The transporter associated with antigen processing TAP: structure and function
The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T-lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the...
Gespeichert in:
| Veröffentlicht in: | FEBS Letters 1999-12, Vol.464 (3), p.108-112 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 112 |
|---|---|
| container_issue | 3 |
| container_start_page | 108 |
| container_title | FEBS Letters |
| container_volume | 464 |
| creator | Lankat-Buttgereit, Brigitte Tampé, Robert |
| description | The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T-lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the membrane of the ER. Efficient assembly of MHC-peptide complex requires the formation of a macromolecular transport and chaperone complex composed of TAP, tapasin and MHC class I molecules. Therefore, structure and function of TAP is important for the understanding of the immune surveillance. |
| doi_str_mv | 10.1016/S0014-5793(99)01676-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69384238</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014579399016762</els_id><sourcerecordid>69384238</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4782-3e100ca9f415cd77bfb3344929540647b164455928560eaab92605db31332c1b3</originalsourceid><addsrcrecordid>eNqNkMtOwzAQRS0EoqXwCaCsECwCfsWx2aCCeEkIkChry3EmrVGbFNsB8fekDULsYGV55syd0UFon-ATgok4fcaY8DTLFTtS6rir5CKlG2hIZM5SxoXcRMMfZIB2QnjF3V8StY0GBAsiucyH6GEygyR6U4dl4yP4xITQWGcilMmHi7PE1NFNoU6WvrEQgqunyWT8dJaE6FsbWw8dUSZVW9vomnoXbVVmHmDv-x2hl-uryeVtev94c3c5vk8tzyVNGRCMrVEVJ5kt87yoCsY4V1RlHAueF0RwnmWKykxgMKZQVOCsLBhhjFpSsBE67HO7s95aCFEvXLAwn5samjZooZjklMkOzHrQ-iYED5Veercw_lMTrFci9VqkXlnSSum1SE27uYPvBW2xgPLXVG-uA2574MPN4fN_qfr66oKuO6uGUuvyatd5HwWdsXcHXgfroLZQOg826rJxf1z7BVBQlc4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69384238</pqid></control><display><type>article</type><title>The transporter associated with antigen processing TAP: structure and function</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Lankat-Buttgereit, Brigitte ; Tampé, Robert</creator><creatorcontrib>Lankat-Buttgereit, Brigitte ; Tampé, Robert</creatorcontrib><description>The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T-lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the membrane of the ER. Efficient assembly of MHC-peptide complex requires the formation of a macromolecular transport and chaperone complex composed of TAP, tapasin and MHC class I molecules. Therefore, structure and function of TAP is important for the understanding of the immune surveillance.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(99)01676-2</identifier><identifier>PMID: 10618487</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>ABC transporter ; ABC, ATP-binding cassette ; Antigen presentation ; Antigens - metabolism ; Carrier Proteins - chemistry ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; CTL, cytotoxic T-lymphocytes ; Disease ; Endoplasmic Reticulum - metabolism ; ER, endoplasmic reticulum ; Gene Expression Regulation ; Humans ; MHC, major histocompatibility complex ; NBD, nucleotide-binding domain ; Structure-Activity Relationship ; Substrate Specificity ; TAP, transporter associated with antigen processing ; TMD, transmembrane domain ; Transport mechanism ; Virus persistence</subject><ispartof>FEBS Letters, 1999-12, Vol.464 (3), p.108-112</ispartof><rights>1999 Federation of European Biochemical Societies</rights><rights>FEBS Letters 464 (1999) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4782-3e100ca9f415cd77bfb3344929540647b164455928560eaab92605db31332c1b3</citedby><cites>FETCH-LOGICAL-c4782-3e100ca9f415cd77bfb3344929540647b164455928560eaab92605db31332c1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0014-5793%2899%2901676-2$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-5793(99)01676-2$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>313,314,780,784,792,1416,1432,3548,27920,27922,27923,45572,45573,45993,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10618487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lankat-Buttgereit, Brigitte</creatorcontrib><creatorcontrib>Tampé, Robert</creatorcontrib><title>The transporter associated with antigen processing TAP: structure and function</title><title>FEBS Letters</title><addtitle>FEBS Lett</addtitle><description>The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T-lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the membrane of the ER. Efficient assembly of MHC-peptide complex requires the formation of a macromolecular transport and chaperone complex composed of TAP, tapasin and MHC class I molecules. Therefore, structure and function of TAP is important for the understanding of the immune surveillance.</description><subject>ABC transporter</subject><subject>ABC, ATP-binding cassette</subject><subject>Antigen presentation</subject><subject>Antigens - metabolism</subject><subject>Carrier Proteins - chemistry</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>CTL, cytotoxic T-lymphocytes</subject><subject>Disease</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>ER, endoplasmic reticulum</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>MHC, major histocompatibility complex</subject><subject>NBD, nucleotide-binding domain</subject><subject>Structure-Activity Relationship</subject><subject>Substrate Specificity</subject><subject>TAP, transporter associated with antigen processing</subject><subject>TMD, transmembrane domain</subject><subject>Transport mechanism</subject><subject>Virus persistence</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EoqXwCaCsECwCfsWx2aCCeEkIkChry3EmrVGbFNsB8fekDULsYGV55syd0UFon-ATgok4fcaY8DTLFTtS6rir5CKlG2hIZM5SxoXcRMMfZIB2QnjF3V8StY0GBAsiucyH6GEygyR6U4dl4yP4xITQWGcilMmHi7PE1NFNoU6WvrEQgqunyWT8dJaE6FsbWw8dUSZVW9vomnoXbVVmHmDv-x2hl-uryeVtev94c3c5vk8tzyVNGRCMrVEVJ5kt87yoCsY4V1RlHAueF0RwnmWKykxgMKZQVOCsLBhhjFpSsBE67HO7s95aCFEvXLAwn5samjZooZjklMkOzHrQ-iYED5Veercw_lMTrFci9VqkXlnSSum1SE27uYPvBW2xgPLXVG-uA2574MPN4fN_qfr66oKuO6uGUuvyatd5HwWdsXcHXgfroLZQOg826rJxf1z7BVBQlc4</recordid><startdate>19991231</startdate><enddate>19991231</enddate><creator>Lankat-Buttgereit, Brigitte</creator><creator>Tampé, Robert</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991231</creationdate><title>The transporter associated with antigen processing TAP: structure and function</title><author>Lankat-Buttgereit, Brigitte ; Tampé, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4782-3e100ca9f415cd77bfb3344929540647b164455928560eaab92605db31332c1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>ABC transporter</topic><topic>ABC, ATP-binding cassette</topic><topic>Antigen presentation</topic><topic>Antigens - metabolism</topic><topic>Carrier Proteins - chemistry</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>CTL, cytotoxic T-lymphocytes</topic><topic>Disease</topic><topic>Endoplasmic Reticulum - metabolism</topic><topic>ER, endoplasmic reticulum</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>MHC, major histocompatibility complex</topic><topic>NBD, nucleotide-binding domain</topic><topic>Structure-Activity Relationship</topic><topic>Substrate Specificity</topic><topic>TAP, transporter associated with antigen processing</topic><topic>TMD, transmembrane domain</topic><topic>Transport mechanism</topic><topic>Virus persistence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lankat-Buttgereit, Brigitte</creatorcontrib><creatorcontrib>Tampé, Robert</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS Letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lankat-Buttgereit, Brigitte</au><au>Tampé, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The transporter associated with antigen processing TAP: structure and function</atitle><jtitle>FEBS Letters</jtitle><addtitle>FEBS Lett</addtitle><date>1999-12-31</date><risdate>1999</risdate><volume>464</volume><issue>3</issue><spage>108</spage><epage>112</epage><pages>108-112</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T-lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the membrane of the ER. Efficient assembly of MHC-peptide complex requires the formation of a macromolecular transport and chaperone complex composed of TAP, tapasin and MHC class I molecules. Therefore, structure and function of TAP is important for the understanding of the immune surveillance.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>10618487</pmid><doi>10.1016/S0014-5793(99)01676-2</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS Letters, 1999-12, Vol.464 (3), p.108-112 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69384238 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | ABC transporter ABC, ATP-binding cassette Antigen presentation Antigens - metabolism Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism CTL, cytotoxic T-lymphocytes Disease Endoplasmic Reticulum - metabolism ER, endoplasmic reticulum Gene Expression Regulation Humans MHC, major histocompatibility complex NBD, nucleotide-binding domain Structure-Activity Relationship Substrate Specificity TAP, transporter associated with antigen processing TMD, transmembrane domain Transport mechanism Virus persistence |
| title | The transporter associated with antigen processing TAP: structure and function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T04%3A46%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20transporter%20associated%20with%20antigen%20processing%20TAP:%20structure%20and%20function&rft.jtitle=FEBS%20Letters&rft.au=Lankat-Buttgereit,%20Brigitte&rft.date=1999-12-31&rft.volume=464&rft.issue=3&rft.spage=108&rft.epage=112&rft.pages=108-112&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1016/S0014-5793(99)01676-2&rft_dat=%3Cproquest_cross%3E69384238%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69384238&rft_id=info:pmid/10618487&rft_els_id=S0014579399016762&rfr_iscdi=true |