Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain

The SH2-B protein is an SH2-domain-containing molecule that interacts with a number of phosphorylated kinase and receptor molecules including the insulin receptor. Two isoforms of the SH2-B have been identified and have been proposed to arise through alternate splicing. Here we have identified a thi...

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Veröffentlicht in:	Mammalian genome 1999-12, Vol.10 (12), p.1160-1167
Hauptverfasser:	Nelms, Keats, O'Neill, Thomas J, Li, Shiqing, Hubbard, Stevan R, Gustafson, Thomas A, Paul, William E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing alternative splicing Alternative Splicing - genetics Amino Acid Sequence Animals Base Sequence Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism chromosome 7 Chromosome Mapping chromosomes Cloning, Molecular exons Exons - genetics genes Insulin insulin receptors introns Introns - genetics Kinases Mice Mice, Inbred C57BL Molecular Sequence Data Molecular Weight obesity Phosphorylation Phosphotyrosine - genetics Phosphotyrosine - metabolism Protein Binding Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Receptor, Insulin - chemistry Receptor, Insulin - genetics Receptor, Insulin - metabolism RNA, Messenger - analysis RNA, Messenger - genetics SH2-B gene src Homology Domains - genetics Two-Hybrid System Techniques tyrosine
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