Vitamin D receptor levels in colorectal cancer Possible role of BsmI polymorphism
A high expression of vitamin D receptor (VDR) in colorectal cancer (CRC) tumoral tissue has been related to a good prognosis and it has been proposed that it could be a good biological marker of CRC progression. Nevertheless, there are no previous studies that compare the VDR expression in tumoral t...
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| Veröffentlicht in: | The Journal of steroid biochemistry and molecular biology 2008-07, Vol.111 (1-2), p.87-90 |
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| container_title | The Journal of steroid biochemistry and molecular biology |
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| creator | PARISI, Eva RENE, Josep Maria CARDUS, Anna VALCHEVA, Petya PINOL-FELIS, Carme VALDIVIELSO, José Manuel FERNANDEZ, Elvira |
| description | A high expression of vitamin D receptor (VDR) in colorectal cancer (CRC) tumoral tissue has been related to a good prognosis and it has been proposed that it could be a good biological marker of CRC progression. Nevertheless, there are no previous studies that compare the VDR expression in tumoral towards normal tissue of the same CRC patient in relation to VDR BsmI genotype. We collected normal and tumoral tissue samples, as well as blood samples, from CRC patients (n=170) and controls (n=122). VDR genotyping was performed and BsmI homozygous patients were selected (CRC=50, Cont=32). VDR mRNA and protein levels were analyzed. We also measured 25-Hydroxyvitamin D serum levels. We found no differences in the polymorphism distribution in tumoral versus normal tissue (control: BB=15.7%, bb=41.3%, Bb=43%; CRC: BB=14.2%, bb=41.9%, Bb=43.9%). Furthermore, VDR levels decreased in colonic cancer tissue (mean: 3.03) versus normal mucosa (11.62) from the same patient (p |
| doi_str_mv | 10.1016/j.jsbmb.2008.05.001 |
| format | Article |
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Nevertheless, there are no previous studies that compare the VDR expression in tumoral towards normal tissue of the same CRC patient in relation to VDR BsmI genotype. We collected normal and tumoral tissue samples, as well as blood samples, from CRC patients (n=170) and controls (n=122). VDR genotyping was performed and BsmI homozygous patients were selected (CRC=50, Cont=32). VDR mRNA and protein levels were analyzed. We also measured 25-Hydroxyvitamin D serum levels. We found no differences in the polymorphism distribution in tumoral versus normal tissue (control: BB=15.7%, bb=41.3%, Bb=43%; CRC: BB=14.2%, bb=41.9%, Bb=43.9%). Furthermore, VDR levels decreased in colonic cancer tissue (mean: 3.03) versus normal mucosa (11.62) from the same patient (p<0.001), but this decrease was similar in both genotypes. There were differences in 25-Hydroxyvitamin D(3) levels between the CRC and the control group (CRC=8.65 ng/ml, Cont=18.15 ng/ml). In conclusion, we found a decrease in VDR levels in tumoral compared with normal mucosa from the same patient. This difference is independent of the BsmI polymorphism.</description><identifier>ISSN: 0960-0760</identifier><identifier>EISSN: 1879-1220</identifier><identifier>DOI: 10.1016/j.jsbmb.2008.05.001</identifier><identifier>PMID: 18583126</identifier><language>eng</language><publisher>Oxford: Elsevier Science</publisher><subject>Biological and medical sciences ; Case-Control Studies ; Colorectal Neoplasms - genetics ; Gastroenterology. Liver. Pancreas. Abdomen ; Genotype ; Homozygote ; Humans ; Medical sciences ; Polymorphism, Genetic ; Receptors, Calcitriol - genetics ; Receptors, Calcitriol - metabolism ; Retrospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>The Journal of steroid biochemistry and molecular biology, 2008-07, Vol.111 (1-2), p.87-90</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20572984$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18583126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PARISI, Eva</creatorcontrib><creatorcontrib>RENE, Josep Maria</creatorcontrib><creatorcontrib>CARDUS, Anna</creatorcontrib><creatorcontrib>VALCHEVA, Petya</creatorcontrib><creatorcontrib>PINOL-FELIS, Carme</creatorcontrib><creatorcontrib>VALDIVIELSO, José Manuel</creatorcontrib><creatorcontrib>FERNANDEZ, Elvira</creatorcontrib><title>Vitamin D receptor levels in colorectal cancer Possible role of BsmI polymorphism</title><title>The Journal of steroid biochemistry and molecular biology</title><addtitle>J Steroid Biochem Mol Biol</addtitle><description>A high expression of vitamin D receptor (VDR) in colorectal cancer (CRC) tumoral tissue has been related to a good prognosis and it has been proposed that it could be a good biological marker of CRC progression. Nevertheless, there are no previous studies that compare the VDR expression in tumoral towards normal tissue of the same CRC patient in relation to VDR BsmI genotype. We collected normal and tumoral tissue samples, as well as blood samples, from CRC patients (n=170) and controls (n=122). VDR genotyping was performed and BsmI homozygous patients were selected (CRC=50, Cont=32). VDR mRNA and protein levels were analyzed. We also measured 25-Hydroxyvitamin D serum levels. We found no differences in the polymorphism distribution in tumoral versus normal tissue (control: BB=15.7%, bb=41.3%, Bb=43%; CRC: BB=14.2%, bb=41.9%, Bb=43.9%). Furthermore, VDR levels decreased in colonic cancer tissue (mean: 3.03) versus normal mucosa (11.62) from the same patient (p<0.001), but this decrease was similar in both genotypes. There were differences in 25-Hydroxyvitamin D(3) levels between the CRC and the control group (CRC=8.65 ng/ml, Cont=18.15 ng/ml). In conclusion, we found a decrease in VDR levels in tumoral compared with normal mucosa from the same patient. This difference is independent of the BsmI polymorphism.</description><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genotype</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Receptors, Calcitriol - metabolism</subject><subject>Retrospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0960-0760</issn><issn>1879-1220</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9LAzEQxYMotlY_gSC56G3XSbJJdo9a_xUKKqjXJUmzuCVp1mQr9NsbsHp583jzY2AeQucESgJEXK_LddJelxSgLoGXAOQATUktm4JQCodoCo2AAqSACTpJaQ0AjBF5jCak5jUjVEzR60c_Kt9v8B2O1thhDBE7-21dwjk0wYUcj8phozbGRvwSUuq1sziGLKHDt8kv8BDczoc4fPbJn6KjTrlkz_Zzht4f7t_mT8Xy-XExv1kWA2XNWLCOcaWJshpWnQRrueZCcqgIF2IlVFXXvGoaC5IZmxckG04FcGL0qqsYm6Gr37tDDF9bm8bW98lY59TGhm1qRcNqKqXM4MUe3GpvV-0Qe6_irv0rIQOXe0Alo1wX86t9-ucocEmbumI_Su9sMg</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>PARISI, Eva</creator><creator>RENE, Josep Maria</creator><creator>CARDUS, Anna</creator><creator>VALCHEVA, Petya</creator><creator>PINOL-FELIS, Carme</creator><creator>VALDIVIELSO, José Manuel</creator><creator>FERNANDEZ, Elvira</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Vitamin D receptor levels in colorectal cancer Possible role of BsmI polymorphism</title><author>PARISI, Eva ; RENE, Josep Maria ; CARDUS, Anna ; VALCHEVA, Petya ; PINOL-FELIS, Carme ; VALDIVIELSO, José Manuel ; FERNANDEZ, Elvira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-3f35ab1aeb0df70ee5b5675041566d6a4885499e073ce6751073526051cbdf433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genotype</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Receptors, Calcitriol - metabolism</topic><topic>Retrospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PARISI, Eva</creatorcontrib><creatorcontrib>RENE, Josep Maria</creatorcontrib><creatorcontrib>CARDUS, Anna</creatorcontrib><creatorcontrib>VALCHEVA, Petya</creatorcontrib><creatorcontrib>PINOL-FELIS, Carme</creatorcontrib><creatorcontrib>VALDIVIELSO, José Manuel</creatorcontrib><creatorcontrib>FERNANDEZ, Elvira</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PARISI, Eva</au><au>RENE, Josep Maria</au><au>CARDUS, Anna</au><au>VALCHEVA, Petya</au><au>PINOL-FELIS, Carme</au><au>VALDIVIELSO, José Manuel</au><au>FERNANDEZ, Elvira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D receptor levels in colorectal cancer Possible role of BsmI polymorphism</atitle><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle><addtitle>J Steroid Biochem Mol Biol</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>111</volume><issue>1-2</issue><spage>87</spage><epage>90</epage><pages>87-90</pages><issn>0960-0760</issn><eissn>1879-1220</eissn><abstract>A high expression of vitamin D receptor (VDR) in colorectal cancer (CRC) tumoral tissue has been related to a good prognosis and it has been proposed that it could be a good biological marker of CRC progression. Nevertheless, there are no previous studies that compare the VDR expression in tumoral towards normal tissue of the same CRC patient in relation to VDR BsmI genotype. We collected normal and tumoral tissue samples, as well as blood samples, from CRC patients (n=170) and controls (n=122). VDR genotyping was performed and BsmI homozygous patients were selected (CRC=50, Cont=32). VDR mRNA and protein levels were analyzed. We also measured 25-Hydroxyvitamin D serum levels. We found no differences in the polymorphism distribution in tumoral versus normal tissue (control: BB=15.7%, bb=41.3%, Bb=43%; CRC: BB=14.2%, bb=41.9%, Bb=43.9%). Furthermore, VDR levels decreased in colonic cancer tissue (mean: 3.03) versus normal mucosa (11.62) from the same patient (p<0.001), but this decrease was similar in both genotypes. There were differences in 25-Hydroxyvitamin D(3) levels between the CRC and the control group (CRC=8.65 ng/ml, Cont=18.15 ng/ml). In conclusion, we found a decrease in VDR levels in tumoral compared with normal mucosa from the same patient. This difference is independent of the BsmI polymorphism.</abstract><cop>Oxford</cop><pub>Elsevier Science</pub><pmid>18583126</pmid><doi>10.1016/j.jsbmb.2008.05.001</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences Case-Control Studies Colorectal Neoplasms - genetics Gastroenterology. Liver. Pancreas. Abdomen Genotype Homozygote Humans Medical sciences Polymorphism, Genetic Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Retrospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Vitamin D receptor levels in colorectal cancer Possible role of BsmI polymorphism |
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