The CB1 Endocannabinoid System Modulates Adipocyte Insulin Sensitivity

Mounting evidence suggests that the endocannabinoid system regulates energy metabolism through direct effects on peripheral tissues as well as central effects that regulate appetite. Here we examined the effect of cannabinoid receptor 1 (CB1) signaling on insulin action in fat cells. We examined eff...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2008-08, Vol.16 (8), p.1727-1734
Hauptverfasser:	Motaghedi, Roja, McGraw, Timothy E.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Animals Antibodies Arachidonic Acids - pharmacology Body fat Cannabinoid Receptor Modulators - pharmacology Cell Membrane - metabolism Dose-Response Relationship, Drug Drug dosages Endocannabinoids Glucose Transporter Type 4 - metabolism Glycerides - pharmacology Insulin - physiology Insulin Resistance Kinases Medical research Metabolism Mice Obesity Pertussis Toxin - pharmacology Phosphorylation Piperidines - pharmacology Proto-Oncogene Proteins c-akt - metabolism Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - metabolism Receptor, Insulin - metabolism Weight control
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