</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Opportunistic Infections - complications</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtuFDEQRS0EIkPgDxDyBnYdyo_2YwlRSJCC2AQJVpbbU9YYerob250of49HGSUSi1LV4txbVZeQtwzOGFj98dvF5RkMwAQKbnjse2T4jGyY1KLrldHPyQZsLztl2c8T8qqU3wBMC6ZfkhNmlLagYUN-3eyQLhlv_YhTQDpHOoewjpXucPE11VToZ3qb8lpomiKGmuapTbTeL0g53SY_YMVC9ziOqTbqoMKpltfkRfRjwTfHfkp-fLm4Ob_qrr9ffj3_dN0FKZXouGKgrIw8Rhy4F73kgTFpBQZhFWoNg0WDfitFMNKiDmj01h8-GDwbtDglHx58lzz_XbFUt08ltGv8hPNanLLCGCtZA-UDGPJcSsbolpz2Pt87Bu4QqWuRuv8jbbJ3R_912OP2SXTMsAHvj4AvwY8x-ymk8shxkNxaZZ72381jxVz-jOsdZrdDP9adA2icFrrjAKbZAnStmBD_AH0FkEo</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Demir, Mehmet</creator><creator>Serin, Ender</creator><creator>Göktürk, Savaş</creator><creator>Ozturk, Nevin Akcaer</creator><creator>Kulaksizoglu, Sevsen</creator><creator>Ylmaz, Uğur</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients</title><author>Demir, Mehmet ; Serin, Ender ; Göktürk, Savaş ; Ozturk, Nevin Akcaer ; Kulaksizoglu, Sevsen ; Ylmaz, Uğur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4463-2610694f2ffeb2a3542c11493ec396e770b9e8ead43c849e7ce87da1867ba1b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Biological and medical sciences</topic><topic>Blood Donors</topic><topic>Carrier State - virology</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>DNA, Viral - blood</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B Antibodies - blood</topic><topic>Hepatitis B Core Antigens - immunology</topic><topic>Hepatitis B Surface Antigens - immunology</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Opportunistic Infections - complications</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demir, Mehmet</creatorcontrib><creatorcontrib>Serin, Ender</creatorcontrib><creatorcontrib>Göktürk, Savaş</creatorcontrib><creatorcontrib>Ozturk, Nevin Akcaer</creatorcontrib><creatorcontrib>Kulaksizoglu, Sevsen</creatorcontrib><creatorcontrib>Ylmaz, Uğur</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demir, Mehmet</au><au>Serin, Ender</au><au>Göktürk, Savaş</au><au>Ozturk, Nevin Akcaer</au><au>Kulaksizoglu, Sevsen</au><au>Ylmaz, Uğur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2008-07</date><risdate>2008</risdate><volume>20</volume><issue>7</issue><spage>668</spage><epage>673</epage><pages>668-673</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>AIMThe prevalence of occult hepatitis B virus (HBV) infection is relatively frequent among patients with immune suppression. The impairment of the immune system is well demonstrated in diabetics. We aimed to investigate the prevalence of occult HBV infection among hepatitis B core antibody (HbcAb)± hepatitis B surface antibody (anti-HBs) positive type 2 diabetes mellitus patients.
MATERIALS AND METHODSThe study involved 100 HBcAb±anti-HBs type 2 diabetes mellitus patients and 100 age and sex matched, HBcAb±anti-HBs healthy blood donors. Exclusion criteria were positive serology for HBsAg, hepatitis C virus or HIV, diagnosis of malignancy or earlier organ transplantation history, use of immunosuppressive therapy. All patients were questioned about their past medical history and were tested for serum alanine aminotransferase and HBV DNA level.
RESULTSThe diabetic patients did not differ significantly from healthy controls in terms of sex and age. HBV DNA was detected in 11% of the diabetic patients (1×10–5×10 copies/ml) and in 3% of the controls (4×10–1×10 copies/ml). The difference between groups was statistically significant (P<0.05). The history of blood transfusion, surgery, and vaccination for HBV and alcohol use were similar in both groups (P>0.05). The serum alanine aminotransferase levels in diabetic patients were close to those of controls (26.2±16.4 IU/l vs. 23.9±9.7 IU/l; P>0.05).
CONCLUSIONThese data suggest that the prevalence of occult HBV infection is higher in diabetics compared with healthy controls and this may contribute to the increased prevalence of primary hepatocellular carcinoma in diabetics.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18679070</pmid><doi>10.1097/MEG.0b013e3282f55e1e</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Alanine Transaminase - blood Biological and medical sciences Blood Donors Carrier State - virology Case-Control Studies Diabetes Mellitus, Type 2 - complications Diabetes. Impaired glucose tolerance DNA, Viral - blood Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis B - complications Hepatitis B Antibodies - blood Hepatitis B Core Antigens - immunology Hepatitis B Surface Antigens - immunology Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Opportunistic Infections - complications Viral diseases Viral hepatitis |
| title | The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients |
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