Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide
The purpose of this study was to prepare excipient-free porous microparticles of bendroflumethiazide by spray drying and to characterise the physicochemical properties of the particles produced. Solutions of bendroflumethiazide in ethanol/water, ethanol/water/ammonium carbonate or methanol/water/amm...
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| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2008-08, Vol.69 (3), p.1182-1186 |
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| container_title | European journal of pharmaceutics and biopharmaceutics |
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| creator | Healy, A.M. McDonald, B.F. Tajber, L. Corrigan, O.I. |
| description | The purpose of this study was to prepare excipient-free porous microparticles of bendroflumethiazide by spray drying and to characterise the physicochemical properties of the particles produced. Solutions of bendroflumethiazide in ethanol/water, ethanol/water/ammonium carbonate or methanol/water/ammonium carbonate were spray dried using a laboratory spray dryer. Spray dried products were characterised by scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, FTIR, laser diffraction particle sizing and density measurement. Nanoporous microparticles (NPMPs) were prepared from the alcoholic solutions containing ammonium carbonate. NPMPs were amorphous in nature, had median particles sizes less than 3
μm and densities that were significantly reduced compared to non-porous spray dried bendroflumethiazide powder. The novel process may be used to produce excipient-free amorphous microparticles with desirable physical properties such as amorphous solid state, porosity and low bulk density. This new engineering technology has applications in the design of other therapeutic agents such as those used in pulmonary delivery. |
| doi_str_mv | 10.1016/j.ejpb.2008.04.020 |
| format | Article |
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μm and densities that were significantly reduced compared to non-porous spray dried bendroflumethiazide powder. The novel process may be used to produce excipient-free amorphous microparticles with desirable physical properties such as amorphous solid state, porosity and low bulk density. This new engineering technology has applications in the design of other therapeutic agents such as those used in pulmonary delivery.</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2008.04.020</identifier><identifier>PMID: 18595674</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amorphous ; Antihypertensive Agents - administration & dosage ; Antihypertensive Agents - chemistry ; Bendroflumethiazide - administration & dosage ; Bendroflumethiazide - chemistry ; Biological and medical sciences ; Desiccation ; Excipient-free ; General pharmacology ; Medical sciences ; Microscopy, Electron, Scanning ; Nanoparticles ; Nanopores ; Nebulizers and Vaporizers ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Porous microparticles ; Powders ; Spectroscopy, Fourier Transform Infrared ; Spray drying ; Surface-Active Agents ; X-Ray Diffraction</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2008-08, Vol.69 (3), p.1182-1186</ispartof><rights>2008 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c299t-5732ed251e139f915c9b00496bbe5ec8cab4df42021221ca4670da6fa25f263a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939641108001628$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20593554$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18595674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Healy, A.M.</creatorcontrib><creatorcontrib>McDonald, B.F.</creatorcontrib><creatorcontrib>Tajber, L.</creatorcontrib><creatorcontrib>Corrigan, O.I.</creatorcontrib><title>Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide</title><title>European journal of pharmaceutics and biopharmaceutics</title><addtitle>Eur J Pharm Biopharm</addtitle><description>The purpose of this study was to prepare excipient-free porous microparticles of bendroflumethiazide by spray drying and to characterise the physicochemical properties of the particles produced. Solutions of bendroflumethiazide in ethanol/water, ethanol/water/ammonium carbonate or methanol/water/ammonium carbonate were spray dried using a laboratory spray dryer. Spray dried products were characterised by scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, FTIR, laser diffraction particle sizing and density measurement. Nanoporous microparticles (NPMPs) were prepared from the alcoholic solutions containing ammonium carbonate. NPMPs were amorphous in nature, had median particles sizes less than 3
μm and densities that were significantly reduced compared to non-porous spray dried bendroflumethiazide powder. The novel process may be used to produce excipient-free amorphous microparticles with desirable physical properties such as amorphous solid state, porosity and low bulk density. This new engineering technology has applications in the design of other therapeutic agents such as those used in pulmonary delivery.</description><subject>Amorphous</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Antihypertensive Agents - chemistry</subject><subject>Bendroflumethiazide - administration & dosage</subject><subject>Bendroflumethiazide - chemistry</subject><subject>Biological and medical sciences</subject><subject>Desiccation</subject><subject>Excipient-free</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Nanoparticles</subject><subject>Nanopores</subject><subject>Nebulizers and Vaporizers</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Porous microparticles</subject><subject>Powders</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Spray drying</subject><subject>Surface-Active Agents</subject><subject>X-Ray Diffraction</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAURS1URKeFP9BFlU0RLBL8mcQSGzSigFRoF7BiYb04z6pHSZzaGQT8-jqaUdmxeptzr-47hFwwWjHK6ne7CndzV3FK24rKinL6jGxY24hSSMlOyIZqoctaMnZKzlLaUUplo9oX5JS1Squ6kRvyc3sPEeyC0SdYfJiK4Ar8bf3scVpKFxGLCaYwhxj2qRi9jWGGuHg7YCrefLv7epferpkOpz4GN-xHXO49_PU9viTPHQwJXx3vOflx_fH79nN5c_vpy_bDTWm51kupGsGx54ohE9pppqzu8lJddx0qtK2FTvZOcsoZ58yCrBvaQ-2AK8drAeKcvD70zjE87DEtZvTJ4jDAhHm0qbVomdQ8g_wA5idSiujMHP0I8Y9h1KxKzc6sSs2q1FBpstIcujy277sR-3-Ro8MMXB0BSBYGF2GyPj1xnCotlFq59wcOs4tfHqNJNku22PuIdjF98P_b8QihT5W2</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Healy, A.M.</creator><creator>McDonald, B.F.</creator><creator>Tajber, L.</creator><creator>Corrigan, O.I.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200808</creationdate><title>Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide</title><author>Healy, A.M. ; McDonald, B.F. ; Tajber, L. ; Corrigan, O.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-5732ed251e139f915c9b00496bbe5ec8cab4df42021221ca4670da6fa25f263a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Amorphous</topic><topic>Antihypertensive Agents - administration & dosage</topic><topic>Antihypertensive Agents - chemistry</topic><topic>Bendroflumethiazide - administration & dosage</topic><topic>Bendroflumethiazide - chemistry</topic><topic>Biological and medical sciences</topic><topic>Desiccation</topic><topic>Excipient-free</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Nanoparticles</topic><topic>Nanopores</topic><topic>Nebulizers and Vaporizers</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Porous microparticles</topic><topic>Powders</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Spray drying</topic><topic>Surface-Active Agents</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Healy, A.M.</creatorcontrib><creatorcontrib>McDonald, B.F.</creatorcontrib><creatorcontrib>Tajber, L.</creatorcontrib><creatorcontrib>Corrigan, O.I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Healy, A.M.</au><au>McDonald, B.F.</au><au>Tajber, L.</au><au>Corrigan, O.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2008-08</date><risdate>2008</risdate><volume>69</volume><issue>3</issue><spage>1182</spage><epage>1186</epage><pages>1182-1186</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>The purpose of this study was to prepare excipient-free porous microparticles of bendroflumethiazide by spray drying and to characterise the physicochemical properties of the particles produced. Solutions of bendroflumethiazide in ethanol/water, ethanol/water/ammonium carbonate or methanol/water/ammonium carbonate were spray dried using a laboratory spray dryer. Spray dried products were characterised by scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, FTIR, laser diffraction particle sizing and density measurement. Nanoporous microparticles (NPMPs) were prepared from the alcoholic solutions containing ammonium carbonate. NPMPs were amorphous in nature, had median particles sizes less than 3
μm and densities that were significantly reduced compared to non-porous spray dried bendroflumethiazide powder. The novel process may be used to produce excipient-free amorphous microparticles with desirable physical properties such as amorphous solid state, porosity and low bulk density. This new engineering technology has applications in the design of other therapeutic agents such as those used in pulmonary delivery.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18595674</pmid><doi>10.1016/j.ejpb.2008.04.020</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of pharmaceutics and biopharmaceutics, 2008-08, Vol.69 (3), p.1182-1186 |
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| subjects | Amorphous Antihypertensive Agents - administration & dosage Antihypertensive Agents - chemistry Bendroflumethiazide - administration & dosage Bendroflumethiazide - chemistry Biological and medical sciences Desiccation Excipient-free General pharmacology Medical sciences Microscopy, Electron, Scanning Nanoparticles Nanopores Nebulizers and Vaporizers Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Porous microparticles Powders Spectroscopy, Fourier Transform Infrared Spray drying Surface-Active Agents X-Ray Diffraction |
| title | Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide |
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