Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in microglia

Excessive nitric oxide (NO) production by activated microglia plays a critical role in neurodegenerative disorders. In this study, we found that 9-(2-chlorobenyl)-9 H-carbazole-3-carbaldehyde (LCY-2-CHO) suppressed the NO production in lipopolysaccharide (LPS)/interferon-γ (IFNγ)-stimulated murine m...

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Veröffentlicht in:	Biochemical pharmacology 2008-08, Vol.76 (4), p.507-519
Hauptverfasser:	Chang, Ling-Chu, Tsao, Lo-Ti, Chang, Chi-Sen, Chen, Chun-Jung, Huang, Li-Jiau, Kuo, Sheng-Chu, Lin, Ruey-Hseng, Wang, Jih-Pyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein-1 Animals Anti-Inflammatory Agents - pharmacology Biological and medical sciences Carbazoles - pharmacology CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors CCAAT/enhancer-binding protein Cells, Cultured Inducible nitric oxide synthase Interferon-gamma - adverse effects LCY-2-CHO Lipopolysaccharides - adverse effects Medical sciences Mice Microglia - drug effects Microglia - metabolism Microglia - pathology Microglial cells Nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - genetics Nuclear Proteins - drug effects Pharmacology. Drug treatments Rats RNA, Messenger - drug effects Transcription Factor AP-1 - antagonists & inhibitors
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