Mineralocorticoid Receptor Antagonism Attenuates Cardiac Hypertrophy and Prevents Oxidative Stress in Uremic Rats

Chronic renal failure causes left ventricular hypertrophy, but the molecular mechanisms involved remain unknown. We, therefore, investigated whether the mineralocorticoid receptor is implicated in the cardiac hypertrophy observed in uremic rats and whether mineralocorticoid receptor blockade could b...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2008-08, Vol.52 (2), p.295-300
Hauptverfasser:	Michea, Luis, Villagrán, Andrea, Urzúa, Alvaro, Kuntsmann, Sonia, Venegas, Patricio, Carrasco, Loreto, Gonzalez, Magdalena, Marusic, Elisa T
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biomarkers - analysis Blotting, Western Cardiomegaly - prevention & control Disease Models, Animal Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Male Mineralocorticoid Receptor Antagonists - pharmacology Nephrectomy Oxidative Stress - drug effects Probability Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Random Allocation Rats Rats, Sprague-Dawley Receptors, Mineralocorticoid - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Spironolactone - pharmacology Uremia - physiopathology Urinalysis
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