Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats

Chronic elevations in interleukin (IL)-6 have been associated with insulin resistance, but acute IL-6 administration can enhance insulin sensitivity. Our aim was to exogenously administer IL-6 to rats to elicit either chronic or repeated acute elevations in systemic IL-6. We hypothesized that a cont...

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Veröffentlicht in:	Journal of endocrinology 2008-08, Vol.198 (2), p.367-374
Hauptverfasser:	Holmes, Anna G, Mesa, Jose L, Neill, Bronwyn A, Chung, Jason, Carey, Andrew L, Steinberg, Gregory R, Kemp, Bruce E, Southgate, Robert J, Lancaster, Graeme I, Bruce, Clinton R, Watt, Matthew J, Febbraio, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Blood Glucose - drug effects Enzyme-Linked Immunosorbent Assay Gene Expression Regulation - drug effects Glucose Tolerance Test Immunoblotting Insulin Resistance - physiology Interleukin-6 - pharmacology Ion Channels - metabolism Male Mitochondrial Proteins - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Phosphorylation - drug effects PPAR alpha - metabolism Rats Rats, Wistar Uncoupling Protein 2 Uncoupling Protein 3
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