Distribution of heme oxygenase 2 in nerves and c-kit(+) interstitial cells in human stomach
Different populations of interstitial cells (ICs) may serve as gut pacemakers or as intermediaries between enteric nerves and smooth muscle cells. However, very little is known about the substances that ICs might use to communicate with other cells and no data are available in humans. Because carbon...
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| Veröffentlicht in: | Histochemistry and cell biology 1999-10, Vol.112 (4), p.317-322 |
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| creator | Porcher, C Orsoni, P Berdah, S Monges, G Mazet, B |
| description | Different populations of interstitial cells (ICs) may serve as gut pacemakers or as intermediaries between enteric nerves and smooth muscle cells. However, very little is known about the substances that ICs might use to communicate with other cells and no data are available in humans. Because carbon monoxide (CO) is emerging as a putative mediator in the regulation of gastrointestinal motility, this study examined the presence of heme oxygenase (HO2), the constitutive form of the enzyme for CO production, in human stomach with particular attention to ICs. The distribution of HO2 in nerves and ICs in human antrum was studied using specific antibodies. The immunostaining was observed using confocal laser scanning microscopy. HO2 immunoreactivity was found in myenteric neurons and nerve fibers supplying the circular muscle layer and in intramuscular c-kit(+) ICs, but not in c-kit(+) ICs surrounding the myenteric ganglia. The presence of HO2 in different cell types suggests that CO may serve as an intercellular messenger between myenteric neurons and ICs and between ICs and smooth muscle cells in human stomach. |
| doi_str_mv | 10.1007/s004180050453 |
| format | Article |
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However, very little is known about the substances that ICs might use to communicate with other cells and no data are available in humans. Because carbon monoxide (CO) is emerging as a putative mediator in the regulation of gastrointestinal motility, this study examined the presence of heme oxygenase (HO2), the constitutive form of the enzyme for CO production, in human stomach with particular attention to ICs. The distribution of HO2 in nerves and ICs in human antrum was studied using specific antibodies. The immunostaining was observed using confocal laser scanning microscopy. HO2 immunoreactivity was found in myenteric neurons and nerve fibers supplying the circular muscle layer and in intramuscular c-kit(+) ICs, but not in c-kit(+) ICs surrounding the myenteric ganglia. The presence of HO2 in different cell types suggests that CO may serve as an intercellular messenger between myenteric neurons and ICs and between ICs and smooth muscle cells in human stomach.</description><identifier>ISSN: 0948-6143</identifier><identifier>EISSN: 1432-119X</identifier><identifier>DOI: 10.1007/s004180050453</identifier><identifier>PMID: 10550617</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; c-Kit protein ; Carbon monoxide ; Cell Communication ; Confocal microscopy ; Enteric nervous system ; Female ; Fluorescent Antibody Technique, Indirect ; Ganglia ; Gastric motility ; Heme ; Heme Oxygenase (Decyclizing) - metabolism ; Humans ; Immunoreactivity ; Interstitial cells ; Male ; Middle Aged ; Muscle, Smooth - innervation ; Myenteric plexus ; Myenteric Plexus - cytology ; Myenteric Plexus - enzymology ; Nerve Fibers - enzymology ; Nerves ; Neurons - enzymology ; Oxygenase ; Pacemakers ; Proto-Oncogene Proteins c-kit - metabolism ; Pyloric Antrum - cytology ; Pyloric Antrum - enzymology ; Pyloric Antrum - innervation ; Smooth muscle ; Stomach</subject><ispartof>Histochemistry and cell biology, 1999-10, Vol.112 (4), p.317-322</ispartof><rights>Springer-Verlag Berlin Heidelberg 1999.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-277d238534d7d967b5449af132197ea40a34d613b8bf0821a6acbf406587ff783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10550617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Porcher, C</creatorcontrib><creatorcontrib>Orsoni, P</creatorcontrib><creatorcontrib>Berdah, S</creatorcontrib><creatorcontrib>Monges, G</creatorcontrib><creatorcontrib>Mazet, B</creatorcontrib><title>Distribution of heme oxygenase 2 in nerves and c-kit(+) interstitial cells in human stomach</title><title>Histochemistry and cell biology</title><addtitle>Histochem Cell Biol</addtitle><description>Different populations of interstitial cells (ICs) may serve as gut pacemakers or as intermediaries between enteric nerves and smooth muscle cells. However, very little is known about the substances that ICs might use to communicate with other cells and no data are available in humans. Because carbon monoxide (CO) is emerging as a putative mediator in the regulation of gastrointestinal motility, this study examined the presence of heme oxygenase (HO2), the constitutive form of the enzyme for CO production, in human stomach with particular attention to ICs. The distribution of HO2 in nerves and ICs in human antrum was studied using specific antibodies. The immunostaining was observed using confocal laser scanning microscopy. HO2 immunoreactivity was found in myenteric neurons and nerve fibers supplying the circular muscle layer and in intramuscular c-kit(+) ICs, but not in c-kit(+) ICs surrounding the myenteric ganglia. The presence of HO2 in different cell types suggests that CO may serve as an intercellular messenger between myenteric neurons and ICs and between ICs and smooth muscle cells in human stomach.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>c-Kit protein</subject><subject>Carbon monoxide</subject><subject>Cell Communication</subject><subject>Confocal microscopy</subject><subject>Enteric nervous system</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Ganglia</subject><subject>Gastric motility</subject><subject>Heme</subject><subject>Heme Oxygenase (Decyclizing) - metabolism</subject><subject>Humans</subject><subject>Immunoreactivity</subject><subject>Interstitial cells</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Smooth - innervation</subject><subject>Myenteric plexus</subject><subject>Myenteric Plexus - cytology</subject><subject>Myenteric Plexus - enzymology</subject><subject>Nerve Fibers - enzymology</subject><subject>Nerves</subject><subject>Neurons - enzymology</subject><subject>Oxygenase</subject><subject>Pacemakers</subject><subject>Proto-Oncogene Proteins c-kit - metabolism</subject><subject>Pyloric Antrum - cytology</subject><subject>Pyloric Antrum - enzymology</subject><subject>Pyloric Antrum - innervation</subject><subject>Smooth muscle</subject><subject>Stomach</subject><issn>0948-6143</issn><issn>1432-119X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0E1LxDAQBuAgiruuHr1KQBBFqpOPJs1R1k9Y8KIgeChpm7pZ22ZNUnH_vV3Wg3oamHl4GV6EDglcEAB5GQA4yQBS4CnbQmPCGU0IUS_baAyKZ4kYNiO0F8ICgKSK0l00IpCmIIgco9drG6K3RR-t67Cr8dy0Bruv1ZvpdDCYYtvhzvhPE7DuKlwm7zaenp8N62h8iDZa3eDSNE1Yy3nf6g6H6FpdzvfRTq2bYA5-5gQ93948Te-T2ePdw_RqlpSMyJhQKSvKspTxSlZKyCLlXOmaMEqUNJqDHi6CsCIrasgo0UKXRc1BpJmsa5mxCTrZ5C69--hNiHlrw_ol3RnXh1woJkFyMcDjf3Dhet8Nv-WUD0IpKtigko0qvQvBmzpfettqv8oJ5OvO8z-dD_7oJ7UvWlP90puS2TcoB3ng</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Porcher, C</creator><creator>Orsoni, P</creator><creator>Berdah, S</creator><creator>Monges, G</creator><creator>Mazet, B</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Distribution of heme oxygenase 2 in nerves and c-kit(+) interstitial cells in human stomach</title><author>Porcher, C ; Orsoni, P ; Berdah, S ; Monges, G ; Mazet, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-277d238534d7d967b5449af132197ea40a34d613b8bf0821a6acbf406587ff783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>c-Kit protein</topic><topic>Carbon monoxide</topic><topic>Cell Communication</topic><topic>Confocal microscopy</topic><topic>Enteric nervous system</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Ganglia</topic><topic>Gastric motility</topic><topic>Heme</topic><topic>Heme Oxygenase (Decyclizing) - metabolism</topic><topic>Humans</topic><topic>Immunoreactivity</topic><topic>Interstitial cells</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Smooth - innervation</topic><topic>Myenteric plexus</topic><topic>Myenteric Plexus - cytology</topic><topic>Myenteric Plexus - enzymology</topic><topic>Nerve Fibers - enzymology</topic><topic>Nerves</topic><topic>Neurons - enzymology</topic><topic>Oxygenase</topic><topic>Pacemakers</topic><topic>Proto-Oncogene Proteins c-kit - metabolism</topic><topic>Pyloric Antrum - cytology</topic><topic>Pyloric Antrum - enzymology</topic><topic>Pyloric Antrum - innervation</topic><topic>Smooth muscle</topic><topic>Stomach</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Porcher, C</creatorcontrib><creatorcontrib>Orsoni, P</creatorcontrib><creatorcontrib>Berdah, S</creatorcontrib><creatorcontrib>Monges, G</creatorcontrib><creatorcontrib>Mazet, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Histochemistry and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Porcher, C</au><au>Orsoni, P</au><au>Berdah, S</au><au>Monges, G</au><au>Mazet, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of heme oxygenase 2 in nerves and c-kit(+) interstitial cells in human stomach</atitle><jtitle>Histochemistry and cell biology</jtitle><addtitle>Histochem Cell Biol</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>112</volume><issue>4</issue><spage>317</spage><epage>322</epage><pages>317-322</pages><issn>0948-6143</issn><eissn>1432-119X</eissn><abstract>Different populations of interstitial cells (ICs) may serve as gut pacemakers or as intermediaries between enteric nerves and smooth muscle cells. However, very little is known about the substances that ICs might use to communicate with other cells and no data are available in humans. Because carbon monoxide (CO) is emerging as a putative mediator in the regulation of gastrointestinal motility, this study examined the presence of heme oxygenase (HO2), the constitutive form of the enzyme for CO production, in human stomach with particular attention to ICs. The distribution of HO2 in nerves and ICs in human antrum was studied using specific antibodies. The immunostaining was observed using confocal laser scanning microscopy. HO2 immunoreactivity was found in myenteric neurons and nerve fibers supplying the circular muscle layer and in intramuscular c-kit(+) ICs, but not in c-kit(+) ICs surrounding the myenteric ganglia. The presence of HO2 in different cell types suggests that CO may serve as an intercellular messenger between myenteric neurons and ICs and between ICs and smooth muscle cells in human stomach.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>10550617</pmid><doi>10.1007/s004180050453</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Aged, 80 and over c-Kit protein Carbon monoxide Cell Communication Confocal microscopy Enteric nervous system Female Fluorescent Antibody Technique, Indirect Ganglia Gastric motility Heme Heme Oxygenase (Decyclizing) - metabolism Humans Immunoreactivity Interstitial cells Male Middle Aged Muscle, Smooth - innervation Myenteric plexus Myenteric Plexus - cytology Myenteric Plexus - enzymology Nerve Fibers - enzymology Nerves Neurons - enzymology Oxygenase Pacemakers Proto-Oncogene Proteins c-kit - metabolism Pyloric Antrum - cytology Pyloric Antrum - enzymology Pyloric Antrum - innervation Smooth muscle Stomach |
| title | Distribution of heme oxygenase 2 in nerves and c-kit(+) interstitial cells in human stomach |
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