Short hairpin RNA-mediated inhibition of HSV-1 gene expression and function during HSV-1 infection in Vero cells

Aim： To evaluate the efficiency of 3 short hairpin RNA （shRNA） interfering with the herpes simplex virus type 1 （HSV-1） gene coding glycoprotein D （gD） for inhibiting the gD expression and virus replication in vitro. Methods： Vero cells were selected for an in vitro model of infection. Three shRNA s...

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Veröffentlicht in:	Acta pharmacologica Sinica 2008-08, Vol.29 (8), p.975-982
Hauptverfasser:	Liu, Yuan-yuan, Deng, Hai-ying, Yang, Guang, Jiang, Wen-lin, Grossin, Laurent, Yang, Zhan-qiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antivirus Biomedical and Life Sciences Biomedicine Cercopithecus aethiops Cytopathogenic Effect, Viral - drug effects Gene Expression Regulation, Viral - genetics Gene Expression Regulation, Viral - physiology glycoprotein D Herpes simplex virus 1 herpes simplex virus type 1 Herpesvirus 1, Human - genetics Herpesvirus 1, Human - physiology HSV-1基因 Immunology in vitro Internal Medicine Inverted Repeat Sequences - genetics Medical Microbiology original-article Pharmacology/Toxicology Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Viral - biosynthesis RNA, Viral - genetics RNA, Viral - physiology short hairpin RNA Transfection Vaccine Vero Cells Viral Envelope Proteins - biosynthesis Viral Envelope Proteins - genetics Virus Replication - drug effects 糖蛋白D
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