State-of-the-Art of Serum Testosterone Measurement by Isotope Dilution-Liquid Chromatography- Tandem Mass Spectrometry

The recent interest of clinical laboratories in developing serum testosterone assays based on isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) stems from the lack of accuracy of direct immunoassays. In this study, we assessed the accuracy and state of standardization (tr...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2008-08, Vol.54 (8), p.1290-1297
Hauptverfasser:	Thienpont, Linda M, Van Uytfanghe, Katleen, Blincko, Stuart, Ramsay, Carol S, Xie, Hui, Doss, Robert C, Keevil, Brian G, Owen, Laura J, Rockwood, Alan L, Kushnir, Mark M, Chun, Kelly Y, Chandler, Donald W, Field, Helen P, Sluss, Patrick M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analytical, structural and metabolic biochemistry Androgens Biological and medical sciences Calibration Carbon Isotopes Chromatography Chromatography, Liquid - methods Committees Correlation coefficient Female Females Fundamental and applied biological sciences. Psychology Gas chromatography Hospitals Humans Hypogonadism - blood Immunoassays Indicator Dilution Techniques Investigative techniques, diagnostic techniques (general aspects) Laboratories Liquid chromatography Male Mass spectrometry Medical sciences Methods Middle Aged Reference Standards Regression Analysis Reproducibility of Results Sensitivity and Specificity Specimen Handling Spectrum analysis Standardization Tandem Mass Spectrometry - methods Testosterone Testosterone - blood
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