Effect of PEG Crystallization on the Self-Assembly of PEG/Peptide Copolymers Containing Amyloid Peptide Fragments

The effect of poly(ethylene glycol) PEG crystallization on β-sheet fibril formation is studied for a series of three peptide/PEG conjugates containing fragments modified from the amyloid β peptide, specifically KLVFF, FFKLVFF, and AAKLVFF. These are conjugated to PEG with M n = 3300 g mol−1. It is f...

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Veröffentlicht in:	Langmuir 2008-08, Vol.24 (15), p.8210-8214
Hauptverfasser:	Hamley, Ian W, Krysmann, Marta J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloid - chemistry Amyloid - ultrastructure Chemistry Chromatography, High Pressure Liquid Colloidal state and disperse state Crystallization Exact sciences and technology General and physical chemistry Materials: Nano-and Mesostructured Materials, Polymers, Gels, Liquid Crystals, Composites Microscopy, Atomic Force Peptide Fragments - chemistry Peptide Fragments - ultrastructure Polyethylene Glycols - chemistry Protein Structure, Secondary Spectroscopy, Fourier Transform Infrared Surface physical chemistry X-Ray Diffraction
Online-Zugang:	Volltext
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