Gene expression profiles of human chondrocytes during passaged monolayer cultivation

Chondrocyte phenotype has been shown to dedifferentiate during passaged monolayer cultivation. Hence, we have investigated the expression profile of 27 chondrocyte‐associated genes from both osteoarthritic cartilage tissue and healthy passaged human articular chondrocytes by quantitative real‐time P...

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Veröffentlicht in:	Journal of orthopaedic research 2008-09, Vol.26 (9), p.1230-1237
Hauptverfasser:	Lin, Zhen, Fitzgerald, Jonathan B., Xu, Jiake, Willers, Craig, Wood, David, Grodzinsky, Alan J., Zheng, Ming H.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics ADAMTS4 Protein ADAMTS5 Protein Aggrecans - genetics Cartilage, Articular - metabolism Cell Culture Techniques chondrocyte Chondrocytes - metabolism Collagen Type II - genetics dedifferentiation Extracellular Matrix Proteins - genetics Fibromodulin Fibronectins - genetics Gene Expression Gene Expression Profiling Humans IL-1beta insulin-like growth factor (IGF-1) Insulin-Like Growth Factor I - genetics Interleukin-1 - genetics interleukin-1beta Knee Joint - metabolism Matrix Metalloproteinases, Secreted - genetics Polymerase Chain Reaction Procollagen N-Endopeptidase - genetics Proteoglycans - genetics real-time RT-PCR Reverse Transcription RNA - isolation & purification Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-3 - genetics Transcription Factors - genetics Transforming Growth Factor beta - genetics
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