Staging efficacy of breast cancer with sentinel lymphadenectomy
Seventy-two patients underwent dye-guided or dye- and gamma probe-guided sentinel lymphadenectomy (SLND) followed by complete axillary lymph node dissection (ALND). The results of imprint cytology, frozen sections, and permanent sections of the sentinel lymph node (SLN) were compared to each other a...
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| Veröffentlicht in: | Breast cancer research and treatment 1999-09, Vol.57 (2), p.221-229 |
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| creator | NOGUCHI, M BANDO, E TSUGAWA, K MIWA, K YOKOYAMA, K NAKAJIMA, K.-I MICHIGISHI, T TONAMI, N MINATO, H NONOMURA, A |
| description | Seventy-two patients underwent dye-guided or dye- and gamma probe-guided sentinel lymphadenectomy (SLND) followed by complete axillary lymph node dissection (ALND). The results of imprint cytology, frozen sections, and permanent sections of the sentinel lymph node (SLN) were compared to each other and to the histologic findings in the nonsentinel nodes. The SLN was identified in 62 (88%) of 72 patients. Evaluation of the SLN on the permanent sections yielded a diagnostic accuracy of 95%, a sensitivity of 89%, and a specificity of 100%, although the reliability of SLN diagnosis using frozen sections or imprint cytology is limited. Therefore, it may be concluded that SLND with multiple sectioning and histopathologic examination of the SLNs can predict the presence or absence of axillary-node metastases in patients with breast cancer. However, further studies will be needed to investigate the value of SLND in respect to the long-term regional control and any possible detriment or benefit to survival, before it can replace routine ALND as the preferred staging operation for operable breast cancer. |
| doi_str_mv | 10.1023/A:1006268426526 |
| format | Article |
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The results of imprint cytology, frozen sections, and permanent sections of the sentinel lymph node (SLN) were compared to each other and to the histologic findings in the nonsentinel nodes. The SLN was identified in 62 (88%) of 72 patients. Evaluation of the SLN on the permanent sections yielded a diagnostic accuracy of 95%, a sensitivity of 89%, and a specificity of 100%, although the reliability of SLN diagnosis using frozen sections or imprint cytology is limited. Therefore, it may be concluded that SLND with multiple sectioning and histopathologic examination of the SLNs can predict the presence or absence of axillary-node metastases in patients with breast cancer. However, further studies will be needed to investigate the value of SLND in respect to the long-term regional control and any possible detriment or benefit to survival, before it can replace routine ALND as the preferred staging operation for operable breast cancer.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1023/A:1006268426526</identifier><identifier>PMID: 10598050</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Axilla ; Biological and medical sciences ; Biopsy, Needle - methods ; Breast cancer ; Breast Neoplasms - pathology ; Cancer research ; Cancer therapies ; Carcinoma, Ductal, Breast - pathology ; Coloring Agents ; Female ; Gynecology. Andrology. 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The results of imprint cytology, frozen sections, and permanent sections of the sentinel lymph node (SLN) were compared to each other and to the histologic findings in the nonsentinel nodes. The SLN was identified in 62 (88%) of 72 patients. Evaluation of the SLN on the permanent sections yielded a diagnostic accuracy of 95%, a sensitivity of 89%, and a specificity of 100%, although the reliability of SLN diagnosis using frozen sections or imprint cytology is limited. Therefore, it may be concluded that SLND with multiple sectioning and histopathologic examination of the SLNs can predict the presence or absence of axillary-node metastases in patients with breast cancer. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymph Node Excision - methods</topic><topic>Lymphatic Metastasis</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging - methods</topic><topic>Predictive Value of Tests</topic><topic>Sensitivity and Specificity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NOGUCHI, M</creatorcontrib><creatorcontrib>BANDO, E</creatorcontrib><creatorcontrib>TSUGAWA, K</creatorcontrib><creatorcontrib>MIWA, K</creatorcontrib><creatorcontrib>YOKOYAMA, K</creatorcontrib><creatorcontrib>NAKAJIMA, K.-I</creatorcontrib><creatorcontrib>MICHIGISHI, T</creatorcontrib><creatorcontrib>TONAMI, N</creatorcontrib><creatorcontrib>MINATO, H</creatorcontrib><creatorcontrib>NONOMURA, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NOGUCHI, M</au><au>BANDO, E</au><au>TSUGAWA, K</au><au>MIWA, K</au><au>YOKOYAMA, K</au><au>NAKAJIMA, K.-I</au><au>MICHIGISHI, T</au><au>TONAMI, N</au><au>MINATO, H</au><au>NONOMURA, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Staging efficacy of breast cancer with sentinel lymphadenectomy</atitle><jtitle>Breast cancer research and treatment</jtitle><addtitle>Breast Cancer Res Treat</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>57</volume><issue>2</issue><spage>221</spage><epage>229</epage><pages>221-229</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>Seventy-two patients underwent dye-guided or dye- and gamma probe-guided sentinel lymphadenectomy (SLND) followed by complete axillary lymph node dissection (ALND). The results of imprint cytology, frozen sections, and permanent sections of the sentinel lymph node (SLN) were compared to each other and to the histologic findings in the nonsentinel nodes. The SLN was identified in 62 (88%) of 72 patients. Evaluation of the SLN on the permanent sections yielded a diagnostic accuracy of 95%, a sensitivity of 89%, and a specificity of 100%, although the reliability of SLN diagnosis using frozen sections or imprint cytology is limited. Therefore, it may be concluded that SLND with multiple sectioning and histopathologic examination of the SLNs can predict the presence or absence of axillary-node metastases in patients with breast cancer. 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| ispartof | Breast cancer research and treatment, 1999-09, Vol.57 (2), p.221-229 |
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| subjects | Adult Aged Aged, 80 and over Axilla Biological and medical sciences Biopsy, Needle - methods Breast cancer Breast Neoplasms - pathology Cancer research Cancer therapies Carcinoma, Ductal, Breast - pathology Coloring Agents Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Lymph Node Excision - methods Lymphatic Metastasis Mammary gland diseases Medical sciences Middle Aged Neoplasm Staging - methods Predictive Value of Tests Sensitivity and Specificity Tumors |
| title | Staging efficacy of breast cancer with sentinel lymphadenectomy |
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