Effects of low-fat stanol ester enriched margarines on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations
To investigate the effects of low-fat stanol ester margarines on concentrations of serum carotenoids. A randomized parallel double-blind study design consisting of a 4-week run-in (high-fat diet) and an 8-week experimental (low-fat, low-cholesterol diet) period. During the experimental diet period s...
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| Veröffentlicht in: | European journal of clinical nutrition 1999-12, Vol.53 (12), p.966-969 |
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| creator | HALLIKAINEN, M. A SARKKINEN, E. S UUSITUPA, M. I. J |
| description | To investigate the effects of low-fat stanol ester margarines on concentrations of serum carotenoids.
A randomized parallel double-blind study design consisting of a 4-week run-in (high-fat diet) and an 8-week experimental (low-fat, low-cholesterol diet) period. During the experimental diet period subjects consumed low-fat wood stanol ester (WSEM), vegetable oil stanol ester (VOSEM) or control (no stanol esters) margarine daily. The daily mean total stanol intake was 2.31 and 2.16 g in the WSEM and VOSEM groups, respectively.
Outpatient clinical trial with free-living subjects.
Altogether, 60 hypercholesterolaemic subjects were selected for the study out of 91 originally screened. The study was completed by 55 subjects.
Serum alpha- and beta-carotene and lycopene determined by the HPLC.
Serum alpha-carotene concentration did not change significantly in either of the experimental groups, whereas beta-carotene concentration decreased significantly in the WSEM and VOSEM groups (P |
| doi_str_mv | 10.1038/sj.ejcn.1600882 |
| format | Article |
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A randomized parallel double-blind study design consisting of a 4-week run-in (high-fat diet) and an 8-week experimental (low-fat, low-cholesterol diet) period. During the experimental diet period subjects consumed low-fat wood stanol ester (WSEM), vegetable oil stanol ester (VOSEM) or control (no stanol esters) margarine daily. The daily mean total stanol intake was 2.31 and 2.16 g in the WSEM and VOSEM groups, respectively.
Outpatient clinical trial with free-living subjects.
Altogether, 60 hypercholesterolaemic subjects were selected for the study out of 91 originally screened. The study was completed by 55 subjects.
Serum alpha- and beta-carotene and lycopene determined by the HPLC.
Serum alpha-carotene concentration did not change significantly in either of the experimental groups, whereas beta-carotene concentration decreased significantly in the WSEM and VOSEM groups (P<0.01), and the change differed significantly (P<0.05 and P <0.01, respectively) from that of the control group. Decrease in alpha+beta-carotene concentration was significantly greater (P <0.05) in both experimental groups than in the control group. However, the change in alpha-, beta- or alpha+beta-carotene/total cholesterol ratio did not differ significantly among the groups. No significant changes were found in serum lycopene or lycopene/total cholesterol ratio in both experimental groups.
Low-fat stanol ester margarines appeared to have little effect on serum concentrations of alpha-, beta- or alpha + beta-carotene, or lycopene.
Grant to the University of Kuopio by Raisio Benecol Ltd, Raisio, Finland.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1600882</identifier><identifier>PMID: 10602355</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Adult ; Anticholesteremic Agents - pharmacology ; beta Carotene - blood ; Biological and medical sciences ; Carotene ; Carotenoids ; Carotenoids - blood ; Cholesterol ; Cholesterol - blood ; Clinical trials ; Diet ; Dietary Fats ; Double-Blind Method ; Esters ; Esters - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; High fat diet ; High-performance liquid chromatography ; Humans ; Hypercholesterolemia - blood ; Hypercholesterolemia - diet therapy ; Lipids. Glycolipids ; Liquid chromatography ; Low fat diet ; Lycopene ; Male ; Margarine ; Metabolisms and neurohumoral controls ; Nutrient deficiency ; Oils & fats ; Phytosterols - pharmacology ; Vegetable oils ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; β-Carotene</subject><ispartof>European journal of clinical nutrition, 1999-12, Vol.53 (12), p.966-969</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Dec 1999</rights><rights>Macmillan Publishers Limited 1999.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-f360584ad437d0b91dab9ec318493c33dbe1bb89e2f3a6001a934bba9eaafdf43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1212417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10602355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HALLIKAINEN, M. A</creatorcontrib><creatorcontrib>SARKKINEN, E. S</creatorcontrib><creatorcontrib>UUSITUPA, M. I. J</creatorcontrib><title>Effects of low-fat stanol ester enriched margarines on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><description>To investigate the effects of low-fat stanol ester margarines on concentrations of serum carotenoids.
A randomized parallel double-blind study design consisting of a 4-week run-in (high-fat diet) and an 8-week experimental (low-fat, low-cholesterol diet) period. During the experimental diet period subjects consumed low-fat wood stanol ester (WSEM), vegetable oil stanol ester (VOSEM) or control (no stanol esters) margarine daily. The daily mean total stanol intake was 2.31 and 2.16 g in the WSEM and VOSEM groups, respectively.
Outpatient clinical trial with free-living subjects.
Altogether, 60 hypercholesterolaemic subjects were selected for the study out of 91 originally screened. The study was completed by 55 subjects.
Serum alpha- and beta-carotene and lycopene determined by the HPLC.
Serum alpha-carotene concentration did not change significantly in either of the experimental groups, whereas beta-carotene concentration decreased significantly in the WSEM and VOSEM groups (P<0.01), and the change differed significantly (P<0.05 and P <0.01, respectively) from that of the control group. Decrease in alpha+beta-carotene concentration was significantly greater (P <0.05) in both experimental groups than in the control group. However, the change in alpha-, beta- or alpha+beta-carotene/total cholesterol ratio did not differ significantly among the groups. No significant changes were found in serum lycopene or lycopene/total cholesterol ratio in both experimental groups.
Low-fat stanol ester margarines appeared to have little effect on serum concentrations of alpha-, beta- or alpha + beta-carotene, or lycopene.
Grant to the University of Kuopio by Raisio Benecol Ltd, Raisio, Finland.</description><subject>Adult</subject><subject>Anticholesteremic Agents - pharmacology</subject><subject>beta Carotene - blood</subject><subject>Biological and medical sciences</subject><subject>Carotene</subject><subject>Carotenoids</subject><subject>Carotenoids - blood</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Clinical trials</subject><subject>Diet</subject><subject>Dietary Fats</subject><subject>Double-Blind Method</subject><subject>Esters</subject><subject>Esters - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>High fat diet</subject><subject>High-performance liquid chromatography</subject><subject>Humans</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - diet therapy</subject><subject>Lipids. Glycolipids</subject><subject>Liquid chromatography</subject><subject>Low fat diet</subject><subject>Lycopene</subject><subject>Male</subject><subject>Margarine</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Nutrient deficiency</subject><subject>Oils & fats</subject><subject>Phytosterols - pharmacology</subject><subject>Vegetable oils</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>β-Carotene</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10Utr3DAQB3BRWppt2nNvRTSlN2_0smwdS0gfEMglPZuxPOraeKVUkhvyQfJ9o-wa-oCedNBv_jPMEPKWsy1nsj1P0xYn67dcM9a24hnZcNXoqtaKPScbZmpVScaaE_IqpYmx8tmIl-SEM82ErOsNebh0Dm1ONDg6h7vKQaYpgw8zxZQxUvRxtDsc6B7iD4ijx2I9tcFb9DlCHoM_VCeMy55aiCGjD-OQ6OhpWvrpEH835h3FGX9BLlmr3YX50KQ0-zvvNXnhYE74Zn1PyffPlzcXX6ur6y_fLj5dVVbxNldOala3CgYlm4H1hg_QG7SSt8pIK-XQI-_71qBwEsqGOBip-h4MArjBKXlKPh5zb2P4uZRZuv2YLM4zeAxL6rSRdWtqXeDZP3AKS_Rltk5oJbQwbc2Kev9fxY3WrOGioPMjsjGkFNF1t3Esy73vOOuejtqlqXs6arcetVS8W2OXfo_DH_54xQI-rACShdlF8HZMv53gQvFGPgIfTK7A</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>HALLIKAINEN, M. A</creator><creator>SARKKINEN, E. S</creator><creator>UUSITUPA, M. I. J</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19991201</creationdate><title>Effects of low-fat stanol ester enriched margarines on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations</title><author>HALLIKAINEN, M. A ; SARKKINEN, E. S ; UUSITUPA, M. I. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-f360584ad437d0b91dab9ec318493c33dbe1bb89e2f3a6001a934bba9eaafdf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Anticholesteremic Agents - pharmacology</topic><topic>beta Carotene - blood</topic><topic>Biological and medical sciences</topic><topic>Carotene</topic><topic>Carotenoids</topic><topic>Carotenoids - blood</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Clinical trials</topic><topic>Diet</topic><topic>Dietary Fats</topic><topic>Double-Blind Method</topic><topic>Esters</topic><topic>Esters - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>High fat diet</topic><topic>High-performance liquid chromatography</topic><topic>Humans</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - diet therapy</topic><topic>Lipids. Glycolipids</topic><topic>Liquid chromatography</topic><topic>Low fat diet</topic><topic>Lycopene</topic><topic>Male</topic><topic>Margarine</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Nutrient deficiency</topic><topic>Oils & fats</topic><topic>Phytosterols - pharmacology</topic><topic>Vegetable oils</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HALLIKAINEN, M. A</creatorcontrib><creatorcontrib>SARKKINEN, E. S</creatorcontrib><creatorcontrib>UUSITUPA, M. I. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HALLIKAINEN, M. A</au><au>SARKKINEN, E. S</au><au>UUSITUPA, M. I. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of low-fat stanol ester enriched margarines on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations</atitle><jtitle>European journal of clinical nutrition</jtitle><addtitle>Eur J Clin Nutr</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>53</volume><issue>12</issue><spage>966</spage><epage>969</epage><pages>966-969</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>To investigate the effects of low-fat stanol ester margarines on concentrations of serum carotenoids.
A randomized parallel double-blind study design consisting of a 4-week run-in (high-fat diet) and an 8-week experimental (low-fat, low-cholesterol diet) period. During the experimental diet period subjects consumed low-fat wood stanol ester (WSEM), vegetable oil stanol ester (VOSEM) or control (no stanol esters) margarine daily. The daily mean total stanol intake was 2.31 and 2.16 g in the WSEM and VOSEM groups, respectively.
Outpatient clinical trial with free-living subjects.
Altogether, 60 hypercholesterolaemic subjects were selected for the study out of 91 originally screened. The study was completed by 55 subjects.
Serum alpha- and beta-carotene and lycopene determined by the HPLC.
Serum alpha-carotene concentration did not change significantly in either of the experimental groups, whereas beta-carotene concentration decreased significantly in the WSEM and VOSEM groups (P<0.01), and the change differed significantly (P<0.05 and P <0.01, respectively) from that of the control group. Decrease in alpha+beta-carotene concentration was significantly greater (P <0.05) in both experimental groups than in the control group. However, the change in alpha-, beta- or alpha+beta-carotene/total cholesterol ratio did not differ significantly among the groups. No significant changes were found in serum lycopene or lycopene/total cholesterol ratio in both experimental groups.
Low-fat stanol ester margarines appeared to have little effect on serum concentrations of alpha-, beta- or alpha + beta-carotene, or lycopene.
Grant to the University of Kuopio by Raisio Benecol Ltd, Raisio, Finland.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>10602355</pmid><doi>10.1038/sj.ejcn.1600882</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of clinical nutrition, 1999-12, Vol.53 (12), p.966-969 |
| issn | 0954-3007 1476-5640 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Adult Anticholesteremic Agents - pharmacology beta Carotene - blood Biological and medical sciences Carotene Carotenoids Carotenoids - blood Cholesterol Cholesterol - blood Clinical trials Diet Dietary Fats Double-Blind Method Esters Esters - pharmacology Female Fundamental and applied biological sciences. Psychology High fat diet High-performance liquid chromatography Humans Hypercholesterolemia - blood Hypercholesterolemia - diet therapy Lipids. Glycolipids Liquid chromatography Low fat diet Lycopene Male Margarine Metabolisms and neurohumoral controls Nutrient deficiency Oils & fats Phytosterols - pharmacology Vegetable oils Vertebrates: anatomy and physiology, studies on body, several organs or systems β-Carotene |
| title | Effects of low-fat stanol ester enriched margarines on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations |
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