Effects of matrix components on aromatase activity in breast stromal cells in culture

Local estradiol production within breast tissue is maintained by the aromatase cytochrome P450 arom complex, which has been localized primarily to the stromal component of tumors but also has been detected in the breast epithelial cells. Paracrine interactions between stromal and epithelial componen...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 1999-09, Vol.70 (4), p.249-256
Hauptverfasser:	Quinn, Anne L., Burak, William E., Brueggemeier, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Aromatase - metabolism Biological and medical sciences Breast - cytology Breast - drug effects Breast - enzymology Breast Neoplasms - enzymology Cell Division Cells, Cultured Collagen - pharmacology Dexamethasone - pharmacology Epithelial Cells - physiology Extracellular Matrix Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Humans Mother. Fetoplacental unit. Mammary gland. Milk Pregnancy. Parturition. Lactation RNA, Messenger - genetics Stromal Cells - drug effects Stromal Cells - enzymology Testosterone - pharmacology Thymidine - metabolism Tumor Cells, Cultured Vertebrates: reproduction Vimentin - genetics
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