p53 Expression and Relation to Human Papillomavirus Infection in Pingueculae, Pterygia, and Limbal Tumors

BACKGROUND The tumor suppressor gene p53 is expressed without apoptosis in the limbal basal stem cells of all pterygia and limbal tumors and most pingueculae from which these growths seem to originate. Oncogenic human papillomaviruses (HPVs) have been found in pterygia and limbal tumors, and HPV and...

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Veröffentlicht in:	Archives of ophthalmology (1960) 1999-12, Vol.117 (12), p.1593-1599
Hauptverfasser:	Dushku, Nicholas, Hatcher, Sandra L. S, Albert, Daniel M, Reid, Ted W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma in Situ - metabolism Carcinoma in Situ - pathology Carcinoma in Situ - virology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Conjunctival Diseases - metabolism Conjunctival Diseases - pathology Conjunctival Diseases - virology Corneal Diseases - metabolism Corneal Diseases - pathology Corneal Diseases - virology DNA Primers - chemistry DNA, Viral - analysis Eye Infections, Viral - metabolism Eye Infections, Viral - virology Eye Neoplasms - metabolism Eye Neoplasms - virology Genes, p53 - genetics Humans Immunoenzyme Techniques In Situ Nick-End Labeling Medical sciences Ophthalmology Papillomaviridae - genetics Papillomavirus Infections - metabolism Papillomavirus Infections - virology Polymerase Chain Reaction Pterygium - metabolism Pterygium - pathology Pterygium - virology Tumor Suppressor Protein p53 - biosynthesis Tumor Virus Infections - metabolism Tumor Virus Infections - virology Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus
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