Pharmacological interference of vascular smooth muscle cell hypertrophy induced by glycosylated human oxyhaemoglobin

Nonenzymatically glycosylated human oxyhaemoglobin induces vascular smooth muscle cell hypertrophy by releasing reactive oxygen species. We analysed the ability of drugs with antihypertrophic properties for the vascular wall and/or antioxidant activity, such as captopril, losartan, and nifedipine, o...

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Veröffentlicht in:	European journal of pharmacology 1999-12, Vol.386 (2), p.317-321
Hauptverfasser:	Peiró, Concepción, Vallejo, Susana, Nevado, Julián, Angulo, Javier, Llergo, José L, Cercas, Elena, Rodrı́guez-Mañas, Leocadio, Sánchez-Ferrer, Carlos F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacology Antioxidants - pharmacology Biological and medical sciences Cardiovascular system cell Cells, Cultured Diabetes glycosylated Glycosylation Humans Hypertrophy Hypertrophy - chemically induced Hypoglycemic Agents - pharmacology Medical sciences Miscellaneous Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Oxidative stress Oxyhaemoglobin Oxyhemoglobins - adverse effects Oxyhemoglobins - antagonists & inhibitors Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Smooth muscle vascular
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