α‐Difluoromethylornithine Blocks Thymocyte Apoptosis Via a Reduction in Tyrosine Phosphorylation

The effect of α‐difluoromethylornithine on cell apoptosis was investigated. Freshly isolated mouse thymocytes were cultured in the medium alone or with dexamethasone, and apoptotic cell death was monitored after 6 h. A correlation was seen between cell apoptosis and a reduction in the polyamine leve...

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Veröffentlicht in:	Scandinavian journal of immunology 1999-12, Vol.50 (6), p.605-611
Hauptverfasser:	Jan, M S, Wing, L Y, Lin, M T, Lin, Y S
Format:	Artikel
Sprache:	eng
Schlagworte:	a-difluoromethylornithine Animals Apoptosis - drug effects Arsenicals - pharmacology Cells, Cultured dexamethasone Dexamethasone - pharmacology Eflornithine - pharmacology Enzyme Inhibitors - pharmacology Female Male Mice Mice, Inbred BALB C Ornithine Decarboxylase Inhibitors Phosphorylation - drug effects Polyamines - analysis Protein Processing, Post-Translational - drug effects Protein Tyrosine Phosphatases - antagonists & inhibitors Signal Transduction - drug effects T-Lymphocytes - cytology T-Lymphocytes - drug effects Thymus Gland - cytology tyrosine
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