The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy

The hepatitis C virus (HCV) is a major causative agent of transfusion‐acquired and sporadic non‐A, non‐B hepatitis worldwide. Infections most often persist and lead, in ≈ 50% of all patients, to chronic liver disease. As is characteristic for a member of the family Flaviviridae, HCV has a plus‐stran...

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