Coactivators and nuclear receptor transactivation
A variety of coregulator proteins serve as partners for nuclear receptors orchestrating the molecular events required for receptor‐dependent transcriptional regulation. Some coregulators directly interact with nuclear receptors and provide a platform for recruitment of other factors that provide dis...
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| Veröffentlicht in: | Journal of cellular biochemistry 2008-08, Vol.104 (5), p.1580-1586 |
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| container_end_page | 1586 |
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| container_issue | 5 |
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| container_title | Journal of cellular biochemistry |
| container_volume | 104 |
| creator | Wolf, Irene M. Heitzer, Marjet D. Grubisha, Melanie DeFranco, Donald B. |
| description | A variety of coregulator proteins serve as partners for nuclear receptors orchestrating the molecular events required for receptor‐dependent transcriptional regulation. Some coregulators directly interact with nuclear receptors and provide a platform for recruitment of other factors that provide distinct biochemical activities that influence transcriptional efficiency. Coregulators can influence chromatin structure and activity via direct modification of histone proteins or by facilitating ATP‐dependent chromatin remodeling. They also have the capacity to impact multiple steps in the transcription process including initiation, elongation, and mRNA splicing. Genetic analysis in humans and animal models are revealing the important cell and tissue‐type specific actions of nuclear receptor coregulators as well and their role in human physiology and disease. J. Cell. Biochem. 104: 1580–1586, 2008. © 2008 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jcb.21755 |
| format | Article |
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Biochem. 104: 1580–1586, 2008. © 2008 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>chromatin</subject><subject>coactivator</subject><subject>Disease</subject><subject>histone</subject><subject>Humans</subject><subject>nuclear receptor</subject><subject>Receptors, Cytoplasmic and Nuclear - genetics</subject><subject>transcription</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptional Activation - genetics</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1OwzAURi0EoqUw8AKoExJDih3_xSNEUEAFpKqI0XLsWyklTYqdAH17AgkwMV3p6nxnOAgdEzwhGMfnK5tNYiI530FDgpWMmGBsFw2xpDiKKYkH6CCEFcZYKRrvowFJqKKU8yEiaWVsnb-ZuvJhbEo3LhtbgPFjDxY27Xdce1OGHsqr8hDtLU0R4Ki_I_R0fbVIb6LZ4_Q2vZhFlgrCI6VIJhzFbgmJMM4xYQ3lkiWJZMZhRaVVMQcRA8-cAmoJyxwYlgiwDDChI3TaeTe-em0g1HqdBwtFYUqomqCFanWUqBY860DrqxA8LPXG52vjt5pg_dVHt330d5-WPemlTbYG90f2QVrgvAPe8wK2_5v0XXr5o4y6RR5q-PhdGP-ihaSS6-eHqVbzlN0v5kzH9BMMoX3f</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Wolf, Irene M.</creator><creator>Heitzer, Marjet D.</creator><creator>Grubisha, Melanie</creator><creator>DeFranco, Donald B.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Coactivators and nuclear receptor transactivation</title><author>Wolf, Irene M. ; Heitzer, Marjet D. ; Grubisha, Melanie ; DeFranco, Donald B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3615-991b6d30dfe86add46ca35748874ad0937c925e62e5bd9e3c14bdea486ec4e013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>chromatin</topic><topic>coactivator</topic><topic>Disease</topic><topic>histone</topic><topic>Humans</topic><topic>nuclear receptor</topic><topic>Receptors, Cytoplasmic and Nuclear - genetics</topic><topic>transcription</topic><topic>Transcription Factors - metabolism</topic><topic>Transcriptional Activation - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolf, Irene M.</creatorcontrib><creatorcontrib>Heitzer, Marjet D.</creatorcontrib><creatorcontrib>Grubisha, Melanie</creatorcontrib><creatorcontrib>DeFranco, Donald B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolf, Irene M.</au><au>Heitzer, Marjet D.</au><au>Grubisha, Melanie</au><au>DeFranco, Donald B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coactivators and nuclear receptor transactivation</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J. 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| ispartof | Journal of cellular biochemistry, 2008-08, Vol.104 (5), p.1580-1586 |
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| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Animals chromatin coactivator Disease histone Humans nuclear receptor Receptors, Cytoplasmic and Nuclear - genetics transcription Transcription Factors - metabolism Transcriptional Activation - genetics |
| title | Coactivators and nuclear receptor transactivation |
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