The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer

We have previously established a model for postmenopausal, hormone-dependent breast cancer in nude mice which is responsive to both antiestrogens and aromatase inhibitors. In this model, MCF-7 human breast carcinoma cells transfected with the aromatase gene (MCF-7CA) synthesize sufficient estrogen t...

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Veröffentlicht in:	Breast cancer research and treatment 1999-09, Vol.57 (2), p.183-192
Hauptverfasser:	QING LU, YANG LIU, LONG, B. J, GRIGORYEV, D, GIMBEL, M, BRODIE, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anastrozole Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aromatase - genetics Aromatase Inhibitors Biological and medical sciences Breast cancer Cancer research Cancer therapies Chemotherapy Disease Models, Animal Drug Screening Assays, Antitumor Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Estradiol - administration & dosage Estradiol - analogs & derivatives Estradiol - pharmacology Estrogen Antagonists - administration & dosage Estrogen Antagonists - pharmacology Female Fulvestrant Humans Letrozole Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - enzymology Mammary Neoplasms, Experimental - pathology Medical sciences Mice Mice, Inbred BALB C Mice, Nude Nitriles - administration & dosage Nitriles - pharmacology Pharmacology. Drug treatments Tamoxifen - administration & dosage Tamoxifen - pharmacology Time Factors Triazoles - administration & dosage Triazoles - pharmacology Tumor Cells, Cultured
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