17Beta-estradiol mobilizes bone marrow-derived endothelial progenitor cells to tumors

Neovascularization is critical for tumor growth and development. The cellular mediators for this process are yet to be defined. We discovered that bone marrow-derived endothelial progenitor cells (BM-EPC), having the phenotype (CD133+, CD34+, VEGFR-2+), initiate neovascularization in response to TG1...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-08, Vol.68 (15), p.6038-6042
Hauptverfasser:	Suriano, Robert, Chaudhuri, Devyani, Johnson, Raja Singh, Lambers, Erin, Ashok, Badithe T, Kishore, Raj, Tiwari, Raj K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Estradiol - pharmacology Female Fluorescent Dyes Matrix Metalloproteinases - genetics Mice Neoplasms, Experimental - blood supply Neovascularization, Pathologic Ovariectomy
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