Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression
The aim of this study was to evaluate whether deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVH) are associated with suicidal behavior in patients with major affective disorders. Subjects were 99 consecutively admitted inpatients (42 men; 57 women; mean...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2008-08, Vol.32 (6), p.1501-1507 |
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| creator | Pompili, Maurizio Innamorati, Marco Mann, J. John Oquendo, Maria A. Lester, David Del Casale, Antonio Serafini, Gianluca Rigucci, Silvia Romano, Andrea Tamburello, Antonino Manfredi, Giovanni De Pisa, Eleonora Ehrlich, Stefan Giupponi, Giancarlo Amore, Mario Tatarelli, Roberto Girardi, Paolo |
| description | The aim of this study was to evaluate whether deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVH) are associated with suicidal behavior in patients with major affective disorders. Subjects were 99 consecutively admitted inpatients (42 men; 57 women; mean age: 46.5 years [SD
=
15.2; Min./Max.
=
19/79]) with a diagnosis of major affective disorder (bipolar disorder type I, bipolar disorder type-II and unipolar major depressive disorder). 44.4% of the participants had made at least one previous suicide attempt. T2-weighted brain magnetic resonance images were rated for the presence and extension of WMH using the modified Fazekas scale. Patients were interviewed for clinical data on average 5 days after admission. Bivariate analyses, corrected for multiple-testing, and logistic regression analysis were used to test the association between suicide attempts and clinical variables. Attempters and nonattempters differed only in the presence of PVH—the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders. |
| doi_str_mv | 10.1016/j.pnpbp.2008.05.009 |
| format | Article |
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=
15.2; Min./Max.
=
19/79]) with a diagnosis of major affective disorder (bipolar disorder type I, bipolar disorder type-II and unipolar major depressive disorder). 44.4% of the participants had made at least one previous suicide attempt. T2-weighted brain magnetic resonance images were rated for the presence and extension of WMH using the modified Fazekas scale. Patients were interviewed for clinical data on average 5 days after admission. Bivariate analyses, corrected for multiple-testing, and logistic regression analysis were used to test the association between suicide attempts and clinical variables. Attempters and nonattempters differed only in the presence of PVH—the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2008.05.009</identifier><identifier>PMID: 18572296</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Analysis of Variance ; Biological and medical sciences ; Bipolar disorder ; Bipolar Disorder - pathology ; Bipolar Disorder - psychology ; Bipolar disorders ; Cerebral Ventricles - pathology ; Depression ; Depressive Disorder - pathology ; Depressive Disorder - psychology ; Female ; Humans ; Interview, Psychological ; Italy - epidemiology ; Logistic Models ; Magnetic Resonance Imaging ; Major affective disorders ; Major depressive disorder ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Neuropharmacology ; Odds Ratio ; Pharmacology. Drug treatments ; Predictive Value of Tests ; Prognosis ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Assessment ; Suicide ; Suicide, Attempted - psychology ; White matter hyperintensities</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2008-08, Vol.32 (6), p.1501-1507</ispartof><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-de10f06a527ea04b9e7f1aee26981830d3ef900118757b8de35612a01d52c4b73</citedby><cites>FETCH-LOGICAL-c484t-de10f06a527ea04b9e7f1aee26981830d3ef900118757b8de35612a01d52c4b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2008.05.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20593079$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18572296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pompili, Maurizio</creatorcontrib><creatorcontrib>Innamorati, Marco</creatorcontrib><creatorcontrib>Mann, J. John</creatorcontrib><creatorcontrib>Oquendo, Maria A.</creatorcontrib><creatorcontrib>Lester, David</creatorcontrib><creatorcontrib>Del Casale, Antonio</creatorcontrib><creatorcontrib>Serafini, Gianluca</creatorcontrib><creatorcontrib>Rigucci, Silvia</creatorcontrib><creatorcontrib>Romano, Andrea</creatorcontrib><creatorcontrib>Tamburello, Antonino</creatorcontrib><creatorcontrib>Manfredi, Giovanni</creatorcontrib><creatorcontrib>De Pisa, Eleonora</creatorcontrib><creatorcontrib>Ehrlich, Stefan</creatorcontrib><creatorcontrib>Giupponi, Giancarlo</creatorcontrib><creatorcontrib>Amore, Mario</creatorcontrib><creatorcontrib>Tatarelli, Roberto</creatorcontrib><creatorcontrib>Girardi, Paolo</creatorcontrib><title>Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>The aim of this study was to evaluate whether deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVH) are associated with suicidal behavior in patients with major affective disorders. Subjects were 99 consecutively admitted inpatients (42 men; 57 women; mean age: 46.5 years [SD
=
15.2; Min./Max.
=
19/79]) with a diagnosis of major affective disorder (bipolar disorder type I, bipolar disorder type-II and unipolar major depressive disorder). 44.4% of the participants had made at least one previous suicide attempt. T2-weighted brain magnetic resonance images were rated for the presence and extension of WMH using the modified Fazekas scale. Patients were interviewed for clinical data on average 5 days after admission. Bivariate analyses, corrected for multiple-testing, and logistic regression analysis were used to test the association between suicide attempts and clinical variables. Attempters and nonattempters differed only in the presence of PVH—the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders.</description><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - pathology</subject><subject>Bipolar Disorder - psychology</subject><subject>Bipolar disorders</subject><subject>Cerebral Ventricles - pathology</subject><subject>Depression</subject><subject>Depressive Disorder - pathology</subject><subject>Depressive Disorder - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Interview, Psychological</subject><subject>Italy - epidemiology</subject><subject>Logistic Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Major affective disorders</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Neuropharmacology</subject><subject>Odds Ratio</subject><subject>Pharmacology. Drug treatments</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Assessment</subject><subject>Suicide</subject><subject>Suicide, Attempted - psychology</subject><subject>White matter hyperintensities</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6CwTJRW_TVpJOfxw8yOIXLOhBzyGdVLMZetJtKr3Lgj_etDPqTU8pkqdeUvUw9lxAJUA0rw_VEpdhqSRAV4GuAPoHbCe6ttvXUjQP2Q5kqXVXNxfsCdEBAIQC9ZhdiE63UvbNjv34gincYswpuHWyid_dhIz8aHPGxG_ul_IcM0YKOSBxS3xJ6IPLcyI-j5zW4IJHvvHHJRMPkQ9hmbcoH2hOHgtoo-dr_H2NJYIozPEpezTaifDZ-bxk396_-3r1cX_9-cOnq7fXe1d3dd57FDBCY7Vs0UI99NiOwiLKpu9Ep8ArHPsyWxldt0PnUelGSAvCa-nqoVWX7NUpd0nz9xUpm2Mgh9NkI84rmaZXjdSg_wtKKJjq6gKqE-jSTJRwNEsKR5vujQCz2TEH88uO2ewY0KbYKV0vzvHrcET_t-esowAvz4AlZ6cx2egC_eEk6F5BuwW9OXFYtnYbMBlyAaMrZhK6bPwc_vmRn630sbo</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Pompili, Maurizio</creator><creator>Innamorati, Marco</creator><creator>Mann, J. John</creator><creator>Oquendo, Maria A.</creator><creator>Lester, David</creator><creator>Del Casale, Antonio</creator><creator>Serafini, Gianluca</creator><creator>Rigucci, Silvia</creator><creator>Romano, Andrea</creator><creator>Tamburello, Antonino</creator><creator>Manfredi, Giovanni</creator><creator>De Pisa, Eleonora</creator><creator>Ehrlich, Stefan</creator><creator>Giupponi, Giancarlo</creator><creator>Amore, Mario</creator><creator>Tatarelli, Roberto</creator><creator>Girardi, Paolo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression</title><author>Pompili, Maurizio ; Innamorati, Marco ; Mann, J. John ; Oquendo, Maria A. ; Lester, David ; Del Casale, Antonio ; Serafini, Gianluca ; Rigucci, Silvia ; Romano, Andrea ; Tamburello, Antonino ; Manfredi, Giovanni ; De Pisa, Eleonora ; Ehrlich, Stefan ; Giupponi, Giancarlo ; Amore, Mario ; Tatarelli, Roberto ; Girardi, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-de10f06a527ea04b9e7f1aee26981830d3ef900118757b8de35612a01d52c4b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - pathology</topic><topic>Bipolar Disorder - psychology</topic><topic>Bipolar disorders</topic><topic>Cerebral Ventricles - pathology</topic><topic>Depression</topic><topic>Depressive Disorder - pathology</topic><topic>Depressive Disorder - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Interview, Psychological</topic><topic>Italy - epidemiology</topic><topic>Logistic Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Major affective disorders</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Neuropharmacology</topic><topic>Odds Ratio</topic><topic>Pharmacology. Drug treatments</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Assessment</topic><topic>Suicide</topic><topic>Suicide, Attempted - psychology</topic><topic>White matter hyperintensities</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pompili, Maurizio</creatorcontrib><creatorcontrib>Innamorati, Marco</creatorcontrib><creatorcontrib>Mann, J. John</creatorcontrib><creatorcontrib>Oquendo, Maria A.</creatorcontrib><creatorcontrib>Lester, David</creatorcontrib><creatorcontrib>Del Casale, Antonio</creatorcontrib><creatorcontrib>Serafini, Gianluca</creatorcontrib><creatorcontrib>Rigucci, Silvia</creatorcontrib><creatorcontrib>Romano, Andrea</creatorcontrib><creatorcontrib>Tamburello, Antonino</creatorcontrib><creatorcontrib>Manfredi, Giovanni</creatorcontrib><creatorcontrib>De Pisa, Eleonora</creatorcontrib><creatorcontrib>Ehrlich, Stefan</creatorcontrib><creatorcontrib>Giupponi, Giancarlo</creatorcontrib><creatorcontrib>Amore, Mario</creatorcontrib><creatorcontrib>Tatarelli, Roberto</creatorcontrib><creatorcontrib>Girardi, Paolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pompili, Maurizio</au><au>Innamorati, Marco</au><au>Mann, J. John</au><au>Oquendo, Maria A.</au><au>Lester, David</au><au>Del Casale, Antonio</au><au>Serafini, Gianluca</au><au>Rigucci, Silvia</au><au>Romano, Andrea</au><au>Tamburello, Antonino</au><au>Manfredi, Giovanni</au><au>De Pisa, Eleonora</au><au>Ehrlich, Stefan</au><au>Giupponi, Giancarlo</au><au>Amore, Mario</au><au>Tatarelli, Roberto</au><au>Girardi, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>32</volume><issue>6</issue><spage>1501</spage><epage>1507</epage><pages>1501-1507</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>The aim of this study was to evaluate whether deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVH) are associated with suicidal behavior in patients with major affective disorders. Subjects were 99 consecutively admitted inpatients (42 men; 57 women; mean age: 46.5 years [SD
=
15.2; Min./Max.
=
19/79]) with a diagnosis of major affective disorder (bipolar disorder type I, bipolar disorder type-II and unipolar major depressive disorder). 44.4% of the participants had made at least one previous suicide attempt. T2-weighted brain magnetic resonance images were rated for the presence and extension of WMH using the modified Fazekas scale. Patients were interviewed for clinical data on average 5 days after admission. Bivariate analyses, corrected for multiple-testing, and logistic regression analysis were used to test the association between suicide attempts and clinical variables. Attempters and nonattempters differed only in the presence of PVH—the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>18572296</pmid><doi>10.1016/j.pnpbp.2008.05.009</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Analysis of Variance Biological and medical sciences Bipolar disorder Bipolar Disorder - pathology Bipolar Disorder - psychology Bipolar disorders Cerebral Ventricles - pathology Depression Depressive Disorder - pathology Depressive Disorder - psychology Female Humans Interview, Psychological Italy - epidemiology Logistic Models Magnetic Resonance Imaging Major affective disorders Major depressive disorder Male Medical sciences Middle Aged Mood disorders Neuropharmacology Odds Ratio Pharmacology. Drug treatments Predictive Value of Tests Prognosis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Assessment Suicide Suicide, Attempted - psychology White matter hyperintensities |
| title | Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression |
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