Host species-specific usage of the TLR4-LPS receptor complex

Recognition of LPS depends on the interaction of at least three molecules forming the LPS-receptor complex. The most important ones, CD14, MD2 and Toll-like receptor (TLR) 4 share a high degree of homology between species. In the present study, we investigated the importance of species-specific rest...

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Veröffentlicht in:	Innate immunity (London, England) England), 2008-08, Vol.14 (4), p.223-231
Hauptverfasser:	Lizundia, Regina, Sauter, Kay-Sara, Taylor, Geraldine, Werling, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Cell Line Enzyme Activation - drug effects Enzyme Activation - genetics Humans Immunity, Innate - genetics Interleukin-8 - agonists Interleukin-8 - metabolism Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - immunology Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Lymphocyte Antigen 96 - agonists Lymphocyte Antigen 96 - genetics Lymphocyte Antigen 96 - immunology Mice Multiprotein Complexes - genetics Multiprotein Complexes - immunology NF-kappaB-Inducing Kinase Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - immunology Respiratory syncytial virus Respiratory Syncytial Viruses Signal Transduction - drug effects Signal Transduction - immunology Species Specificity Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - chemistry Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology Transfection Transgenes
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