Evaluation of replication studies, combined data analysis, and analytical methods in complex diseases

Due to genetic heterogeneity, phenocopies, incomplete penetrance, misdiagnosis, and unknown mode of inheritance, linkage studies of most complex diseases are unlikely to provide conclusive findings with unambiguously high lod scores. Typically, several marginally significant lod scores or elevated l...

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Veröffentlicht in:	Genetic epidemiology 1999, Vol.17 (S1), p.S773-S778
Hauptverfasser:	Xu, Jianfeng, Wiesch, Denise G., Taylor, Eugene W., Meyers, Deborah A.
Format:	Artikel
Sprache:	eng
Schlagworte:	complex diseases linkage Environment Genetic Linkage Genetic Markers Genetic Testing Genome Humans Models, Genetic Multifactorial Inheritance parametric and nonparametric Phenotype replication studies Reproducibility of Results Statistics, Nonparametric
Online-Zugang:	Volltext
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