Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network
The regulation and maintenance of systemic iron homeostasis is critical to human health. Iron overload and deficiency diseases belong to the most common nutrition-related pathologies across the globe. It is now well appreciated that the hormonal hepcidin/ferroportin system plays an important regulat...
Gespeichert in:
| Veröffentlicht in: | Annual review of nutrition 2008-01, Vol.28 (1), p.197-213 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 213 |
|---|---|
| container_issue | 1 |
| container_start_page | 197 |
| container_title | Annual review of nutrition |
| container_volume | 28 |
| creator | Muckenthaler, Martina U Galy, Bruno Hentze, Matthias W |
| description | The regulation and maintenance of systemic iron homeostasis is critical to human health. Iron overload and deficiency diseases belong to the most common nutrition-related pathologies across the globe. It is now well appreciated that the hormonal hepcidin/ferroportin system plays an important regulatory role for systemic iron metabolism. We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis. We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance. |
| doi_str_mv | 10.1146/annurev.nutr.28.061807.155521 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69359347</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69359347</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-d03d83629c3452f8f3f061d14c43966b06c7facd251c3d9c69947a84fa75fbe13</originalsourceid><addsrcrecordid>eNpNkE1P3DAQhi3Uqiy0f4HmAqKHZP0d-8ABoaWshFq0lLPldWyaNrEX2wHtvyc0UdvTSDPPO6N5ADhFsEKI8qX2foj2ufJDjhUWFeRIwLpCjDGMDsACMcpKShB-BxYQSVlKIdghOErpF4RQEkI-gEMkqJCY1Qvg7_cp2741xToGX9yE3oaUdWpToX1T5J_2z6Dc2LQLPrXPtlh1trc-L-f-49DpHOK-uIsh29YX5-vNarne3H0p_ht-s_klxN8fwXunu2Q_zfUYPFyvflzdlLffv66vLm9LQynJZQNJIwjH0hDKsBOOuPHPBlFDieR8C7mpnTYNZsiQRhouJa21oE7XzG0tIsfgbNq7i-FpsCmrvk3Gdp32NgxJcUmYJLQewYsJNDGkFK1Tu9j2Ou4VgupNuJqFqzfhCgs1CVeT8DF_Mh8atr1t_qVnwyNwOgM6Gd25qL1p018OQ0lhjeXIfZ44p4PSj3FkHu4xRAQiRrjEgrwCnt6Xzw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69359347</pqid></control><display><type>article</type><title>Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network</title><source>Annual Reviews Complete A-Z List</source><source>MEDLINE</source><creator>Muckenthaler, Martina U ; Galy, Bruno ; Hentze, Matthias W</creator><creatorcontrib>Muckenthaler, Martina U ; Galy, Bruno ; Hentze, Matthias W</creatorcontrib><description>The regulation and maintenance of systemic iron homeostasis is critical to human health. Iron overload and deficiency diseases belong to the most common nutrition-related pathologies across the globe. It is now well appreciated that the hormonal hepcidin/ferroportin system plays an important regulatory role for systemic iron metabolism. We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis. We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance.</description><identifier>ISSN: 0199-9885</identifier><identifier>EISSN: 1545-4312</identifier><identifier>DOI: 10.1146/annurev.nutr.28.061807.155521</identifier><identifier>PMID: 18489257</identifier><identifier>CODEN: ARNTD8</identifier><language>eng</language><publisher>Palo Alto, CA: Annual Reviews</publisher><subject>Animals ; biochemical pathways ; Biological and medical sciences ; deficiency diseases ; dietary minerals ; Feeding. Feeding behavior ; ferroportin ; Fundamental and applied biological sciences. Psychology ; hepcidin ; Homeostasis ; Humans ; iron ; Iron - blood ; Iron - deficiency ; Iron-Regulatory Proteins - physiology ; literature reviews ; mineral metabolism ; nutrient deficiencies ; nutrient excess ; peptide hormones ; Response Elements - physiology ; transmembrane proteins ; transport proteins ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Annual review of nutrition, 2008-01, Vol.28 (1), p.197-213</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-d03d83629c3452f8f3f061d14c43966b06c7facd251c3d9c69947a84fa75fbe13</citedby><cites>FETCH-LOGICAL-c443t-d03d83629c3452f8f3f061d14c43966b06c7facd251c3d9c69947a84fa75fbe13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4170,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20940729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18489257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muckenthaler, Martina U</creatorcontrib><creatorcontrib>Galy, Bruno</creatorcontrib><creatorcontrib>Hentze, Matthias W</creatorcontrib><title>Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network</title><title>Annual review of nutrition</title><addtitle>Annu Rev Nutr</addtitle><description>The regulation and maintenance of systemic iron homeostasis is critical to human health. Iron overload and deficiency diseases belong to the most common nutrition-related pathologies across the globe. It is now well appreciated that the hormonal hepcidin/ferroportin system plays an important regulatory role for systemic iron metabolism. We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis. We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance.</description><subject>Animals</subject><subject>biochemical pathways</subject><subject>Biological and medical sciences</subject><subject>deficiency diseases</subject><subject>dietary minerals</subject><subject>Feeding. Feeding behavior</subject><subject>ferroportin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hepcidin</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>iron</subject><subject>Iron - blood</subject><subject>Iron - deficiency</subject><subject>Iron-Regulatory Proteins - physiology</subject><subject>literature reviews</subject><subject>mineral metabolism</subject><subject>nutrient deficiencies</subject><subject>nutrient excess</subject><subject>peptide hormones</subject><subject>Response Elements - physiology</subject><subject>transmembrane proteins</subject><subject>transport proteins</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0199-9885</issn><issn>1545-4312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1P3DAQhi3Uqiy0f4HmAqKHZP0d-8ABoaWshFq0lLPldWyaNrEX2wHtvyc0UdvTSDPPO6N5ADhFsEKI8qX2foj2ufJDjhUWFeRIwLpCjDGMDsACMcpKShB-BxYQSVlKIdghOErpF4RQEkI-gEMkqJCY1Qvg7_cp2741xToGX9yE3oaUdWpToX1T5J_2z6Dc2LQLPrXPtlh1trc-L-f-49DpHOK-uIsh29YX5-vNarne3H0p_ht-s_klxN8fwXunu2Q_zfUYPFyvflzdlLffv66vLm9LQynJZQNJIwjH0hDKsBOOuPHPBlFDieR8C7mpnTYNZsiQRhouJa21oE7XzG0tIsfgbNq7i-FpsCmrvk3Gdp32NgxJcUmYJLQewYsJNDGkFK1Tu9j2Ou4VgupNuJqFqzfhCgs1CVeT8DF_Mh8atr1t_qVnwyNwOgM6Gd25qL1p018OQ0lhjeXIfZ44p4PSj3FkHu4xRAQiRrjEgrwCnt6Xzw</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Muckenthaler, Martina U</creator><creator>Galy, Bruno</creator><creator>Hentze, Matthias W</creator><general>Annual Reviews</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network</title><author>Muckenthaler, Martina U ; Galy, Bruno ; Hentze, Matthias W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-d03d83629c3452f8f3f061d14c43966b06c7facd251c3d9c69947a84fa75fbe13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>biochemical pathways</topic><topic>Biological and medical sciences</topic><topic>deficiency diseases</topic><topic>dietary minerals</topic><topic>Feeding. Feeding behavior</topic><topic>ferroportin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hepcidin</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>iron</topic><topic>Iron - blood</topic><topic>Iron - deficiency</topic><topic>Iron-Regulatory Proteins - physiology</topic><topic>literature reviews</topic><topic>mineral metabolism</topic><topic>nutrient deficiencies</topic><topic>nutrient excess</topic><topic>peptide hormones</topic><topic>Response Elements - physiology</topic><topic>transmembrane proteins</topic><topic>transport proteins</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muckenthaler, Martina U</creatorcontrib><creatorcontrib>Galy, Bruno</creatorcontrib><creatorcontrib>Hentze, Matthias W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muckenthaler, Martina U</au><au>Galy, Bruno</au><au>Hentze, Matthias W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network</atitle><jtitle>Annual review of nutrition</jtitle><addtitle>Annu Rev Nutr</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>28</volume><issue>1</issue><spage>197</spage><epage>213</epage><pages>197-213</pages><issn>0199-9885</issn><eissn>1545-4312</eissn><coden>ARNTD8</coden><abstract>The regulation and maintenance of systemic iron homeostasis is critical to human health. Iron overload and deficiency diseases belong to the most common nutrition-related pathologies across the globe. It is now well appreciated that the hormonal hepcidin/ferroportin system plays an important regulatory role for systemic iron metabolism. We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis. We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance.</abstract><cop>Palo Alto, CA</cop><pub>Annual Reviews</pub><pmid>18489257</pmid><doi>10.1146/annurev.nutr.28.061807.155521</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0199-9885 |
| ispartof | Annual review of nutrition, 2008-01, Vol.28 (1), p.197-213 |
| issn | 0199-9885 1545-4312 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69359347 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Animals biochemical pathways Biological and medical sciences deficiency diseases dietary minerals Feeding. Feeding behavior ferroportin Fundamental and applied biological sciences. Psychology hepcidin Homeostasis Humans iron Iron - blood Iron - deficiency Iron-Regulatory Proteins - physiology literature reviews mineral metabolism nutrient deficiencies nutrient excess peptide hormones Response Elements - physiology transmembrane proteins transport proteins Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T22%3A24%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Systemic%20Iron%20Homeostasis%20and%20the%20Iron-Responsive%20Element/Iron-Regulatory%20Protein%20(IRE/IRP)%20Regulatory%20Network&rft.jtitle=Annual%20review%20of%20nutrition&rft.au=Muckenthaler,%20Martina%20U&rft.date=2008-01-01&rft.volume=28&rft.issue=1&rft.spage=197&rft.epage=213&rft.pages=197-213&rft.issn=0199-9885&rft.eissn=1545-4312&rft.coden=ARNTD8&rft_id=info:doi/10.1146/annurev.nutr.28.061807.155521&rft_dat=%3Cproquest_cross%3E69359347%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69359347&rft_id=info:pmid/18489257&rfr_iscdi=true |