Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice : Evidence for increased tumor cell apoptosis in vivo

Poly(ADP-ribose) polymerase (PARP4) catalyzes the formation of ADP-ribose polymers covalently attached to proteins by using NAD+ as substrate. PARP is strongly activated by DNA single- or double-strand breaks and is thought to be involved in cellular responses to DNA damage. We characterized a domin...

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Veröffentlicht in:	Oncogene 1999-11, Vol.18 (50), p.7010-7015
Hauptverfasser:	HANS, M.-A, MÜLLER, M, MEYER-FICCA, M, BÜRKLE, A, KÜPPER, J.-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Base excision repair Biological and medical sciences Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cloning Deoxyribonucleic acid DNA DNA damage DNA repair Enzymatic activity Enzymes Fundamental and applied biological sciences. Psychology Genomic instability HeLa Cells Humans Mice Mice, Nude Molecular and cellular biology NAD Neoplasms, Experimental - enzymology Neoplasms, Experimental - pathology Poly(ADP-ribose) Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - genetics Recombination Ribose Tumorigenesis
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