The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua

At some point during biosynthesis of the antimalarial artemisinin in glandular trichomes of Artemisia annua, the Delta11(13) double bond originating in amorpha-4,11-diene is reduced. This is thought to occur in artemisinic aldehyde, but other intermediates have been suggested. In an effort to unders...

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Veröffentlicht in:	The Journal of biological chemistry 2008-08, Vol.283 (31), p.21501-21508
Hauptverfasser:	Zhang, Yansheng, Teoh, Keat H, Reed, Darwin W, Maes, Lies, Goossens, Alain, Olson, Douglas J H, Ross, Andrew R S, Covello, Patrick S
Format:	Artikel
Sprache:	eng
Schlagworte:	Artemisia annua - enzymology Artemisinins - chemistry Carbon - chemistry Cloning, Molecular Gas Chromatography-Mass Spectrometry - methods Genetic Vectors Models, Chemical Oxidoreductases - chemistry Oxidoreductases - genetics Phylogeny Plant Proteins - chemistry Plant Proteins - genetics Plant Roots - metabolism Seeds Stereoisomerism Subcellular Fractions - metabolism Time Factors
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