SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation

In the course of screening for an inhibitor of ER stress-induced XBP1 activation, we isolated a new member of the triene-ansamycin group compound, quinotrierixin, from a culture broth of Streptomyces sp. PAE37. Quinotrierixin inhibited thapsigargin-induced XBP1 activation in HeLa cells with an IC50...

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Veröffentlicht in:	Journal of antibiotics 2008-05, Vol.61 (5), p.303-311
Hauptverfasser:	Kawamura, Tatsuro, Tashiro, Etsu, Yamamoto, Kohta, Shindo, Kazutoshi, Imoto, Masaya
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Carbon radioisotopes Chemical Phenomena Chemistry, Physical DNA-Binding Proteins - metabolism HeLa Cells Humans Luciferases - metabolism Magnetic Resonance Spectroscopy Mass Spectrometry Regulatory Factor X Transcription Factors Reverse Transcriptase Polymerase Chain Reaction Rifabutin - analogs & derivatives Rifabutin - chemistry Rifabutin - pharmacology Streptomyces - classification Streptomyces - isolation & purification Streptomyces - metabolism Stress, Physiological - metabolism Structure-Activity Relationship Tetrazolium Salts Thiazoles Transcription Factors - metabolism X-Box Binding Protein 1
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