COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells

The p16/pocket-protein pathway sets a balance between tumor suppression and capacity for tissue regeneration. Understanding the upstream signaling pathway that turns on the expression of p16 is required both for knowing the tumorigenic stresses from which this pathway provides protection and for app...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-08, Vol.68 (15), p.6049-6053
Hauptverfasser:	Mroz, Edmund A, Baird, Abigail H, Michaud, William A, Rocco, James W
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Cellular Senescence - genetics Chromatin Immunoprecipitation Fibroblasts - metabolism Gene Expression Regulation Genes, p16 Humans Keratinocytes - metabolism Polymerase Chain Reaction Protein Binding RNA, Messenger - genetics
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