Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase

A unique enzyme, MMA(V) reductase, has been partially purified from rabbit liver by using DEAE-cellulose, carboxymethylcellulose, and red dye ligand chromatography. The enzyme is unique since it is the rate-limiting enzyme in the biotransformation of inorganic arsenite in rabbit liver. The K(m) and...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical research in toxicology 1999-12, Vol.12 (12), p.1278-1283
Hauptverfasser:	Zakharyan, R A, Aposhian, H V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenicals - pharmacokinetics Biotransformation Humans Hydrogen-Ion Concentration Liver - enzymology Male Metabolic Clearance Rate Methyltransferases - isolation & purification Methyltransferases - metabolism Oxidation-Reduction Rabbits Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!