Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

We quantified the amount of amyloid beta-peptide (Abeta) immunoreactivity as well as amyloid deposits in a large cohort of transgenic mice overexpressing the V717F human amyloid precursor protein (APP(V717F+/-) TG mice) with no, one, or two mouse apolipoprotein E (Apoe) alleles at various ages. Rema...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-12, Vol.96 (26), p.15233-15238
Hauptverfasser:	Bales, K R, Verina, T, Cummins, D J, Du, Y, Dodel, R C, Saura, J, Fishman, C E, DeLong, C A, Piccardo, P, Petegnief, V, Ghetti, B, Paul, S M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - pathology Amyloid - isolation & purification Amyloid - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Apolipoproteins E - genetics Apolipoproteins E - isolation & purification Apolipoproteins E - metabolism Brain - pathology Cerebral Cortex - pathology Disease Models, Animal Gliosis Heterozygote Hippocampus - pathology Homozygote Mice Mice, Knockout Mice, Transgenic Neuroglia - metabolism
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