Ketamine inhibits agonist-induced cAMP accumulation increase in human airway smooth muscle cells

Cyclic 3',5' adenosine monophosphate (cAMP) is a second messenger of the beta adrenergic receptor (betaAR). Ketamine causes an increase in the intracellular accumulation of cAMP in several non-human tissue preparations. A "species effect" may explain the differing results of keta...

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Veröffentlicht in:	Canadian journal of anesthesia 1999-12, Vol.46 (12), p.1172-1177
Hauptverfasser:	HILL, G. E, ANDERSON, J. L, WHITTEN, C. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - drug effects Adenylyl Cyclases - metabolism Adrenergic beta-Agonists - pharmacology Anesthetics, Dissociative - pharmacology Anesthetics. Neuromuscular blocking agents Biological and medical sciences Cell Line Cells Colforsin - pharmacology Cyclic AMP - agonists Cyclic AMP - metabolism Humans Isoproterenol - pharmacology Ketamine - pharmacology Medical sciences Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscular system Neuropharmacology Pharmacology. Drug treatments Trachea - cytology Trachea - drug effects
Online-Zugang:	Volltext
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