A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis
ARF-mediated hydrolysis of GTP has been demonstrated to regulate coat disassembly of Golgi-derived COPI transport vesicles (Tanigawa, G., Orci, L., Amherdt, M., Ravazzola, M., Helms, J.B. and Rothman, J.E. (1993) J. Cell Biol. 123, 1365–1371). In addition, a requirement for GTP hydrolysis at an earl...
Gespeichert in:
| Veröffentlicht in: | FEBS letters 1999-12, Vol.462 (3), p.267-272 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 272 |
|---|---|
| container_issue | 3 |
| container_start_page | 267 |
| container_title | FEBS letters |
| container_volume | 462 |
| creator | Malsam, Jörg Gommel, Daniel Wieland, Felix T. Nickel, Walter |
| description | ARF-mediated hydrolysis of GTP has been demonstrated to regulate coat disassembly of Golgi-derived COPI transport vesicles (Tanigawa, G., Orci, L., Amherdt, M., Ravazzola, M., Helms, J.B. and Rothman, J.E. (1993) J. Cell Biol. 123, 1365–1371). In addition, a requirement for GTP hydrolysis at an early stage of COPI vesicle biogenesis has been established since cargo uptake is impaired in the presence of GTPγS (Nickel, W., Malsam, J., Gorgas, K., Ravazzola, M., Jenne, N., Helms, J.B. and Wieland, F.T. (1998) J. Cell Sci. 111, 3081–3090), a non-hydrolyzable analogue of GTP. We now demonstrate that the GTPase involved in the regulation of cargo uptake is ARF, revealing a multi-functional role of this GTPase in COPI-mediated vesicular transport. The molecular mechanism of cargo uptake as well as the functional implications of these findings on the overall process of COPI vesicle biogenesis are discussed. |
| doi_str_mv | 10.1016/S0014-5793(99)01543-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69388420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014579399015434</els_id><sourcerecordid>69388420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5254-163805621ab1e059de2e3d697429cbf9e62a0b90983917898f5a7197f8f0b1a23</originalsourceid><addsrcrecordid>eNqNkE1v1DAQhi1ERbeFnwDyCdFDij_y4TmhZdvSSpVaCThbjjNeDNl4ayet9t_j3VSIG5ysmXnmHesh5C1n55zx-uNXxnhZVA3IDwBnjFelLMoXZMFVIwtZ1uolWfxBjslJSj9ZrhWHV-SYs1qIhsGCrJc0hh6pC5EuL-5p9G1Iu96MPgzUGTvmvh_o-AOpDcOYWRoctSauA522o_mFtJuiH9Z0dXd_U9hgRuzoIyZvc2rrwxqHXKTX5MiZPuGb5_eUfL-6_La6Lm7vvtyslreFrURVFryWilW14KblyCroUKDsamhKAbZ1gLUwrAUGSgJvFChXmYZD45RjLTdCnpL3c-42hocJ06g3PlnsezNgmJKuQSpVCpbBagZtDClFdHob_cbEneZM7w3rg2G916cB9MGwLvPeu-cDU7vB7q-tWWkGrmfgyfe4-79UfXX5WRwm-wHAob2_9WmOwmzs0WPUyXocLHY-oh11F_w_fvsbX46d2Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69388420</pqid></control><display><type>article</type><title>A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Alma/SFX Local Collection</source><creator>Malsam, Jörg ; Gommel, Daniel ; Wieland, Felix T. ; Nickel, Walter</creator><creatorcontrib>Malsam, Jörg ; Gommel, Daniel ; Wieland, Felix T. ; Nickel, Walter</creatorcontrib><description>ARF-mediated hydrolysis of GTP has been demonstrated to regulate coat disassembly of Golgi-derived COPI transport vesicles (Tanigawa, G., Orci, L., Amherdt, M., Ravazzola, M., Helms, J.B. and Rothman, J.E. (1993) J. Cell Biol. 123, 1365–1371). In addition, a requirement for GTP hydrolysis at an early stage of COPI vesicle biogenesis has been established since cargo uptake is impaired in the presence of GTPγS (Nickel, W., Malsam, J., Gorgas, K., Ravazzola, M., Jenne, N., Helms, J.B. and Wieland, F.T. (1998) J. Cell Sci. 111, 3081–3090), a non-hydrolyzable analogue of GTP. We now demonstrate that the GTPase involved in the regulation of cargo uptake is ARF, revealing a multi-functional role of this GTPase in COPI-mediated vesicular transport. The molecular mechanism of cargo uptake as well as the functional implications of these findings on the overall process of COPI vesicle biogenesis are discussed.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(99)01543-4</identifier><identifier>PMID: 10622709</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>ADP ribosylation factor ; ADP-Ribosylation Factors - physiology ; Animals ; Cargo ; Cell Line ; CHO Cells ; Coat Protein Complex I - metabolism ; Coated Vesicles - metabolism ; Coatomer ; COPI-coated vesicle ; Cricetinae ; Golgi ; Golgi Apparatus - metabolism ; Guanosine 5'-O-(3-Thiotriphosphate) - metabolism ; Hydrolysis ; Intracellular Membranes - metabolism ; Mutation ; Vesicular transport</subject><ispartof>FEBS letters, 1999-12, Vol.462 (3), p.267-272</ispartof><rights>1999 Federation of European Biochemical Societies</rights><rights>FEBS Letters 462 (1999) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5254-163805621ab1e059de2e3d697429cbf9e62a0b90983917898f5a7197f8f0b1a23</citedby><cites>FETCH-LOGICAL-c5254-163805621ab1e059de2e3d697429cbf9e62a0b90983917898f5a7197f8f0b1a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0014-5793%2899%2901543-4$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-5793(99)01543-4$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,1412,1428,3537,27905,27906,45555,45556,45976,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10622709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malsam, Jörg</creatorcontrib><creatorcontrib>Gommel, Daniel</creatorcontrib><creatorcontrib>Wieland, Felix T.</creatorcontrib><creatorcontrib>Nickel, Walter</creatorcontrib><title>A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>ARF-mediated hydrolysis of GTP has been demonstrated to regulate coat disassembly of Golgi-derived COPI transport vesicles (Tanigawa, G., Orci, L., Amherdt, M., Ravazzola, M., Helms, J.B. and Rothman, J.E. (1993) J. Cell Biol. 123, 1365–1371). In addition, a requirement for GTP hydrolysis at an early stage of COPI vesicle biogenesis has been established since cargo uptake is impaired in the presence of GTPγS (Nickel, W., Malsam, J., Gorgas, K., Ravazzola, M., Jenne, N., Helms, J.B. and Wieland, F.T. (1998) J. Cell Sci. 111, 3081–3090), a non-hydrolyzable analogue of GTP. We now demonstrate that the GTPase involved in the regulation of cargo uptake is ARF, revealing a multi-functional role of this GTPase in COPI-mediated vesicular transport. The molecular mechanism of cargo uptake as well as the functional implications of these findings on the overall process of COPI vesicle biogenesis are discussed.</description><subject>ADP ribosylation factor</subject><subject>ADP-Ribosylation Factors - physiology</subject><subject>Animals</subject><subject>Cargo</subject><subject>Cell Line</subject><subject>CHO Cells</subject><subject>Coat Protein Complex I - metabolism</subject><subject>Coated Vesicles - metabolism</subject><subject>Coatomer</subject><subject>COPI-coated vesicle</subject><subject>Cricetinae</subject><subject>Golgi</subject><subject>Golgi Apparatus - metabolism</subject><subject>Guanosine 5'-O-(3-Thiotriphosphate) - metabolism</subject><subject>Hydrolysis</subject><subject>Intracellular Membranes - metabolism</subject><subject>Mutation</subject><subject>Vesicular transport</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi1ERbeFnwDyCdFDij_y4TmhZdvSSpVaCThbjjNeDNl4ayet9t_j3VSIG5ysmXnmHesh5C1n55zx-uNXxnhZVA3IDwBnjFelLMoXZMFVIwtZ1uolWfxBjslJSj9ZrhWHV-SYs1qIhsGCrJc0hh6pC5EuL-5p9G1Iu96MPgzUGTvmvh_o-AOpDcOYWRoctSauA522o_mFtJuiH9Z0dXd_U9hgRuzoIyZvc2rrwxqHXKTX5MiZPuGb5_eUfL-6_La6Lm7vvtyslreFrURVFryWilW14KblyCroUKDsamhKAbZ1gLUwrAUGSgJvFChXmYZD45RjLTdCnpL3c-42hocJ06g3PlnsezNgmJKuQSpVCpbBagZtDClFdHob_cbEneZM7w3rg2G916cB9MGwLvPeu-cDU7vB7q-tWWkGrmfgyfe4-79UfXX5WRwm-wHAob2_9WmOwmzs0WPUyXocLHY-oh11F_w_fvsbX46d2Q</recordid><startdate>19991203</startdate><enddate>19991203</enddate><creator>Malsam, Jörg</creator><creator>Gommel, Daniel</creator><creator>Wieland, Felix T.</creator><creator>Nickel, Walter</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991203</creationdate><title>A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis</title><author>Malsam, Jörg ; Gommel, Daniel ; Wieland, Felix T. ; Nickel, Walter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5254-163805621ab1e059de2e3d697429cbf9e62a0b90983917898f5a7197f8f0b1a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>ADP ribosylation factor</topic><topic>ADP-Ribosylation Factors - physiology</topic><topic>Animals</topic><topic>Cargo</topic><topic>Cell Line</topic><topic>CHO Cells</topic><topic>Coat Protein Complex I - metabolism</topic><topic>Coated Vesicles - metabolism</topic><topic>Coatomer</topic><topic>COPI-coated vesicle</topic><topic>Cricetinae</topic><topic>Golgi</topic><topic>Golgi Apparatus - metabolism</topic><topic>Guanosine 5'-O-(3-Thiotriphosphate) - metabolism</topic><topic>Hydrolysis</topic><topic>Intracellular Membranes - metabolism</topic><topic>Mutation</topic><topic>Vesicular transport</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malsam, Jörg</creatorcontrib><creatorcontrib>Gommel, Daniel</creatorcontrib><creatorcontrib>Wieland, Felix T.</creatorcontrib><creatorcontrib>Nickel, Walter</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malsam, Jörg</au><au>Gommel, Daniel</au><au>Wieland, Felix T.</au><au>Nickel, Walter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1999-12-03</date><risdate>1999</risdate><volume>462</volume><issue>3</issue><spage>267</spage><epage>272</epage><pages>267-272</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>ARF-mediated hydrolysis of GTP has been demonstrated to regulate coat disassembly of Golgi-derived COPI transport vesicles (Tanigawa, G., Orci, L., Amherdt, M., Ravazzola, M., Helms, J.B. and Rothman, J.E. (1993) J. Cell Biol. 123, 1365–1371). In addition, a requirement for GTP hydrolysis at an early stage of COPI vesicle biogenesis has been established since cargo uptake is impaired in the presence of GTPγS (Nickel, W., Malsam, J., Gorgas, K., Ravazzola, M., Jenne, N., Helms, J.B. and Wieland, F.T. (1998) J. Cell Sci. 111, 3081–3090), a non-hydrolyzable analogue of GTP. We now demonstrate that the GTPase involved in the regulation of cargo uptake is ARF, revealing a multi-functional role of this GTPase in COPI-mediated vesicular transport. The molecular mechanism of cargo uptake as well as the functional implications of these findings on the overall process of COPI vesicle biogenesis are discussed.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>10622709</pmid><doi>10.1016/S0014-5793(99)01543-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1999-12, Vol.462 (3), p.267-272 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69388420 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | ADP ribosylation factor ADP-Ribosylation Factors - physiology Animals Cargo Cell Line CHO Cells Coat Protein Complex I - metabolism Coated Vesicles - metabolism Coatomer COPI-coated vesicle Cricetinae Golgi Golgi Apparatus - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Hydrolysis Intracellular Membranes - metabolism Mutation Vesicular transport |
| title | A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T12%3A07%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20role%20for%20ADP%20ribosylation%20factor%20in%20the%20control%20of%20cargo%20uptake%20during%20COPI-coated%20vesicle%20biogenesis&rft.jtitle=FEBS%20letters&rft.au=Malsam,%20J%C3%B6rg&rft.date=1999-12-03&rft.volume=462&rft.issue=3&rft.spage=267&rft.epage=272&rft.pages=267-272&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1016/S0014-5793(99)01543-4&rft_dat=%3Cproquest_cross%3E69388420%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69388420&rft_id=info:pmid/10622709&rft_els_id=S0014579399015434&rfr_iscdi=true |