Microwave generated solid dispersions containing Ibuprofen
The purpose of this study was to apply the attractive technique of the microwaves irradiation (MW) for the preparation of solvent-free solid dispersions (SD). In particular, the microwave technology has been considered in order to prepare an enhanced release dosage form for the poorly soluble drug I...
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| Veröffentlicht in: | International journal of pharmaceutics 2008-09, Vol.361 (1), p.125-130 |
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| container_title | International journal of pharmaceutics |
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| creator | Moneghini, Mariarosa Bellich, Barbara Baxa, Pietro Princivalle, Francesco |
| description | The purpose of this study was to apply the attractive technique of the microwaves irradiation (MW) for the preparation of solvent-free solid dispersions (SD). In particular, the microwave technology has been considered in order to prepare an enhanced release dosage form for the poorly soluble drug Ibuprofen (IBU), employing PVP/VA 60/40 (PVP/VA 64) and hydroxypropyl-β-cyclodextrin (HP-β-CD) as hydrophilic carriers. Their physico-chemical characteristics and dissolution properties were compared to the corresponding physical mixtures and the drug alone. The results of physico-chemical characterization attested a correspondence of the solid state of the drug before and after irradiation treatment and that an amorphous form of the drug was obtained. This result, together with the presence of the hydrophilic polymers determined a remarkable enhancement of the in vitro dissolution rate of the drug suggesting that the microwave technique could be considered as a new and interesting method to prepare drug–polymer systems. |
| doi_str_mv | 10.1016/j.ijpharm.2008.05.026 |
| format | Article |
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In particular, the microwave technology has been considered in order to prepare an enhanced release dosage form for the poorly soluble drug Ibuprofen (IBU), employing PVP/VA 60/40 (PVP/VA 64) and hydroxypropyl-β-cyclodextrin (HP-β-CD) as hydrophilic carriers. Their physico-chemical characteristics and dissolution properties were compared to the corresponding physical mixtures and the drug alone. The results of physico-chemical characterization attested a correspondence of the solid state of the drug before and after irradiation treatment and that an amorphous form of the drug was obtained. 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Drug treatments ; Physico-chemical characterization ; PVP/VA 60/40 ; Pyrrolidines - chemistry ; Solid dispersions ; Solubility ; Technology, Pharmaceutical - methods ; Vinyl Compounds - chemistry</subject><ispartof>International journal of pharmaceutics, 2008-09, Vol.361 (1), p.125-130</ispartof><rights>2008 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-4da5c16ae2f337d7ca65a50fe691fc376c8ecfac2ab2522ce1e7a1da42547c13</citedby><cites>FETCH-LOGICAL-c459t-4da5c16ae2f337d7ca65a50fe691fc376c8ecfac2ab2522ce1e7a1da42547c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2008.05.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20589234$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18573321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moneghini, Mariarosa</creatorcontrib><creatorcontrib>Bellich, Barbara</creatorcontrib><creatorcontrib>Baxa, Pietro</creatorcontrib><creatorcontrib>Princivalle, Francesco</creatorcontrib><title>Microwave generated solid dispersions containing Ibuprofen</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>The purpose of this study was to apply the attractive technique of the microwaves irradiation (MW) for the preparation of solvent-free solid dispersions (SD). In particular, the microwave technology has been considered in order to prepare an enhanced release dosage form for the poorly soluble drug Ibuprofen (IBU), employing PVP/VA 60/40 (PVP/VA 64) and hydroxypropyl-β-cyclodextrin (HP-β-CD) as hydrophilic carriers. Their physico-chemical characteristics and dissolution properties were compared to the corresponding physical mixtures and the drug alone. The results of physico-chemical characterization attested a correspondence of the solid state of the drug before and after irradiation treatment and that an amorphous form of the drug was obtained. This result, together with the presence of the hydrophilic polymers determined a remarkable enhancement of the in vitro dissolution rate of the drug suggesting that the microwave technique could be considered as a new and interesting method to prepare drug–polymer systems.</description><subject>2-Hydroxypropyl-beta-cyclodextrin</subject><subject>beta-Cyclodextrins - chemistry</subject><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical</subject><subject>Dosage Forms</subject><subject>Drug Carriers - chemistry</subject><subject>General pharmacology</subject><subject>Hydroxypropyl-β-cyclodextrin</subject><subject>Ibuprofen</subject><subject>Ibuprofen - chemistry</subject><subject>Medical sciences</subject><subject>Microwaves</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physico-chemical characterization</subject><subject>PVP/VA 60/40</subject><subject>Pyrrolidines - chemistry</subject><subject>Solid dispersions</subject><subject>Solubility</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Vinyl Compounds - chemistry</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1v2zAQhokiQeOk_QkNtKSbVH6IpNwlCIw2NZAgS3bifDylNGRKIWUX-feVYaEZO93y3L3vPYx9EbwSXJhv2ypsh9-QdpXkvKm4rrg0H9hCNFaVqrbmjC24sk2phVUX7DLnLefcSKE-sgvRaKuUFAv2_TFg6v_AgYoXipRgJF_kvgu-8CEPlHLoYy6wjyOEGOJLsd7sh9S3FD-x8xa6TJ_necWef_54Xv0qH57u16u7hxJrvRzL2oNGYYBkq5T1FsFo0LwlsxQtKmuwIWwBJWyklhJJkAXhoZa6tijUFft6Ojulvu4pj24XMlLXQaR-n51Zqsaoup5AfQKnh3JO1LohhR2kNye4OzpzWzc7c0dnjms3OZv2rueA_WZH_n1rljQBNzMAGaFrE0QM-R8nuW6WUh0L3J44mmwcAiWXMVBE8iERjs734T9V_gJ5yY4N</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Moneghini, Mariarosa</creator><creator>Bellich, Barbara</creator><creator>Baxa, Pietro</creator><creator>Princivalle, Francesco</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Microwave generated solid dispersions containing Ibuprofen</title><author>Moneghini, Mariarosa ; Bellich, Barbara ; Baxa, Pietro ; Princivalle, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-4da5c16ae2f337d7ca65a50fe691fc376c8ecfac2ab2522ce1e7a1da42547c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>2-Hydroxypropyl-beta-cyclodextrin</topic><topic>beta-Cyclodextrins - chemistry</topic><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical</topic><topic>Dosage Forms</topic><topic>Drug Carriers - chemistry</topic><topic>General pharmacology</topic><topic>Hydroxypropyl-β-cyclodextrin</topic><topic>Ibuprofen</topic><topic>Ibuprofen - chemistry</topic><topic>Medical sciences</topic><topic>Microwaves</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physico-chemical characterization</topic><topic>PVP/VA 60/40</topic><topic>Pyrrolidines - chemistry</topic><topic>Solid dispersions</topic><topic>Solubility</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Vinyl Compounds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moneghini, Mariarosa</creatorcontrib><creatorcontrib>Bellich, Barbara</creatorcontrib><creatorcontrib>Baxa, Pietro</creatorcontrib><creatorcontrib>Princivalle, Francesco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moneghini, Mariarosa</au><au>Bellich, Barbara</au><au>Baxa, Pietro</au><au>Princivalle, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microwave generated solid dispersions containing Ibuprofen</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>361</volume><issue>1</issue><spage>125</spage><epage>130</epage><pages>125-130</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>The purpose of this study was to apply the attractive technique of the microwaves irradiation (MW) for the preparation of solvent-free solid dispersions (SD). In particular, the microwave technology has been considered in order to prepare an enhanced release dosage form for the poorly soluble drug Ibuprofen (IBU), employing PVP/VA 60/40 (PVP/VA 64) and hydroxypropyl-β-cyclodextrin (HP-β-CD) as hydrophilic carriers. Their physico-chemical characteristics and dissolution properties were compared to the corresponding physical mixtures and the drug alone. The results of physico-chemical characterization attested a correspondence of the solid state of the drug before and after irradiation treatment and that an amorphous form of the drug was obtained. This result, together with the presence of the hydrophilic polymers determined a remarkable enhancement of the in vitro dissolution rate of the drug suggesting that the microwave technique could be considered as a new and interesting method to prepare drug–polymer systems.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18573321</pmid><doi>10.1016/j.ijpharm.2008.05.026</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2008-09, Vol.361 (1), p.125-130 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 2-Hydroxypropyl-beta-cyclodextrin beta-Cyclodextrins - chemistry Biological and medical sciences Chemistry, Pharmaceutical Dosage Forms Drug Carriers - chemistry General pharmacology Hydroxypropyl-β-cyclodextrin Ibuprofen Ibuprofen - chemistry Medical sciences Microwaves Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physico-chemical characterization PVP/VA 60/40 Pyrrolidines - chemistry Solid dispersions Solubility Technology, Pharmaceutical - methods Vinyl Compounds - chemistry |
| title | Microwave generated solid dispersions containing Ibuprofen |
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