Incidence and predictors of virologic failure of antiretroviral triple-drug therapy in a community-based cohort

Highly active antiretroviral therapy fails to reach its recommended goal of sustained suppression of viral replication in a substantial proportion of patients. We analyzed incidence and predictors of virologic failure of the first regimen of a triple-drug combination therapy, including a protease in...

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Veröffentlicht in:	AIDS research and human retroviruses 1999-12, Vol.15 (18), p.1631-1638
Hauptverfasser:	PARIS, D, LEDERGERBER, B, WEBER, R, JOST, J, FLEPP, M, OPRAVIL, M, RUEF, C, ZIMMERLI, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AIDS/HIV Anti-HIV Agents - administration & dosage Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CD4 Lymphocyte Count Cohort Studies Didanosine - administration & dosage Didanosine - therapeutic use Disease Progression Drug Administration Schedule Drug Resistance, Microbial Drug Therapy, Combination Female HIV Infections - drug therapy HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects HIV-1 - isolation & purification Human immunodeficiency virus 1 Humans Incidence Indinavir - administration & dosage Indinavir - therapeutic use Lamivudine - administration & dosage Lamivudine - therapeutic use Male Medical sciences Middle Aged nucleoside analogs Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - therapeutic use Risk Factors Ritonavir - administration & dosage Ritonavir - therapeutic use RNA, Viral - blood Salvage Therapy Saquinavir - administration & dosage Saquinavir - therapeutic use Stavudine - administration & dosage Stavudine - therapeutic use Switzerland Treatment Failure triple therapy Viral Load Zalcitabine - administration & dosage Zalcitabine - therapeutic use Zidovudine - administration & dosage Zidovudine - therapeutic use
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