Sequence-specific DNA recognition by polyamides

Sequence-specific DNA recognition by polyamides

Sequence-specific DNA-binding small molecules that can permeate cells could potentially regulate transcription of specific genes. Simple pairing rules for the minor groove of the double helix have been developed that allow the design of ligands for predetermined DNA sequences. Some of these polyamid...

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Veröffentlicht in:Current Opinion in Chemical Biology 1999-12, Vol.3 (6), p.688-693
Hauptverfasser: Dervan, Peter B, Bürli, Roland W
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
DNA - chemistry
DNA recognition
Inhibition
Nylons - chemistry
Pairing rules
Polyamides
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Zusammenfassung:Sequence-specific DNA-binding small molecules that can permeate cells could potentially regulate transcription of specific genes. Simple pairing rules for the minor groove of the double helix have been developed that allow the design of ligands for predetermined DNA sequences. Some of these polyamides have been shown to inhibit specific gene expression in mammalian cell culture.
ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(99)00027-7