Elongation and Desaturation of Fatty Acids are Critical in Growth, Lipid Metabolism and Ontogeny of Caenorhabditis elegans

Recently, it was reported that a deficit in the mouse stearoyl-CoA desaturase 1 gene decreases biosynthesis and accumulation of fatty acid and revitalizes the β-oxidation of fatty acid. To examine the physiological role of fatty acid desaturase (FAT) and elongase (ELO)-gene transduction in ontogeny,...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2008-08, Vol.144 (2), p.149-158
Hauptverfasser:	Horikawa, Makoto, Nomura, Toshihisa, Hashimoto, Teppei, Sakamoto, Kazuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - antagonists & inhibitors Acetyltransferases - genetics Acetyltransferases - physiology Adiposity - genetics Animals Caenorhabditis elegans - embryology Caenorhabditis elegans - enzymology Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins - antagonists & inhibitors Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Caenorhabditis elegans Proteins - physiology fatty acid desaturase Fatty Acid Desaturases - antagonists & inhibitors Fatty Acid Desaturases - genetics Fatty Acid Desaturases - physiology fatty acid elongase Fatty Acids - metabolism Forkhead Transcription Factors lifespan Lipid Metabolism Longevity Mutation ontogeny Reproduction RNA Interference Transcription Factors - metabolism
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