Catalytic Asymmetric Synthesis of 2,2-Disubstituted Terminal Epoxides via Dimethyloxosulfonium Methylide Addition to Ketones

Catalytic asymmetric Corey−Chaykovsky epoxidation of ketones with dimethyloxosulfonium methylide 2 using an LLB 1a + Ar3PO complex proceeded smoothly at room temperature, and 2,2-disubstituted terminal epoxides were obtained in high enantioselectivity (91−97%) and yield (>88−99%) from a broad ra...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-08, Vol.130 (31), p.10078-10079
Hauptverfasser:	Sone, Toshihiko, Yamaguchi, Akitake, Matsunaga, Shigeki, Shibasaki, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Epoxy Compounds - chemical synthesis Ketones - chemistry Organophosphorus Compounds Sulfonium Compounds - chemistry
Online-Zugang:	Volltext
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